Novel orthopaedics medicaments carrier system and preparation thereof

A carrier system and drug technology, applied in the direction of drug delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of slow degradation, incomplete degradation, no osteoconductivity and osteoinductivity, and achieve high reactivity and good biological phase. Capacitive, good biodegradable properties
CN101259277BActive Publication Date: 2012-07-25深圳市中科海世御生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
深圳市中科海世御生物科技有限公司
Publication Date
2012-07-25

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Abstract

The invention discloses a degradable orthopedics drug carrier system with osteo inductivity and a preparation method thereof. The drug carrier system essentially consists of the carrier material which is biological activity glass setting solid and the carried therapeutic drug. And the carrier material is the solid body carrier material with certain strength which is obtained through the fast curing after the reaction of highly reactive boron-containing biological activity glass and cured buffer liquid after the reaction. The carrier material can carry various drugs without thermal stability restriction, such as antibiotics, bone growth factors, antituberculosis drugs, antineoplastic drugs, which are used for the treatment of orthopedics diseases, thus composing the integrated drug carriersystem. The drug carrier system can degrade automatically under the function of human tissue fluid in a human body with a porous structure left during the degradation which provides diffusion channels for the sustainable releasing of the drugs, thus achieving the effect that the drugs are chronically and uniformly released. The drug carrier system has good biocompatibility, biological activity and osteo inductivity and can be applied to the treatment of various diseases of orthopedics.
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Description

technical field

[0001] The invention belongs to the field of biomaterials, and relates to an osteoinductive and fully degradable orthopedic drug carrier system and a preparation method thereof. Background technique

[0002] The implantable drug sustained-release system is to load the drug into a certain carrier, and then directly implant the drug carrier into the infected area. Through the special structure of the carrier (usually there are two structural forms: integral type and reservoir type), continuous and uniform A method of releasing a drug over a long period of time to kill a target bacterium. This method can avoid the shortcomings of multiple administrations and large fluctuations in drug release rate, so that the drug can reach and maintain a high concentration at the target site, while the non-drug receiving site maintains a low systemic blood drug concentration, thus eliminating the traditional method. During the treatment, the systemic drug causes the disadvant...

Claims

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