The invention discloses a capsule for treating bone tuberculosis and a preparation method of the capsule, belonging to the field of traditional Chinese medicines. The capsule is prepared from the following active ingredients: rhizoma smilacis glabrae, ramulus et folium psychotriae serpentis, radix inulae pterocaulae, herba sonchi oleracei, all-grass of nippon cinquefoil, radix et rhizoma smilacisripariae, herba et radix paederiae scandentis, caulis et folium fici pumilae, herba pteridis multifidae, radix flemingiae philippinensis, licorice root, herba ajugae ciliatae, pseudobulbus seu herba pholidotae chinensis, radix iridis ensatae, rhizome of purple bergenia and flos rosae chinensis. The capsule is developed on the basis of the dialectical treatment of the traditional Chinese medicine and in combination with clinical practice, the medicinal materials are mixed, thus the efficacies of clearing away heat and removing dampness, expelling turbid urine and removing poisonous substances,easing joint movement, stimulating the circulation of the blood and causing the muscles and joints to relax, relieving swelling and stopping pain, promoting blood circulation to remove meridian obstruction, and the like are achieved, the capsule has the advantages of being rapid in taking effect, high in curate rate, free of toxic and side effects, and safe and convenient when used for treating the symptoms including low heat, tiredness, night sweating, anorexia, emaciation, arthralgia, malformation and the like which are caused by bone tuberculosis, and the capsule can be widely applied to clinical treatment of bone tuberculosis.