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Application of ergot sterone in preparation of diuresis medicine

An ergosterone and diuretic technology, applied in the field of medicine, can solve problems such as increased cholesterol saturation, arrhythmia, and unclear chemical components

Inactive Publication Date: 2009-12-09
NORTHWEST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the application of Polyporus in traditional medicine and modern medicine mainly focuses on diuresis and treatment of kidney diseases, and the chemical components that play a diuretic effect have not been clear.
In addition, currently existing diuretics include indapamide and furosemide. The disadvantage is that a large number of applications can easily cause hypokalemia and arrhythmia; thiazide diuretics (such as chlorothiazide, chlorthalidone and hydrochlorothiazide) have a A big disadvantage, they often reduce the potassium content in the body, in addition, thiazide diuretics can increase the saturation of cholesterol in the patient's bile, which may increase the risk of cholecystitis

Method used

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  • Application of ergot sterone in preparation of diuresis medicine

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Experimental program
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Embodiment Construction

[0009] 1 Experimental materials

[0010] 1.1 Experimental drug furosemide (furosemide): product of Jiangsu Linhai Pharmaceutical Co., Ltd., batch number 010730; ergosterone [ergosta-4, 6, 8 (14), 22-tetraen-3-one] is obtained from crude drugs were separated and analyzed by various spectroscopic and spectroscopic techniques ( 1 H NMR, 13 C NMR, 2D NMR, MS, UV and IR) identify the structure, then synthesize this compound by the method of organic synthesis, and the yield is 40%.

[0011] 1.2 Experimental animals Rats, weighing 200-260 g, male, were provided by the Animal Center of Xi'an Jiaotong University School of Medicine.

[0012] 1.3 Experimental equipment Rat metabolic cage, TD electronic balance, METTLER TOLEDO 1 / 100,000 analytical balance.

[0013] 2 Methods and results

[0014] 2.1 Synthesis of ergosterone

[0015] Synthetic Route 1: Dissolve 5.00g of ergosterol in acetone, then slowly add 20ml of sulfuric acid solution of chromic anhydride to the acetone solution o...

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Abstract

The invention relates to an application of ergot sterone in preparation of diuresis medicine. Polyporus umbellatus crude drug is mainly used for clearing damp and promoting diuresis and treating dysuria, edema, diarrhea, strangury with turbid urine and morbid leucorrhea. The inventor utilizes diuresis as pharmacological index and screens target area and active ingredients identical with the function of the polyporus umbellatus on the basis of chemical ingredient research on the polyporus umbellatus. Normal saline loaded water retention animal model is adopted for diuresis screening on sterides compound therein, and the ergot sterone is found to have better diuresis effect and is determined as the target area of diuresis of the polyporus umbellatus.

Description

technical field [0001] The invention relates to the application of ergosterone in the preparation of diuretic drugs, belonging to the technical field of medicine. Background technique [0002] Polyporus umbellatus (Pers.) Fries] is a Polyporaceae plant. Its dry sclerotium is called medicinal Polyporus umbellatus, which is a commonly used traditional Chinese medicine. It is distributed in the Americas and is also used medicinally. Polyporus has a medicinal history of more than 2,500 years in China. It was first recorded in "Shen Nong's Materia Medica", and it was recorded in later "Chinese Materia Medica" and "Treatise on Febrile Diseases". For the "Chinese Pharmacopoeia" included. It has diuretic, anticancer and antibacterial effects, and its main function is diuresis and dampness. Many diuretic compound preparations contain Polyporus, such as Zhuling Decoction, Zhuling Pill, Zhuling Powder, Wuling Powder, Fenxiao Decoction, Yinchen Wuling Powder, etc. These compounds hav...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P7/10
Inventor 赵英永谢人明孙文基
Owner NORTHWEST UNIV
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