A kind of anticancer drug and its preparation method and application

An anticancer drug and a technology for preparation steps, which are applied in the field of anticancer drugs and their preparation, can solve the problems of low curative effect, unsatisfactory curative effect, and large toxic and side effects of cancer, and achieve the effect of improving clinical curative effect.

Inactive Publication Date: 2012-02-15
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapeutic drugs have a certain effect on cancer, but they have severe side effects

Method used

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  • A kind of anticancer drug and its preparation method and application
  • A kind of anticancer drug and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: anticancer drug and preparation method thereof

[0015] (1) Prescription: 1 part of Ganoderma lucidum, 1 part of Coix Seed, 2 parts of Tiger Eye Evergreen.

[0016] (2) Preparation method: Weigh 1 part of Ganoderma lucidum, 1 part of Coix Seed, 2 parts of Evergreen, dry and crush in the shade, soak and extract with 16 times the amount of 65% ethanol solution at 70°C for 4 times, 5 hours each time, recover the ethanol and concentrate into an extract, vacuum-dried to obtain an anticancer drug.

Embodiment 2

[0017] Embodiment 2: anticancer drug and preparation method thereof

[0018] (1) Prescription: 2 parts of Ganoderma lucidum, 2 parts of Coix Seed, 6 parts of Tiger Eye Evergreen.

[0019] (2) Preparation method: Weigh 2 parts of ganoderma lucidum, 2 parts of coix seed, 6 parts of evergreen, dry and crush in the shade, soak and extract with 18 times the amount of 70% ethanol solution at 75°C for 4 times, each time for 6 hours, and recover ethanol Concentrate into an extract and dry it in a vacuum to obtain an anticancer drug.

Embodiment 3

[0020] Example 3: Inhibitory Effect of Anticancer Drugs on Transplanted Lung Cancer

[0021] 1. Experimental animals and tumor strains

[0022] Male healthy C57BL / 6 mice, weighing 18-22 g, aged 6-8 weeks, were purchased from the Animal Experiment Center of our school; mouse Lewis lung cancer tumor strains were purchased from the Animal Experiment Center of Jiangsu Cancer Institute.

[0023] 2. Modeling and experimental methods

[0024] There were 60 C57BL / 6 mice, 10 were randomly reserved in proportion as the negative control group, and the remaining 50 were used for modeling. Prepare Lewis lung cancer tumor-bearing mice, peel off the tumor tissue in the vigorous growth period, and select a well-growing tumor of 1.5mm 3 Left and right, homogenate according to the ratio of tumor (g): normal saline (ml) 1:3, adjust the number of cells to 2×10 6 / ml. Select healthy mice, and inoculate 0.2 ml subcutaneously in the right axilla of each mouse under aseptic conditions. The entir...

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Abstract

An anticancer drug and a preparation method thereof, which is prepared from a raw material drug of ganoderma lucidum, coix seed, and evergreen in a certain weight ratio, and the preparation method is to use 15-18 times the amount of 60%-70% ethanol The solution is soaked and extracted at 65°C-75°C for 3-4 times, each time for 5-6h, and the ethanol is recovered and concentrated to obtain the anticancer drug. According to the anti-cancer pharmacological experiments in animals, it has obvious inhibitory effect on the growth of lung cancer and breast cancer, and its anti-cancer activity is higher than that of chemotherapy drug 5-fluorouracil.

Description

1. Technical field [0001] The invention relates to the technical field of traditional Chinese medicine and its preparation, in particular to an anticancer drug prepared by using ganoderma lucidum, coicis seed and evergreen as raw materials and a preparation method thereof. 2. Background technology [0002] Cancer is a formidable enemy that endangers human health. There are about 1.6 million new cancer cases in my country every year, and about 1.3 million people die from cancer every year. The number of deaths due to cancer in the country is increasing year by year. my country is a high-incidence area for lung cancer, breast cancer, liver cancer and other cancers. Cancer mortality stay high. [0003] There are currently no effective drugs that cure most cancer patients. Although chemotherapeutic drugs have certain curative effects on cancer, they have severe side effects, and Chinese patent medicines generally have low curative effects on cancer, and the curative effects are...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K36/8994A61P35/00
Inventor章永红章迅
OwnerNANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE