Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Flavonoid compound and application of plant extract containing same

A technology of flavonoids and compounds, applied in flavonoids or plant extracts containing them in the field of medicine, can solve problems such as bone marrow suppression, high price of long-acting interferon, gastrointestinal symptoms, etc., and achieve small side effects and good resistance Effects of Hepatitis C Virus

Inactive Publication Date: 2012-09-05
SHANGHAI INST OF PHARMA IND CO LTD +1
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the treatment of interferon and ribavirin, adverse reactions such as bone marrow suppression, emotional depression, and gastrointestinal symptoms may occur
Moreover, long-acting interferon is expensive, and a 48-week course of treatment costs about 60,000 yuan

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Flavonoid compound and application of plant extract containing same
  • Flavonoid compound and application of plant extract containing same
  • Flavonoid compound and application of plant extract containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0043] The present invention is further illustrated below with examples, but the present invention is not limited thereto.

[0044] Apigenin, luteolin, baicalin naringenin and 6-methoxynaringenin used in the examples were purchased from Shanghai Traditional Chinese Medicine Standardization Center. HCV-E2 antibody was obtained from Scripps Research Institute, USA. The control drug α-interferon and other reagents and raw materials used are all commercially available in China.

[0045] Effect Example In Vitro Cell Test

[0046] 1. Sample preparation

[0047] The sample was dissolved in 100% DMSO to a mother solution with a concentration of 20 mg / ml, and stored at 4°C. When testing, the stock mother solution was diluted with 100% DMSO to 5 mg / ml and 2 mg / ml solutions respectively.

[0048] 2. Cell, virus and cell culture

[0049] This study used a Huh7-derived cell line and an HCV virus strain (obtained from the Institut Pasteur of Shanghai, Chinese Academy of Sciences), whic...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a class of flavonoid compound as shown in formula I or an application of a plant extract containing the same in preparing medicine against hepatitis c virus, wherein R1, R2, R4, R5 and R6 are independently H, OH or OMe; R3 is H, OH, OMe or beta-D-gluconic acid; and a single bond or a double bond is arranged between a second carbon and a third carbon. The flavonoid compoundhas better effects of resisting the hepatitis c virus and less side effects, mostly comes from the traditional Chinese medicine and is cheap, safe and effective. Formula I.

Description

technical field [0001] The invention relates to a new application of a class of flavonoid compounds or plant extracts containing them in the field of medicine. Background technique [0002] According to incomplete statistics, there are as many as 40 million hepatitis C antibody-positive patients in my country, and 80% of them will suffer from chronic hepatitis C. Hepatitis C is a liver disease that is transmitted through blood, sexual contact, mother to child and daily life contact. After HCV infection, like HBV infection, chronic hepatitis, liver cirrhosis and liver cancer are prone to occur. [0003] Currently, long-acting interferon combined with ribavirin is mainly used to treat hepatitis C patients with normal liver function, and the overall sustained virological response rate is 52%. However, during the treatment of interferon and ribavirin, adverse reactions such as bone marrow suppression, emotional depression, and gastrointestinal symptoms may occur. Moreover, lo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/352A61K36/539A61K36/536A61P31/12A61P1/16
Inventor 王曙光钟劲李波胡珏高雯庄昌龙孔德云
Owner SHANGHAI INST OF PHARMA IND CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com