35results about How to "Long-term administration" patented technology

The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or individuals and comparing the molecular flux rates of two or more biological molecules, including biological molecules in different chemical classes. The methods find use in several applications including diagnosing, prognosing, or monitoring a disease, disorder, or condition, the in vivo high-throughput screening of chemical entities and biological factors for therapeutic effects in various disease models, and the in vivo high-throughput screening of chemical entities and biological factors for toxic effects.

Methods and compositions are described to treat a cancer having a specific oncogenic driving mutation by administering a CDK4/6 inhibitor in combination with an additional kinase inhibitor, wherein the specific combination provides advantageous or synergistic inhibitory activity, delays acquired resistance to the additional kinase inhibitor, and/or extends the efficacy of the kinase inhibitor.

The present invention relates to a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity comprising a polypeptide comprising a bee venom-PLA2 amino acid sequence exclusive of a leader sequence as an active ingredient. The secretory bee venom-phospholipase A2 of the present invention activates a regulatory T cell and suppress a differentiation of Th1/Th7. Therefore, the present polypeptide can be used as a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity, i.e. autoimmune diseases, allergic diseases, or neurodegenerative diseases.

The invention specifically relates to a biological fertilizer capable of restoring heavy metal contaminated soil and a preparation method thereof, belonging to the technical field of agricultural fertilizers. The biological fertilizer comprises the following raw materials by weight: 10 to 50% of a seaweed organic fertilizer, 10 to 50% of illite powder and 10 to 50% of humic acid powder. According to the invention, fertilizers like a nitrogen, phosphorus or potassium fertilizer or a medium trace element fertilizer can be added into the biological fertilizer capable of restoring the heavy metal contaminated soil, and frequently used binders in the field of fertilizer may be crushed and added into the biological fertilizer so as to prepare a multifunctional granular fertilizer through conventional granulation; the biological fertilizer provided by the invention has the advantages of usage of widely-available raw materials, simple production process, low equipment investment and low cost and is a functional biological organic fertilizer with significant effect on restoring the heavy metal contaminated soil; and while the biological fertilizer is normally applied as an organic fertilizer for nutrient supply, the biological fertilizer has the functions of passivating heavy metals in soil and restoring contaminated soil, is applicable to various types of soil, has significant effects and can be applied for a long time.

The present invention discloses pharmaceutical-grade ferric organic compounds, including ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. A manufacturing and quality control process for making a pharmaceutical-grade ferric citrate that consistently complies with the established Manufacture Release Specification is also disclosed. The pharmaceutical-grade ferric organic compounds are suitable for treating disorders characterized by elevated serum phosphate levels.

The invention discloses an ixeris sonchifolia hance preparation with an anti-gout effect. Through the anti-gout effect of the ixeris sonchifolia hance preparation, the clinical indication of ixeris sonchifolia hance is increased, so that the ixeris sonchifolia hance preparation not only can be used for treating a coronary heart disease, cerebral thrombosis, angina pectoris, anti-tumor and the like, but also can be used for treating a gout disease. An ixeris sonchifolia hance extract is taken orally and by injection, has an obvious effect on a hyperuricemia model induced by sodium urate in miceand is close to an allopurinol positive control group in effect. The ixeris sonchifolia hance preparation disclosed by the invention has the benefits that the ixeris sonchifolia hance preparation isa pure traditional Chinese medicine preparation, is small in toxic and/or side effects, has a cardiovascular and cerebrovascular protection effect and is an ideal anti-gout drug.

The invention discloses a plaster for treating cervical spondylotic myelopathy and a preparation method thereof. The plaster is mainly prepared from the following raw materials in parts by weight: 9-15 parts of root of kudzu vine, 6-9 parts of pawpaw, 9-15 parts of root of red-rooted salvia, 3-9 parts of notopterygium root, 3-9 parts of zedoary, 9-12 parts of garter snake, 9-15 parts of pyrola, 6-9 parts of radix clematidis, 1-3 parts of native copper and 5-9 parts of pangolin. The plaster disclosed by the invention has the effects of activating blood to promote menstruation, and relieving pain and dredging collaterals, and has very good treatment effect for cervical spondylotic myelopathy and complication thereof.

The present invention relates to an olive oil enriched with oleanolic acid that comprises a concentration of oleanolic acid between 580 and 650 mg/kg. This functional olive has proven to be effective in the treatment and prevention of type 2 Diabetes Mellitus and pre-diabetes. Also, the invention relates to a process for the preparation of said functional olive oil enriched with oleanolic acid.

The present invention discloses pharmaceutical-grade ferric organic compounds, including ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. A manufacturing and quality control process for making a pharmaceutical-grade ferric citrate that consistently complies with the established Manufacture Release Specification is also disclosed. The pharmaceutical-grade ferric organic compounds are suitable for treating disorders characterized by elevated serum phosphate levels.

The invention discloses a plaster for treating cervical muscle type cervical spondylosis. The plaster is mainly prepared from, by weight, 10-18 parts of bombardier beetle, 1-10 parts of pawpaw, 10-17 parts of red-rooted salvia root, 5-10 parts of notopterygium root, 3-10 parts of radix curcumae longae, 9-13 parts of krait, 6-15 parts of herba pyrolae, 3-10 parts of radix clematidis, 5-10 parts of veratrum japonicum and 5-9 parts of rhizoma dioscoreae nipponicae. The plaster can activate blood to promote menstruation, relieve pain and dredge collaterals and has a good treatment effect on cervical spondylosis and complications thereof.