Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Complex formulation for preventing or treating osteoporosis which comprises solid dispersion of vitamin d or its derivative and bisphosphonate

A technology of solid dispersion and composite preparation, applied in the field of preparation of the composite preparation, prevention or treatment of osteoporosis

Inactive Publication Date: 2009-09-16
HANMI SCI CO LTD
View PDF2 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, these complex preparations have a problem of rapid decomposition due to the high reactivity of vitamin D

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Complex formulation for preventing or treating osteoporosis which comprises solid dispersion of vitamin d or its derivative and bisphosphonate
  • Complex formulation for preventing or treating osteoporosis which comprises solid dispersion of vitamin d or its derivative and bisphosphonate
  • Complex formulation for preventing or treating osteoporosis which comprises solid dispersion of vitamin d or its derivative and bisphosphonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] According to the amount described in Table 1, add 2-hydroxypropyl-β-cyclodextrin (Aldrich) to the ethanol / water mixture and stir until the solution becomes clear, then add it to it Cholecalciferol (Fluka, Chemie GmbH, Buchs). The resulting mixture was spray-dried with a spray dryer (Buchi, MiniSpray Dryer, B-191, Switzerland) to obtain a solid dispersion. The spray drying was performed at an inlet temperature of 50°C and a pump speed of 30 rpm, followed by drying the solid dispersion at 50°C for 2 hours after spraying.

Embodiment 2

[0070] The steps of Example 1 were repeated to prepare a solid dispersion of vitamin D or its derivatives, except that 0.02 mg of d,l-α-tocopherol (BASF) was further added.

Embodiment 3

[0072] The steps of Example 1 were repeated to prepare a solid dispersion of vitamin D or its derivatives, except that 0.05 mg of ascorbic acid (BASF) was further added.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a solid dispersion comprising vitamin D or a derivative thereof and a cyclodextrin; a complex formulation for the prevention or treatment of osteophorosis, which comprises said solid dispersion and a bisphosphonate; and a method for preparing said complex formulation. The complex formulation of the present invention comprising vitamin D or a derivative thereof and a bisphosphonate can maintain a constant therapeutic level of vitamin D or a derivative thereof through its improved drug stability, while enhancing the patient compliance by minimizing inconvenience and adverse effects when administered to patients. Therefore, the complex formulation of the present invention can be advantageously used for preventing and treating osteophorosis.

Description

Technical field [0001] The present invention relates to a solid dispersion comprising vitamin D or a derivative thereof and cyclodextrin, a composite preparation for preventing or treating osteoporosis comprising the solid dispersion and a bisphosphonate, and the preparation of the composite preparation Methods. Background technique [0002] Osteoporosis is a metabolic bone disease in which bone mineral density (BMD) is reduced and bone microstructure is destroyed, leading to an increased risk of fractures. Osteoporosis can be caused by some congenital factors, menopause, hyperthyroidism, hyperparathyroidism, chronic renal failure, or administration of glucocorticoid drugs, and it is most common in postmenopausal women with estrogen deficiency. The increase in osteoclast resorption far exceeds the bone formation of osteoblasts and reduces intestinal calcium absorption, which leads to a rapid decrease in BMD. [0003] In the treatment of osteoporosis, bisphosphonates that reduce b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/592A61K9/16
CPCA61K9/5042A61K9/1652C08B37/0015A61K9/2054A61K9/2866A61K9/205C08L5/16A61K31/592A61K9/1611B82Y5/00A61K47/48969A61K9/1629A61K47/6951A61P19/10A61P3/02A61P3/14A61K9/10A61K31/59
Inventor 禹钟守李鸿基陈周男
Owner HANMI SCI CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com