Protective agent for retinal nerve or optic nerve
一种视网膜、视神经的技术,应用在视网膜神经或视神经的保护剂领域,能够解决作用未知等问题,达到优异效果的效果
Inactive Publication Date: 2009-12-02
SANWAKAGUKU KENKYUSHO CO LTD
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However, its role as a protective agent for retinal nerves or optic nerves is completely unknown
Also, there are no reports of other aldose reductase inhibitors acting as retinal nerve or optic nerve protectors
Method used
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[0042] 1. Test method
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Abstract
To provide a protective agent for a retinal nerve or an optic nerve, which exhibits its efficacy through a mechanism that is different from that for a conventional therapeutic agent and can be ingested over a long period. [MEANS FOR SOLVING PROBLEMS] Disclosed is protective agent for a retinal nerve or an optic nerve, which comprises a compound having an inhibitory activity on an aldose reductase, such as a compound represented by the general formula below, as an active ingredient. Preferably, the compound is (2S,4S)-6- fluoro-2',5'-dioxospiro[chromane-4,4'-imidazolidine]-2- carboxamide. wherein X represents a halogen atom ora hydrogen atom; R and R independently represent a hydrogen atom or a C1-6 alkyl group which may be substituted, or R and R together with a nitrogen atom located at the base of R and R or additionally together with other nitrogen atom or an oxygen atom may form a 5- to 6-membered heterocyclic ring.
Description
technical field [0001] The present invention relates to a protective agent for retinal nerve or optic nerve, which contains a compound having an aldose reductase inhibitory effect as an active ingredient. Background technique [0002] Various retinal degenerative diseases caused by the death of retinal nerve cells are the main causes of blindness. That is, visual dysfunction such as poor vision and visual field defects is caused by degeneration and detachment of the retinal nerve or optic nerve due to persistent or acute intraocular pressure, ischemia, inflammation, and the like. Additionally, the retinal or optic nerves often do not regenerate, so regaining lost function is extremely difficult. [0003] Among them, primary open-angle glaucoma is the main cause of blindness in developed countries, and intraocular pressure lowering therapy is performed by drug administration or laser trabeculoplasty. But even if the progression of glaucoma can be delayed, it is still diffic...
Claims
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/198A61K31/407A61K31/41A61K31/4166A61K31/4184A61K31/4188A61K31/425A61K31/50A61K31/501A61K31/517A61K31/5415A61P9/00A61P25/02A61P27/02A61P27/06A61P43/00C07D491/107
CPCA61K31/50A61K31/4166A61K31/41A61K31/198A61K31/5415A61K31/425A61K31/501A61K31/4188C07D491/107A61K31/407A61K31/517A61K31/4184A61P9/00A61P25/02A61P27/00A61P27/02A61P27/06A61P43/00
Inventor 钟金淑子钟森文日比千寻
Owner SANWAKAGUKU KENKYUSHO CO LTD
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