Self-microemulsion nanometer composition of ganodenic acid extract and preparation method thereof

Abstract

The invention relates to a preparation method of a self-microemulsion nanometer composition of ganodenic acid extract; the self-microemulsion nanometer composition takes ganodenic acid extract as crude drug, and the mixture of surface active agent, cosurfactant, and oil phase is adopted as drug carrier; the preparation method is characterized in that: the components are as follows by weight part:10 parts of ganodenic acid extracts, 50-400 parts of surface active agents, 100-800 parts of cosurfactants, and 15 to 600 parts of oil phase; the ganodenic acid extract is total triterpenoids in ganoderma lucidum which is obtained by extracting lucid ganoderma fruiting body with a supercritical CO2 extracting method. In the method, the total triterpenoids in ganoderma lucidum, which is an insolubility drug, is prepared into self-microemulsion formulation, so as to improve the dissolution rate of the drug, promote the drug adsorption and be beneficial to improving the bio-availability; in addition, the drug can keep a dissolution state in intestine so as to better to permeate through cell membranes dispersedly, thereby improving the drug effect of the drug and enhancing the in-vivo anti-tumor effect.

Description

technical field [0001] The present invention relates to a self-microemulsifying nano-composition of ganoderma lucidum triterpene extract, the nano-composition prepares the water-insoluble drug ganoderma total triterpene extract into a self-micro-emulsifying preparation, and the present invention also relates to this self-micro-emulsifying nano-composition method of preparation. Background technique [0002] Ganoderma lucidum is a polyporaceae fungus with a medicinal history of thousands of years, which was recorded in the earliest Chinese herbal monograph "Shen Nong Ben Cao Jing". For more than two thousand years, people have been using Ganoderma lucidum to prevent and treat tumors; modern scientific research also shows that Ganoderma lucidum has a strong anti-tumor effect. [0003] Ganoderma lucidum triterpenoids are recognized as one of the anti-tumor active ingredients of Ganoderma lucidum. However, its water solubility is very poor, which affects its oral absorption an...

AI Technical Summary

Problems solved by technology

Due to the complex composition of traditional Chinese medicine components, even the same type of components contain multiple chemical components, so it is difficult to study the effective components of traditional Chinese medicine from microemulsion

Therefore, there is no research report on the self-microemulsion preparation of triterpenoid components of Ganoderma lucidum

Images