Special multi-channel micro-flow controller used in syphilis diagnosis and using low-priced conducting material

Abstract

The invention relates to a special multi-channel micro-flow controller used in syphilis diagnosis and using low-priced conducting material, which pertains to the field of analysis and test. One of theaims of progress of relevant diagnosis and treatment technology is to quickly diagnose syphilis disease with low price. The invention provides a diagnosis device which can realize the aim. The key points thereof are as follows: the controller is internally provided with four branch pipelines which are connected with each other in parallel; four working electrodes are respectively arranged in thefour branch pipelines; the working electrode consists of a conductive electrode and a gold colloid sensitive film which is embedded with a syphilis specific antibody and attached on the conductive electrode; the gold colloid sensitive films of the four working electrodes are respectively embedded with four different syphilis specific antibody substances; the four antibody substances are respectively syphilis specific antibodies of TP0684, TP0453, TP0821 and TP0319; and the working electrodes take the shape of fibers, and the bodies of working electrodes is made of material of thermal decomposition and conductive polymer. The chip of the proposal has low cost and a plurality of channels.

Description

technical field [0001] The invention relates to a special microfluidic device for multi-channel syphilis diagnosis using inexpensive conductive materials. The special microfluidic device for multi-channel syphilis diagnosis is a special microfluidic chip for diagnosing syphilis antigens based on antigen / antibody specific reactions. It belongs to the field of analytical testing. Background technique [0002] Syphilis is a sexually transmitted disease (STD) caused by Treponema pallidum (TP). Treponema pallidum only infects humans under natural circumstances, and humans are the only source of infection for syphilis, mainly through sexual contact. It can also be transmitted vertically through the placenta, causing congenital syphilis in the fetus. A small number of people can also be infected by blood transfusion. Since the 1980s, syphilis has revived again in my country. According to statistics from the National Center for STD Control, the annual growth rate of the incidence...

AI Technical Summary

Problems solved by technology

(4) At present, microfluidic sensors are mostly based on optical detection systems. The instruments are expensive and bulky, and full integration is difficult. Moreover, the detection cost is high, which limits its promotion.

[0006] At present, in the field of microfluidic chip technology, the related technologies and methods of using multiple syphilis specific antibodies to simultaneously detect and rapidly diagnose multiple syphilis antigens have not been reported; on the other hand, most of the existing technologies in this field use expensive Gold is used as the core component of the test sensor, that is, the basic material of the working electrode. The use of this expensive metal material increases the manufacturing cost of related chips. In view of the known dangers of related infectious diseases detected by chips, related diseases There are unsafe factors in the gold recovery work in the detection microfluidic chip, which will increase the difficulty of the gold recovery work and increase the cost of the gold recovery operation, which may result in valuable economical considerations. The loss of resource gold, obviously, this technical flaw also needs to be eliminated

Images