Slow-release medicine intercalation magnetic hydrotalcite with fluorescence radiation performance and preparation method thereof

Abstract

The invention provides a sustained-release drug intercalation magnetic houghite which has the fluorescence lighting performance, and a preparation method. A salt liquid is prepared by the mixture of a magnetic stroma, bivalent metal salt and trivalent metal salt; a lye prepared by NaOH and Na2CO3 is prepared into CO3-LDH / Fe3O4; the dried CO3-LDH / Fe3O4 is baked for 2h at the temperature of 450 DEG C to form a double-metal oxide; under the protection of N2, the double-metal oxide obtained by baking is put in a container filled with an amoxicillin sodium lye; finally the mixture is put into a constant temperature oscillator to be oscillated for 24h at the speed of 180r / min, then filtered, washed and dried to obtain the sustained-release drug intercalation magnetic houghite which has the fluorescence lighting performance and has a chemical formula: [M(II)<1-x>M(III)(1-Beta)xM'(III)Betax(OH)2]<x+>(AMX<->)a(A<n->)b question mark mH2O / Fe3O4. The invention has the advantages of removing the inorganic anions of the metal salt which completes the intercalation with the organic anions and being suitable for being inserted with a medical molecule with larger size.

Description

(1) Technical field

[0001] The invention relates to a slow-release drug-intercalated magnetic hydrotalcite with fluorescent properties, and also relates to a preparation method of the slow-release drug-intercalated magnetic hydrotalcite with luminescent properties. (2) Background technology

[0002] Hydrotalcite is also known as double metal hydroxides (Layered Double Hydroxides, abbreviated as LDHs). Due to its unique anion exchange function, it has nanoscale intercalation voids in its structure, and it is also the only positively charged layered host material that can undergo intercalation reactions. By introducing new guest anions into the interlayer, the composition, structure and properties of the material are changed accordingly. As a delivery carrier for drugs, LDHs have good safety, stability, biocompatibility and biodegradability. Intercalation assembled drug-LDHs materials can enhance the diffusion performance and thermal stability of drug molecules and control th...