Common lamiophlomis extract, medicine composition containing same and quality control method

A quality detection method and extract technology, applied in the field of medicine, can solve problems such as complex and difficult to predict chemical components, and achieve strong controllability, stable drug efficacy, and accurate and reliable quality control methods

Active Publication Date: 2013-02-06
康县独一味生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of the chemical composition in the unique flavor, it is difficult for those skilled in the art to predict whether the quality of the medicinal material or the extract of the unique flavor can be reflected by one of the ingredients.
At present, there is no relevant report on the use of shanzhiside methyl ester for quality control indicators

Method used

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  • Common lamiophlomis extract, medicine composition containing same and quality control method
  • Common lamiophlomis extract, medicine composition containing same and quality control method
  • Common lamiophlomis extract, medicine composition containing same and quality control method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 extract of the present invention

[0028] Take 1000g of unique herb, crush it, add water and decoct 3 times, the first time is 2 hours, the second and third times are 1 hour respectively, and the amount of water added each time is 8 times, the decoction is combined, filtered, and the filtrate is concentrated to relative density 1.30 (85°C) clear ointment, dried below 80°C, crushed to obtain ointment.

Embodiment 2

[0029] The preparation of embodiment 2 extracts of the present invention

[0030] Take 1000g of unique medicinal material, pulverize, add 20 times of water and soak for 24 hours, the water temperature is 85°C, filter, the filtrate is concentrated into a clear paste with a relative density of 1.30 (85°C), dried, and crushed to obtain a paste.

Embodiment 3

[0031] The preparation of embodiment 3 extracts of the present invention

[0032] Take 1000g of unique medicinal material, grind it, add water and pressurize extraction in a pressure extraction tank for 3 times, the first time is 2 hours, the second and third time are 1 hour respectively, the amount of water added each time is 8 times, the temperature is 120 ° C, combined The extract is filtered, concentrated, dried, and pulverized to obtain a paste.

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Abstract

The invention provides a common lamiophlomis extract which contains 1.5-30mg / g of shanzhiside methylester. The invention also provides a medicine composition containing the common lamiophlomis extract and a method for controlling the quality of the common lamiophlomis extract or the medicine composition containing the common lamiophlomis extract. The invention has stable medicine effect of the extract, definite medicine effect and strong controllability and controls the quality of the extract by taking the shanzhiside methylester as an index component. The quality control method is accurate, reliable, stable and controllable, is used for measuring the content of the shanzhiside methylester in a common lamiophlomis medicinal material or a preparation and can effectively monitor the quality of a common lamiophlomis medicine.

Description

technical field [0001] The present invention relates to a unique herb extract, a pharmaceutical composition containing the extract and a quality control method, which belong to the field of medicine. Background technique [0002] Duyiwei is a traditional Tibetan medicinal material. It is the root, rhizome and whole plant of Lamio-phlomis rotata (Benth.) Kudo, a plant of the Labiatae family. It grows on plateaus or mountains above 3000m above sea level. Duyi is mildly cold in nature, bitter in taste, and slightly poisonous; effects: promoting blood circulation, promoting blood stasis, reducing swelling, and relieving pain; it is mainly used to treat tendons and bones due to bruises, lumbar contusion, and yellow water in joints. Its chemical components include: flavonoids, iridoids, phenylethanol glycosides, etc. The reported pharmacological activities include analgesic effect, hemostatic effect, anti-inflammatory effect, anti-tumor effect, and the effect on bone marrow myeloi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02A61K36/53A61P19/00A61P19/02A61P29/00A61K125/00
Inventor 阙文彬廖立东张康宁杨婷卢胜明
Owner 康县独一味生物制药有限公司
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