Medicine composite for treating early liver fibrosis or early hepatocirrhosis decompensation, preparation method and application

A technology of liver fibrosis and composition, applied in the field of pharmaceutical composition for the treatment of liver fibrosis and liver cirrhosis in the early stage of decompensation

Inactive Publication Date: 2010-04-28
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature report on the preparation of preparations only from the three raw materials of rhubarb, sanleng and zedoary

Method used

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  • Medicine composite for treating early liver fibrosis or early hepatocirrhosis decompensation, preparation method and application
  • Medicine composite for treating early liver fibrosis or early hepatocirrhosis decompensation, preparation method and application
  • Medicine composite for treating early liver fibrosis or early hepatocirrhosis decompensation, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 pharmaceutical tablet preparation method of the present invention

[0025] Prescription: Rhubarb 15g Sanleng 10g Curcuma 10g

[0026] Preparation method 1: Rhubarb herb decoction pieces, use water as the extraction solvent, add water and decoct three times, the first time for 2 hours, the second time for 1 hour, and the third time for 1 hour, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.38 ~ 1.40 (50 ℃) clear ointment, set aside. Separately take the decoction pieces of Sanleng and Zezhu medicinal materials, use water as the solvent, add 8 times the amount of water, and distill with water, collect the volatile oil, filter the decoction, and concentrate the filtrate to a clear paste with a relative density of 1.38-1.40 (50°C). Combine the above clear pastes, add appropriate amount of auxiliary materials, mix well, vacuum dry, pulverize into fine powder, granulate, dissolve the volatile oil in ethanol, spray into the...

Embodiment 2

[0028] Embodiment 2 pharmaceutical capsule preparation method of the present invention

[0029] Prescription: rhubarb 50g triangular 150g curcuma 150g

[0030] Preparation method 1: Rhubarb herb decoction pieces, use water as the extraction solvent, add water and decoct three times, the first time for 2 hours, the second time for 1 hour, and the third time for 1 hour, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.38 ~ 1.40 (50 ℃) clear ointment, set aside. Separately take the decoction pieces of Sanleng and Zezhu medicinal materials, use water as the solvent, add 8 times the amount of water, and distill with water, collect the volatile oil, filter the decoction, and concentrate the filtrate to a clear paste with a relative density of 1.38-1.40 (50°C). Combine the above clear pastes, add appropriate amount of auxiliary materials, mix well, vacuum dry, pulverize into fine powder, granulate, dissolve the volatile oil in ethanol, spray in...

Embodiment 3

[0032] Embodiment 3 preparation method of pharmaceutical granule of the present invention

[0033] Prescription: Rhubarb 150g Sanleng 50g Curcuma 50g

[0034] Preparation method 1: Rhubarb herb decoction pieces, use water as the extraction solvent, add water and decoct three times, the first time for 2 hours, the second time for 1 hour, and the third time for 1 hour, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.38 ~ 1.40 (50 ℃) clear ointment, set aside. Separately take the decoction pieces of Sanleng and Zezhu medicinal materials, use water as the solvent, add 8 times the amount of water, and distill with water, collect the volatile oil, filter the decoction, and concentrate the filtrate to a clear paste with a relative density of 1.38-1.40 (50°C). Combine the above clear pastes, add appropriate amount of auxiliary materials, mix well, vacuum dry, pulverize into fine powder, granulate, dissolve the volatile oil in ethanol, spray int...

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PUM

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Abstract

The invention provides a medicine composite for treating early liver fibrosis or early hepatocirrhosis decompensation, which is a preparation prepared from the following raw material medicines proportioning by weight: 5-15 parts of rhubarb, 5-15 parts of rhizoma sparganii and 5-15 parts of curcuma zedoary. The invention also provides a preparation method and an application of the medicine composite. The bulk drugs in the medicine are used in combination, have the main functions of eradicating blood stasis and removing the stagnation of food, aim to deal with an emergency, can directly carry out treatment aiming at the cause of a disease, also can quickly improve the exigent symptom of the early hepatocirrhosis decompensation, protect the liver function, eliminate blood stasis, promote tissue regeneration and tonify the body in a discharge way, act as the functions of dissolving turbid urine, lessening the virulence of any pathogenic organism, relieving the stagnation of qi, removing the blood stasis and protecting the liver together, have a synergistic action and are used for treating various diseases of the early liver fibrosis or early hepatocirrhosis decompensation.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating liver fibrosis and liver cirrhosis decompensation early stage, belonging to the field of medicine. Background technique [0002] Chronic hepatitis caused by various reasons leads to inflammation and necrosis of liver cells. Inflammation and necrosis stimulate the abnormal proliferation of fibrous connective tissue in the liver. This pathological process is called hepatic fibrosis. And the formation of nodules develops into liver cirrhosis, causing serious consequences such as portal hypertension and liver failure. Fibrosis is a repair response of the liver to chronic injury, and is a common pathological change in chronic liver diseases, characterized by excessive deposition of collagen-based extracellular matrix (ECM) in the liver. Hepatic inflammation activates hepatic stellate cells (HSCs), leading to collagen production and deposition to form liver fibrosis, which further develops i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/16
Inventor 徐世军王曙宾
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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