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Molecular diagnostic agent and therapeutic agent of nasopharyngeal carcinoma, reagent kit and application thereof

A technology of nasopharyngeal carcinoma, diagnostic agent, applied in the field of diagnosis and/or treatment of nasopharyngeal carcinoma, able to solve the problems such as not having achieved great success

Inactive Publication Date: 2010-07-07
同昕生物技术(北京)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Treatment with non-specific factors such as interferon and acyclovir has also not had much success

Method used

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  • Molecular diagnostic agent and therapeutic agent of nasopharyngeal carcinoma, reagent kit and application thereof
  • Molecular diagnostic agent and therapeutic agent of nasopharyngeal carcinoma, reagent kit and application thereof
  • Molecular diagnostic agent and therapeutic agent of nasopharyngeal carcinoma, reagent kit and application thereof

Examples

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Embodiment Construction

[0030] EGFR as a target for nasopharyngeal carcinoma therapy

[0031] Epidermal growth factor receptor (EGFR) and its family members have an important relationship with abnormal cell growth control [Khazaie, K., Schirrmacher, V., and Lichtner, R. (1993). EGF receptor in neoplasia and metastasis . Cancer Metastasis Rev 12, 255-274.]. This family belongs to receptor tyrosine kinases and has four family members, namely EGFR, Neu, ErbB-3 and ErbB-4. The binding of EGFR to its corresponding ligand can lead to its formation of receptor dimers and autophosphorylation, which will trigger a signaling and cascade event, which in turn activates the activity of mitogen activating protein kinases (mitogen activating protein kinases, MAPK). Although members of the EGFR family are essential for normal cell growth, overexpression of members of this protein family has also been found in epithelial cancers. For example, one or more EGFR family members are overexpressed in more than 30-35% of...

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Abstract

The invention discloses a molecular diagnostic agent using epidermal growth factor receptors (EGFR) and nuclear factors kappa B (NF-kB) as an effective and specific labelled molecule for diagnosing nasopharyngeal carcinoma, and a therapeutic agent using inhibitors containing the EGFR and / or the NF-kB for treating the nasopharyngeal carcinoma. The invention also discloses a reagent kit for detecting the nasopharyngeal carcinoma, which contains reagent for determining the expressions or the activities of the EGFR or the NF-kB in an organism sample. The invention also provides a method for identifying compounds for treating the nasopharyngeal carcinoma.

Description

technical field [0001] The present invention relates to methods of molecular diagnosis and / or treatment of nasopharyngeal carcinoma, more particularly, to diagnosis via novel drug targets (epidermal growth factor receptor (EGFR) and / or nuclear factor-κB (NF-κB)) And / or methods, reagents, pharmaceutical compositions, kits and their applications for treating nasopharyngeal carcinoma. The new drug target can be used for diagnosing and / or treating nasopharyngeal carcinoma, evaluating the degree of progression of nasopharyngeal carcinoma and / or the effectiveness of treatment, and identifying compounds for treating nasopharyngeal carcinoma. Background technique [0002] Epstein-Barr virus (EBV) is a member of the human herpes virus family and can infect most people. The virus is associated with many malignancies, nasopharyngeal carcinoma being the most severe Epstein-Barr virus-associated epithelial cancer. The EBV genome is present in all NPC cases, however, the EBV-encoded pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50A61K35/00
Inventor 程根宏
Owner 同昕生物技术(北京)有限公司
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