Lamiophlomis rotata extract, medicine composition containing same and quality control method
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An extract, a unique technology, applied in the field of medicine, can solve the problem of reporting of index components without quality control, and achieve the effect of clear efficacy, stable efficacy and strong controllability
Inactive Publication Date: 2009-12-30
HENGKANG MEDICAL GROUP CO LTD
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8-o-acetyl shanzhiside methyl ester is 4 iridoid glycosides separated from the n-butanol extract of the root of the unique herb (see: Yi Jinhai et al. Research, Acta Pharmaceutica Sinica, 1997, 32(5): 357-360), at present, there is no report that the two compounds are simultaneously used as index components for quality control
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Embodiment 1
[0018] The preparation of embodiment 1 pharmaceutical material extract of the present invention
[0019] Take 1000g of unique herb, crush it, add water and decoct 3 times, the first time is 2 hours, the second and third times are 1 hour respectively, and the amount of water added each time is 8 times, the decoction is combined, filtered, and the filtrate is concentrated to relative density 1.30 (85 ℃) clear paste, dry below 80 ℃, pulverize, and the paste rate is 15-25%.
Embodiment 2
[0020] The preparation of embodiment 2 pharmaceutical material extracts of the present invention
[0021] Take 1000g of unique medicinal material, crush it, add 20 times of water and soak for 24 hours, the water temperature is 85°C, filter, the filtrate is concentrated into a clear paste with a relative density of 1.30 (85°C), dried, crushed, and the paste yield is 12-18%
Embodiment 3
[0022] The preparation of embodiment 3 pharmaceutical material extracts of the present invention
[0023] Take 1000g of unique medicinal material, grind it, add water and pressurize extraction in a pressure extraction tank for 3 times, the first time is 2 hours, the second and third time are 1 hour respectively, the amount of water added each time is 8 times, the temperature is 120 ° C, combined The extract is filtered, concentrated, dried and pulverized to obtain a paste rate of 18-25%.
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Abstract
The invention provides a lamiophlomis rotata extract comprising gardenia glucoside methyl ester and 8-O-acetyl gardenia glucoside methyl ester, and the total weight of the lamiophlomis rotata extract is not lower than 5mg / g. The invention also provides a method for detecting the quality of a lamiophlomis rotata medicinal material and the extract thereof or a medicine composition containing the lamiophlomis rotata extract, which uses the gardenia glucoside methyl ester and the 8-O-acetyl gardenia glucoside methyl ester as index components to carry out quality detection. The extract of the invention has stable medicine effect and strong controllability. By using the gardenia glucoside methyl ester and the 8-O-acetyl gardenia glucoside methyl ester as the index components to control the quality of the extract, the medicine effect is definite, the controllability is strong, the quality control method of the invention is accurate, reliable, stable and controllable, and the quality of the lamiophlomis rotata medicine can be effectively monitored by using the method to measure the content of the gardenia glucoside methyl ester in the lamiophlomis rotata medicinal material or a preparation.
Description
technical field [0001] The present invention relates to a unique herb extract, a pharmaceutical composition containing the extract and a quality control method, which belong to the field of medicine. Background technique [0002] Duyiwei is a traditional Tibetan medicinal material. It is the root, rhizome and whole plant of Lamio-phlomis rotata (Benth.) Kudo, a plant of the Labiatae family. It grows on plateaus or mountains above 3000m above sea level. Duyi is mildly cold in nature, bitter in taste, and slightly poisonous; effects: promoting blood circulation, promoting blood stasis, reducing swelling, and relieving pain; it is mainly used to treat tendons and bones due to bruises, lumbar contusion, and yellow water in joints. Its chemical components include: flavonoids, iridoids, phenylethanol glycosides, etc. The reported pharmacological activities include analgesic effect, hemostatic effect, anti-inflammatory effect, anti-tumor effect, and the effect on bone marrow myeloi...
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