35results about How to "Long-term administration" patented technology

The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or individuals and comparing the molecular flux rates of two or more biological molecules, including biological molecules in different chemical classes. The methods find use in several applications including diagnosing, prognosing, or monitoring a disease, disorder, or condition, the in vivo high-throughput screening of chemical entities and biological factors for therapeutic effects in various disease models, and the in vivo high-throughput screening of chemical entities and biological factors for toxic effects.

The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or individuals and comparing the molecular flux rates of two or more biological molecules, including biological molecules in different chemical classes. The methods find use in several applications including diagnosing, prognosing, or monitoring a disease, disorder, or condition, the in vivo high-throughput screening of chemical entities and biological factors for therapeutic effects in various disease models, and the in vivo high-throughput screening of chemical entities and biological factors for toxic effects.

A method for treating patients afflicted with cancer (including hematological malignancies) or viral infections, wherein the patients are under treatment or are to be treated with at least one anticancer or antiviral agent, and in particular (deoxy)nucleotide or (deoxy)nucleoside analog drugs, includes administering at least one small molecule inhibitor / activator (including ATP competitive inhibitors, signal transduction inhibitors / activators, protein kinase inhibitors / activators, and tyrosine kinase inhibitors / activators) in combination with the (deoxy) nucleotide or (deoxy)nucleoside analog, and wherein the small molecule inhibitor / activator is administered in sufficient amount to modulate deoxynucleotide or deoxynucleoside kinase activity (and in particular deoxycytidine kinase activity) to modulate activation of the (deoxy)nucleotide or (deoxy)nucleoside analog in vivo with a subsequent therapeutically beneficial anticancer or antiviral effect. The combined treatments together include a therapeutically effective amount.

Percutaneous absorption preparations for treating dementia which contain an adhesive composition, characterized in that the adhesive composition contains the active ingredient in a dispersed state, the active ingredient is released at a pharmacologically effective rate and the skin permeation rate thereof is at least 1.2 mug / cm<2> / h. Thus, it is possible to provide percutaneous absorption preparations whereby the therapeutic effect can be sustained over a prolonged period of time without elevating the concentration of the active ingredient in the plasma to such a level as causing the expression of side effects in the administration of remedies for dementia.

The present invention provides a blood flow promoting agent containing citrulline or a salt thereof and capsaicin or capsaicinoids as active ingredients, which is safe even by long-term administration, a food with health claims and a functional food affording such action, particularly, a blood flow promoting agent exhibiting an effective vasodilatory action of capsaicin at a low dose free of irritant property, which can be applied to improvement of athletic performance exhibited in relation to peripheral vasodilatation, suppression of fat accumulation, improvement of skin quality, as well as securing blood circulation in ischemic disease and the like, relaxation of blood vessel biased to coarctation due to advancing age, lifestyle-related diseases and the like, prophylaxis of arteriosclerosis, and prophylaxis of stiff neck, feeling of cold, erectile dysfunction, thrombosis and the like due to blood flow disorder.

The problem to be solved by the present invention is to provide a safe and efficacious therapeutic agent for dermatitis which is not only safe and efficacious for patients with dermatitis, in particular atopic dermatitis, but also significantly effective for severe cases that are judged to be intractable by conventional external preparations, and which is also safely applicable to affected areas such as the face and neck, as well as to subjects with sensitive skin, such as infants and females. Furthermore, the invention aims to provide an external preparation that is efficacious as skin care cosmetics having effects to improve elasticity and wrinkles of the skin, moisturizing effects, and hair-growth effects.The means for solving the problem is a skin external-preparation composition, in particular, a therapeutic agent for dermatitis or a skin texture-improving agent, having C-type natriuretic peptide (CNP) or B-type natriuretic peptide (BNP) as the active ingredient.

Methods and compositions are described to treat a cancer having a specific oncogenic driving mutation by administering a CDK4 / 6 inhibitor in combination with an additional kinase inhibitor, wherein the specific combination provides advantageous or synergistic inhibitory activity, delays acquired resistance to the additional kinase inhibitor, and / or extends the efficacy of the kinase inhibitor.

The present invention relates to a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity comprising a polypeptide comprising a bee venom-PLA2 amino acid sequence exclusive of a leader sequence as an active ingredient. The secretory bee venom-phospholipase A2 of the present invention activates a regulatory T cell and suppress a differentiation of Th1 / Th7. Therefore, the present polypeptide can be used as a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity, i.e. autoimmune diseases, allergic diseases, or neurodegenerative diseases.

The invention specifically relates to a biological fertilizer capable of restoring heavy metal contaminated soil and a preparation method thereof, belonging to the technical field of agricultural fertilizers. The biological fertilizer comprises the following raw materials by weight: 10 to 50% of a seaweed organic fertilizer, 10 to 50% of illite powder and 10 to 50% of humic acid powder. According to the invention, fertilizers like a nitrogen, phosphorus or potassium fertilizer or a medium trace element fertilizer can be added into the biological fertilizer capable of restoring the heavy metal contaminated soil, and frequently used binders in the field of fertilizer may be crushed and added into the biological fertilizer so as to prepare a multifunctional granular fertilizer through conventional granulation; the biological fertilizer provided by the invention has the advantages of usage of widely-available raw materials, simple production process, low equipment investment and low cost and is a functional biological organic fertilizer with significant effect on restoring the heavy metal contaminated soil; and while the biological fertilizer is normally applied as an organic fertilizer for nutrient supply, the biological fertilizer has the functions of passivating heavy metals in soil and restoring contaminated soil, is applicable to various types of soil, has significant effects and can be applied for a long time.

The invention provides an anti-caking fast-dissolving nitro-compound fertilizer and a preparation method thereof. The preparation method comprises the following steps: dispersing micronized cellulose ether, soluble sugar and a dispersant in molten urea to form anhydrous slurry; and coating the surface of nitro-compound fertilizer fine-particles with the slurry. The coating layer has anti-caking and fast-dissolving properties. Thus, the anti-caking fast-dissolving nitro-compound fertilizer is obtained.

The present invention discloses pharmaceutical-grade ferric organic compounds, including ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. A manufacturing and quality control process for making a pharmaceutical-grade ferric citrate that consistently complies with the established Manufacture Release Specification is also disclosed. The pharmaceutical-grade ferric organic compounds are suitable for treating disorders characterized by elevated serum phosphate levels.

The invention discloses an ixeris sonchifolia hance preparation with an anti-gout effect. Through the anti-gout effect of the ixeris sonchifolia hance preparation, the clinical indication of ixeris sonchifolia hance is increased, so that the ixeris sonchifolia hance preparation not only can be used for treating a coronary heart disease, cerebral thrombosis, angina pectoris, anti-tumor and the like, but also can be used for treating a gout disease. An ixeris sonchifolia hance extract is taken orally and by injection, has an obvious effect on a hyperuricemia model induced by sodium urate in miceand is close to an allopurinol positive control group in effect. The ixeris sonchifolia hance preparation disclosed by the invention has the benefits that the ixeris sonchifolia hance preparation isa pure traditional Chinese medicine preparation, is small in toxic and / or side effects, has a cardiovascular and cerebrovascular protection effect and is an ideal anti-gout drug.

The invention discloses a plaster for treating cervical spondylotic myelopathy and a preparation method thereof. The plaster is mainly prepared from the following raw materials in parts by weight: 9-15 parts of root of kudzu vine, 6-9 parts of pawpaw, 9-15 parts of root of red-rooted salvia, 3-9 parts of notopterygium root, 3-9 parts of zedoary, 9-12 parts of garter snake, 9-15 parts of pyrola, 6-9 parts of radix clematidis, 1-3 parts of native copper and 5-9 parts of pangolin. The plaster disclosed by the invention has the effects of activating blood to promote menstruation, and relieving pain and dredging collaterals, and has very good treatment effect for cervical spondylotic myelopathy and complication thereof.

The present invention provides a blood flow promoting agent containing citrulline or a salt thereof and capsaicin or capsaicinoids as active ingredients, which is safe even by long-term administration, a food with health claims and a functional food affording such action, particularly, a blood flow promoting agent exhibiting an effective vasodilatory action of capsaicin at a low dose free of irritant property, which can be applied to improvement of athletic performance exhibited in relation to peripheral vasodilatation, suppression of fat accumulation, improvement of skin quality, as well as securing blood circulation in ischemic disease and the like, relaxation of blood vessel biased to coarctation due to advancing age, lifestyle-related diseases and the like, prophylaxis of arteriosclerosis, and prophylaxis of stiff neck, feeling of cold, erectile dysfunction, thrombosis and the like due to blood flow disorder.

The invention discloses a traditional Chinese medicine plaster for treating cervical muscle type cervical spondylosis. The traditional Chinese medicine plaster is prepared from, by weight, 10-18 parts of night worms, 1-10 parts of fructus chaenomelis, 10-17 parts of radix salviae miltiorrhizae, 5-10 parts of rhizoma seu radix notopterygii, 3-10 parts of rhizoma curcumae longae, 9-13 parts of bungarus fasciatus, 6-15 parts of herba pyrolae, 3-10 parts of radix clematidis, 5-10 parts of rhizomes and roots of veratrum japonicum (Baker) Loes. and 5-9 parts of rhizoma dioscoreae nipponicae. The traditional Chinese medicine plaster has the effects of activating the blood to promote menstruation, stopping pain and dredging collaterals and has a good treating effect on cervical spondylosis and complications thereof.

The invention discloses a plaster for treating cervical muscle type cervical spondylosis and a preparation method of the plaster. The plaster disclosed by the invention is mainly prepared from the following raw materials in parts by weight: 10-18 parts of bombardier beetle, 1-10 parts of pawpaw, 10-17 parts of the root of red-rooted salvia, 5-10 parts of notopterygium root, 3-10 parts of turmeric, 9-13 parts of krait, 6-15 parts of pyrola, 3-10 parts of radix clematidis, 5-10 parts of black false hellebore, and 5-9 parts of Japanese yam. The plaster disclosed by the invention has the effects of activating blood to promote menstruation, relieving pain and dredging collaterals and has good curative effect on cervical spondylosis and complications of cervical spondylosis.

The invention discloses equipment and a process for preparing a soil conditioner from fly ash. The equipment comprises a first conveyor, a first crusher, a first closed conveyor, a first closed screening machine, a first returned material conveyor, a second closed conveyor, a fly ash bin, a high-pressure roller press, a scattering and granulating machine, a screening machine, a returned material conveyor, a quantitative packaging machine, a finished product warehouse, a second feeder, a humic acid bin, a fourth closed conveyor, a second returned material conveyor, a second closed screening machine, a fifth closed conveyor, a second crusher, a second conveyor and an automatic control device. According to the equipment and the process for preparing the soil conditioner from the fly ash, the prepared fly ash soil conditioner can be applied for a long time, the soil hardening problem is solved, trace elements necessary for crops can be supplemented, and the fly ash soil conditioner prepared by the equipment and the process for preparing the soil conditioner from the fly ash not only reduces environmental pollution, but also can create higher economic benefits.

The invention discloses a degradable orthopedics drug carrier system with osteo inductivity and a preparation method thereof. The drug carrier system essentially consists of the carrier material which is biological activity glass setting solid and the carried therapeutic drug. And the carrier material is the solid body carrier material with certain strength which is obtained through the fast curing after the reaction of highly reactive boron-containing biological activity glass and cured buffer liquid after the reaction. The carrier material can carry various drugs without thermal stability restriction, such as antibiotics, bone growth factors, antituberculosis drugs, antineoplastic drugs, which are used for the treatment of orthopedics diseases, thus composing the integrated drug carriersystem. The drug carrier system can degrade automatically under the function of human tissue fluid in a human body with a porous structure left during the degradation which provides diffusion channels for the sustainable releasing of the drugs, thus achieving the effect that the drugs are chronically and uniformly released. The drug carrier system has good biocompatibility, biological activity and osteo inductivity and can be applied to the treatment of various diseases of orthopedics.

The present invention relates to an olive oil enriched with oleanolic acid that comprises a concentration of oleanolic acid between 580 and 650 mg / kg. This functional olive has proven to be effective in the treatment and prevention of type 2 Diabetes Mellitus and pre-diabetes. Also, the invention relates to a process for the preparation of said functional olive oil enriched with oleanolic acid.

The present invention relates to a medicament for treating occlusive and / or ischemic vascular disorder comprising a carbostyril derivative and carnitine.

The purpose of the present invention is to provide a dosing technique for rifampicin, the technique being capable of long-term administration by enhancing the direct transfer of rifampicin to the brain and by suppressing the first pass to the liver. This pharmaceutical composition for nasal administration, which contains, as an active ingredient, rifampicins selected from the group consisting of rifampicin, derivatives thereof, and salts thereof, and is used for the prevention or treatment of dementia, is capable of long-term administration by enhancing the direct transfer of rifampicin to thebrain and suppressing the first pass to the liver.

The present invention discloses pharmaceutical-grade ferric organic compounds, including ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. A manufacturing and quality control process for making a pharmaceutical-grade ferric citrate that consistently complies with the established Manufacture Release Specification is also disclosed. The pharmaceutical-grade ferric organic compounds are suitable for treating disorders characterized by elevated serum phosphate levels.

The present invention aims to provide antidementia agents which are free from the problem of side effects and are excellent in safety. The present invention also aims to provide agents for improving learning and memory which are useful for improvement of learning and memory and can be ingested continuously. The present invention provides antidementia agents and agents for improving learning and memory, each comprising a cyclic dipeptide with the 2,5-diketopiperazine structure as an active ingredient.

The invention discloses a preparation method of a plaster for treating cervical muscle type cervical spondylosis. The plaster is mainly prepared from, by weight, 10-18 parts of, 1-10 parts of papayas, 10-17 parts of salvia miltiorrhiza, 5-10 parts of notopterygium roots, 3-10 parts of turmeric, 9-13 parts of kraits, 6-15 parts of a Chinese pyrola herb, 3-10 parts of clematis roots, 5-10 parts of veratrum japonicum stems or roots and 5-9 parts of dioscoreae nipponicae rhizoma. The plaster has the effects of invigorating blood circulation for relieving dysmenorrhea, relieving pain and dredging collaterals and has a very good treatment effect on cervical vertebra diseases and their complications.

The invention discloses a plaster for treating cervical muscle type cervical spondylosis. The plaster is mainly prepared from, by weight, 10-18 parts of bombardier beetle, 1-10 parts of pawpaw, 10-17 parts of red-rooted salvia root, 5-10 parts of notopterygium root, 3-10 parts of radix curcumae longae, 9-13 parts of krait, 6-15 parts of herba pyrolae, 3-10 parts of radix clematidis, 5-10 parts of veratrum japonicum and 5-9 parts of rhizoma dioscoreae nipponicae. The plaster can activate blood to promote menstruation, relieve pain and dredge collaterals and has a good treatment effect on cervical spondylosis and complications thereof.