Slow-release medicine intercalation magnetic hydrotalcite with fluorescence radiation performance and preparation method thereof

A technology of magnetic hydrotalcite and luminescent properties, which is applied in the direction of non-active ingredients in medical preparations, pharmaceutical formulas, antibacterial drugs, etc.

Inactive Publication Date: 2009-04-29
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report of slow-release drug-intercalate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Take 0.01mol FeSO 4 ·7H 2 O and 0.01mol Fe 2 (SO 4 ) 3 ·xH 2 O was dissolved in de-carbonated deionized water to prepare a 100 mL solution, which was added to a 500 mL three-necked bottle, and stirred rapidly in a constant temperature water bath at 45°C. Add ammonia water dropwise to adjust the pH value to 11-12. After rapid stirring and aging for 30 minutes, the obtained black precipitate was separated by magnetic separation technology, washed repeatedly until neutral, and stored in a suspended state for later use.

[0018] (2) At room temperature, by molar ratio n(Fe 2+ ) / n(Zn 2+ ) is 0.05 Weigh the magnetic matrix in a 500mL three-necked bottle. Weigh 0.006mol Zn(NO 3 ) 2 ·6H 2 O, 0.00291mol Al(NO 3 ) 3 9H 2 O, 0.00009Eu (NO 3 ) 3 Prepare 100mL of nitrate aqueous solution. Take another certain amount of NaOH and Na 2 CO 3 Prepared into 100mL lye, where n(OH - ) / [n(Zn 2+ )+n(Al 3+ +Eu 3+ )]=2.2, n(CO 3 2- ) / [n(Zn 2+ )+n(Al 3+ +Eu 3+ )]=...

Embodiment 2

[0023] (1) Take 0.01mol FeSO 4 ·7H 2 O and 0.01mol Fe 2 (SO 4 ) 3 ·xH 2 O was dissolved in de-carbonated deionized water to prepare a 100 mL solution, which was added to a 500 mL three-necked bottle, and stirred rapidly in a constant temperature water bath at 45°C. Add ammonia water dropwise to adjust the pH value to 11-12. After rapid stirring and aging for 30 minutes, the obtained black precipitate was separated by magnetic separation technology, washed repeatedly until neutral, and stored in a suspended state for later use.

[0024] (2) At room temperature, by molar ratio n(Fe 2+ ) / n(Zn 2+ ) is 0.1 Weigh the magnetic matrix in a 500mL three-necked bottle. Weigh 0.006mol Zn(NO 3 ) 2 ·6H 2 O, 0.00291mol Al(NO 3 ) 3 9H 2 O, 0.00009Eu (NO 3 ) 3 Prepare 100mL of nitrate aqueous solution. Take another certain amount of NaOH and Na 2 CO 3 Prepared into 100mL lye, where n(OH - ) / [n(Zn 2+ )+n(Al 3+ +Eu 3+ )]=2.2, n(CO 3 2- ) / [n(Zn 2+ )+n(Al 3+ +Eu 3+ )]=0...

Embodiment 3

[0029] Change Zn(NO 3 ) 2 ·6H 2 O, Al(NO 3 ) 3 9H 2 O, Eu(NO 3 ) 3 Molar ratio, other experimental conditions are the same as in Example 1, and drug-intercalated magnetic hydrotalcites with different Zn / Al / Eu molar ratios can be prepared.

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Abstract

The invention provides a sustained-release drug intercalation magnetic houghite which has the fluorescence lighting performance, and a preparation method. A salt liquid is prepared by the mixture of a magnetic stroma, bivalent metal salt and trivalent metal salt; a lye prepared by NaOH and Na2CO3 is prepared into CO3-LDH/Fe3O4; the dried CO3-LDH/Fe3O4 is baked for 2h at the temperature of 450 DEG C to form a double-metal oxide; under the protection of N2, the double-metal oxide obtained by baking is put in a container filled with an amoxicillin sodium lye; finally the mixture is put into a constant temperature oscillator to be oscillated for 24h at the speed of 180r/min, then filtered, washed and dried to obtain the sustained-release drug intercalation magnetic houghite which has the fluorescence lighting performance and has a chemical formula: [M(II)<1-x>M(III)(1-Beta)xM'(III)Betax(OH)2]<x+>(AMX<->)a(A<n->)b question mark mH2O/Fe3O4. The invention has the advantages of removing the inorganic anions of the metal salt which completes the intercalation with the organic anions and being suitable for being inserted with a medical molecule with larger size.

Description

(1) Technical field [0001] The invention relates to a slow-release drug-intercalated magnetic hydrotalcite with fluorescent properties, and also relates to a preparation method of the slow-release drug-intercalated magnetic hydrotalcite with luminescent properties. (2) Background technology [0002] Hydrotalcite is also known as double metal hydroxides (Layered Double Hydroxides, abbreviated as LDHs). Due to its unique anion exchange function, it has nanoscale intercalation voids in its structure, and it is also the only positively charged layered host material that can undergo intercalation reactions. By introducing new guest anions into the interlayer, the composition, structure and properties of the material are changed accordingly. As a delivery carrier for drugs, LDHs have good safety, stability, biocompatibility and biodegradability. Intercalation assembled drug-LDHs materials can enhance the diffusion performance and thermal stability of drug molecules and control th...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K47/04A61K31/43A61P31/04A61K47/69
Inventor 王君刘琦仲崇娜李占双刘岩峰杨飘萍景晓燕张密林
Owner HARBIN ENG UNIV
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