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Calcium oxalate crystallization inhibitor and uses thereof

A technology of crystallization inhibitor and calcium oxalate, which is applied in the fields of sulfur/selenium/tellurium active ingredients, urinary system diseases, element selenium/tellurium, etc., can solve the problems of complex preparation and purification, human side effects, complex ingredients, etc., and achieve simple preparation process , the effect of a wide range of application prospects

Inactive Publication Date: 2009-05-20
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Some of the above-mentioned stone inhibitors are complicated to prepare and purify, and some have complex components that may cause certain side effects on the human body. The application of nano-selenium as a stone inhibitor has the prospect of overcoming the aforementioned shortcomings

Method used

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  • Calcium oxalate crystallization inhibitor and uses thereof
  • Calcium oxalate crystallization inhibitor and uses thereof
  • Calcium oxalate crystallization inhibitor and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Under normal temperature and pressure (15~35℃, 1 standard atmosphere), take 4×10 -4 mol·L -1 Add 25ml of Vitamin C solution to a 50ml volumetric flask, and add 2×10 dropwise -4 mol·L -1 Selenium dioxide solution to the graduation mark, and gently shake it while dripping. When the red color does not change, the obtained 1×10 -4 mol·L -1 Nano-selenium is the calcium oxalate crystallization inhibitor of the present invention.

[0031] In three 25mL volumetric flasks, add 0.375mL 0.02mol·L to each volumetric flask -1 CaCl 2 , 2.5mL 0.02mol·L -1 NaCl, 0.375mL 0.02mol·L -1 Na 2 Oxa, add twice distilled water to about 20mL, shake well and filter the solution with a 0.22μm microporous membrane, and then add an appropriate amount of 1×10 -4 mol·L -1 Nano-selenium, diluted to the mark with double distilled water, in the final solution of each volumetric flask, c(Ca 2+ )=c(Oxa 2- )=3×10 -4 mol·L -1 , C(NaCl)=0.01mol·L -1 , The concentration of nano-selenium is 0, 1×10 -7 And 1×10 -6 m...

Embodiment 2

[0034] Under normal temperature and pressure (15~35℃, 1 standard atmosphere), take 4×10 -2 mol·L -1 Add 25ml of Vitamin C solution to a 50ml volumetric flask, and add 2×10 dropwise -2 mol·L -1 Selenium dioxide solution to the graduation line, and gently shake it while dripping. When the red color does not change, the obtained 1×10 -2 mol·L -1 Nano-selenium is the calcium oxalate crystallization inhibitor of the present invention.

[0035] In two 25mL volumetric flasks, add 0.375mL 0.02mol·L to each volumetric flask -1 CaCl 2 , 2.5mL 0.02mol·L -1 NaCl, 0.375mL 0.02mol·L -1 Na 2 Oxa, add twice distilled water to about 20mL, shake well, filter the solution with 0.22μm microporous membrane, and then add appropriate amount of 1×10 -2 mol·L -1 Nano-selenium, diluted to the mark with double distilled water, in the final solution of each volumetric flask, c(Ca 2+ )=c(Oxa 2- )=3×10 -4 mol·L -1 , C(NaCl)=0.01mol·L -1 , The concentration of nano-selenium in the four volumetric flasks is 1×10...

Embodiment 3

[0038] Under normal temperature and pressure (15~35℃, 1 standard atmosphere), take 4×10 -3 mol·L -1 Add 25ml of Vitamin C solution to a 50ml volumetric flask, and add 2×10 dropwise -3 mol·L -1 Selenium dioxide solution to the graduation line, and gently shake it while dripping. When the red color does not change, the obtained 1×10 -3 mol·L -1 Nano-selenium is the calcium oxalate crystallization inhibitor of the present invention.

[0039] In four 25mL volumetric flasks, add 0.375mL 0.02mol·L to each volumetric flask -1 CaCl 2 , 2.5mL 0.02mol·L -1 NaCl, 0.375mL 0.02mol·L -1 Na 2 Oxa, add twice distilled water to about 20mL, shake well, filter the solution with 0.22μm microporous membrane, and then add appropriate amount of 1×10 -4 mol·L -1 Or 1×10 -3 mol·L -1 Nano-selenium, diluted to the mark with double distilled water, in the final solution obtained in the volumetric flask, c(Ca 2+ )=c(Oxa 2- )=3×10 -4 mol·L -1 , C(NaCl)=0.01mol·L -1 , The concentration of nano-selenium in the f...

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Abstract

The invention discloses calcium oxalate crystallization inhibitor and application thereof. The inhibitor is prepared by nano selenium which is obtained by mixed reaction of selenite solution and vitamin C solution according to certain proportion. Preferably, the selenite is sodium selenite or selenium dioxide, and the vitamin C is reduced vitamin C. The invention uses the nano selenium to prepare the calcium oxalate crystallization inhibitor for the first time; and the obtained inhibitor can effectively inhibit growth and gather of calcium oxalate, and can be used for preparing calculus inhibiting medicament of the calcium oxalate.

Description

Technical field [0001] The invention belongs to the field of preparation of stone inhibitors, and specifically relates to a calcium oxalate crystallization inhibitor and applications thereof. Background technique [0002] Nano-selenium (selenium nano-sol) is the selenium supplement with the lowest acute toxicity that has been found. In terms of biological efficacy, the efficiency of nano-selenium scavenging hydroxyl radicals in vitro is 5 times that of inorganic selenium compounds and 2.5 times that of organic selenium. Nano-selenium shows anti-tumor and immune-regulation health care effects at very low doses, while the corresponding low-dose inorganic selenium has no effect. Nano-selenium's health care effects show exceptionally sensitive characteristics. Nano-selenium has high biological activity like inorganic selenium and organic selenium. It also has other characteristics different from the two: 1. High biological activity. Using nanoparticles as the carrier of drugs or anti...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61P13/04C01B19/02C07C55/06
Inventor 白燕梁敏思郑文杰周艳晖
Owner JINAN UNIVERSITY
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