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Medicine release measuring equipment and method for medicine eluting vascular inner rack

A technology for measuring devices and eluting stents, which is applied in the direction of testing pharmaceutical preparations, material inspection products, etc., and can solve the problems that the measuring device cannot accurately simulate in vivo conditions, and cannot measure drug deposition and distribution.

Inactive Publication Date: 2013-07-31
CHONGQING UNIV
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Problems solved by technology

[0005] The purpose of the present invention is to address the above-mentioned deficiencies, to provide a drug release measurement method and device for drug-eluting intravascular stents, to solve the problems that the existing measurement devices cannot accurately simulate the conditions in the body and cannot measure the deposition and distribution of drugs on vascular tissues

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  • Medicine release measuring equipment and method for medicine eluting vascular inner rack

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Embodiment Construction

[0020] see figure 1 , the drug release assay device of the drug-eluting intravascular stent includes a first liquid storage tank 1, a high-pressure gas cylinder 2, a first silicone tube 3, a second silicone tube 4, a peristaltic pump 5, a third silicone tube 6, a first Two liquid storage tanks 7, a first glass tube 8, a blood vessel insertion tank 10, a target blood vessel 11, a bracket 12, a bellows pressure gauge 14, a flow valve 15, and a second glass tube 16; the first liquid storage tank 1 is connected with First and second silicone tubes 3, 4, the other end of the first silicone tube 3 is connected with a high-pressure gas cylinder 2, the gas is passed into the first liquid storage tank 1, and the second silicone tube 4 is connected with a peristaltic pump 5, the peristaltic pump 5 Input the buffer solution in the first liquid storage tank 1 to the upper second liquid storage tank 7 through the third silicone tube 6, and the fourth silicone tube 17 and the first glass tu...

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Abstract

The invention relates to a drug release measuring device and a drug release measuring method which are provided for an endovescular stent. The invention solves the problem that the existing measuring device cannot simulate the condition within a human body or measure the deposition and distribution of the drug on vascular tissues. The method mainly comprises: a buffer solution is prepared; an animal vessel is separated and fixed, the stent is implanted and expanded, and a flow environment within the body is simulated; and samples are collected and tested. The measuring device comprises a reservoir, a silicone tube, a glass tube, a vessel implantation groove, a diaphragm capsule dilatometer, a flow valve, a high pressure gas cylinder and a peristaltic pump, wherein, the reservoir is connected with the vessel container by the glass tube; the vessel implantation groove is connected with the reservoir by the glass tube which contains the diaphragm capsule dilatometer and the flow valve; the reservoirs are connected together by the silicone tube which is provided with the peristaltic pump; the high pressure gas cylinder is connected with the reservoir by the silicone tube. The invention can not only simulate the flow condition within body accurately which can provide better support for the vivo experiment, but also measure the deposition and distribution of the drug on the vasculartissues.

Description

technical field [0001] The invention relates to a method for measuring drug release and a device thereof, in particular to a method for measuring drug release of a drug-eluting intravascular stent and a device thereof. Background technique [0002] With the improvement of people's living standards and the entry into an aging society, the incidence of cardiovascular and cerebrovascular diseases such as stroke and coronary heart disease caused by atherosclerosis is increasing. Stroke and coronary heart disease together constitute the number one killer of Chinese people. Although there are many types of drug treatments for such diseases, they have limited effects on the regression and stabilization of atherosclerotic plaques. Percutaneous transluminal angioplasty, developed in the 1980s, has achieved impressive results as an effective means of treating coronary heart disease. The clinical treatment effect is satisfactory, but the restenosis rate after operation is 30%-50%, whic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/15
Inventor 王贵学侯延斌罗来龙
Owner CHONGQING UNIV
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