Application and product of dendrobium stem alkaloids in preparation of medicament for treating diabetes mellitus

A technology of Dendrobium chinensis and total alkaloids, which can be used in drug combinations, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as unclear mechanism of action

Active Publication Date: 2010-02-24
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported in the literature that Dendrobium can lower blood sugar, protect and repair the structure and function of pancreatic tissue, but its mechanism of action is still unclear

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] Embodiment 1 of the present invention: the extraction of total alkaloids of Dendrobium nobile:

[0150] Take the medicinal material of Dendrobium nobile, crush it into coarse powder, add 95% ethanol to reflux and extract 3 times, recover the ethanol until it has no alcohol smell, adjust the pH to 3-4 with hydrochloric acid, filter, and adjust the pH of the filtrate to 10 with 10% ammonia water, Then extract with appropriate amount of chloroform for 6-7 times, collect the chloroform layer, recycle the chloroform, and dry to obtain the total alkaloids of Dendrobium nobile; wherein the content of total lipophilic alkaloids is 67.8%.

Embodiment 2

[0151] Embodiment 2 of the present invention: the extraction of total alkaloids of Dendrobium nobile:

[0152] Take the medicinal material of Dendrobium nobile, crush it into coarse powder, add ethanol to extract 3 times, recover the ethanol until it has no alcohol smell, adjust the pH to 3-4 with hydrochloric acid, filter, adjust the pH of the filtrate to 10 with sodium hydroxide solution, and then use an appropriate amount of Extract 5-6 times with chloroform, collect the chloroform layer, recover the chloroform, and dry to obtain the total alkaloids of Dendrobium nobile; wherein the content of lipophilic total alkaloids is 62.4%.

Embodiment 3

[0153] Embodiment 3 of the present invention: the application of total alkaloids of Dendrobium nobile:

[0154] Get 50-2000 mg of Dendrobium nobile total alkaloid extract, 0.1-0.40 mg of magnesium stearate, 4-12 mg of sodium carboxymethyl starch, and 50-100 mg of microcrystalline cellulose obtained in Example 1, and extract The product is mixed with sodium carboxymethyl starch and microcrystalline cellulose, sieved, mixed evenly, added an appropriate amount of water or ethanol to granulate, after drying, granulated, added magnesium stearate, and then pressed the granules with a punching device into Tablets, which are tablets for treating ischemic brain injury. The tablet is taken orally, 3 times a day, 1-3 tablets each time

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PUM

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Abstract

The invention discloses application of dendrobium stem alkaloids in preparation of medicament for treating diabetes mellitus and a product. The dendrobium stem alkaloids are components of lipotropismtotal alkaloids, which are extracted from dendrobium stems. Compared with the prior art, the invention further defines the pharmacologic action and the pharmacologic mechanism of the treatment of thediabetes mellitus through researching the influences of the dendrobium stem alkaloids to a mice blood sugar raising model and a high blood sugar and high blood fat chained streptozotocin induced diabetes mellitus rat model which are caused by epinephrine, and provides a pharmacology basis for the development of dendrobium stem medicinal materials.

Description

Technical field: [0001] The invention relates to the application and product of total biological alkaloids of Dendrobium nobile in the preparation of medicines for treating diabetes, and belongs to the technical field of traditional Chinese medicines. Background technique: [0002] Diabetes mellitus (DM) is a group of metabolic syndrome characterized by long-term hyperglycemia. Due to insulin deficiency and / or insulin biological action disorder, glucose metabolism disorder is accompanied by metabolism of fat, protein, water, electrolyte, etc. Obstacles, and can be complicated by chronic damage to multiple organs such as eyes, kidneys, nerves, and cardiovascular. In 1997, the American Diabetes Association (ADA) divided diabetes into four categories: type 1 diabetes, type 2 diabetes, other types of diabetes and gestational diabetes. [0003] Type 2 diabetes, accounting for more than 90% of the total number of diabetes, is one of the three non-communicable diseases with the hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P3/10A61K135/00
Inventor 石京山
Owner ZUNYI MEDICAL UNIVERSITY
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