Chinese medicinal active ingredient compound preparation for treating breast cancer and lung cancer and preparation method thereof

A technology of active ingredients and compound preparations, which is applied in the field of compound preparations of active ingredients of traditional Chinese medicine for the treatment of breast cancer and lung cancer and its preparation, which can solve the problems of unsatisfactory curative effect, low cancer curative effect, large toxic and side effects, etc.

Inactive Publication Date: 2012-07-25
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapeutic drugs have a certain effect on cancer, but they have severe side effects

Method used

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  • Chinese medicinal active ingredient compound preparation for treating breast cancer and lung cancer and preparation method thereof
  • Chinese medicinal active ingredient compound preparation for treating breast cancer and lung cancer and preparation method thereof
  • Chinese medicinal active ingredient compound preparation for treating breast cancer and lung cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: A compound preparation of active ingredients of traditional Chinese medicine, made from 1 part (10 mg) of paclitaxel, 1 part (10 mg) of cinobufaction base and 1 part (10 mg) of triptolide, wherein the preparation method of liposomes is as follows:

[0026] (1) The preparation materials and proportions of the active ingredient compound liposome of traditional Chinese medicine are as follows: the mass ratio of lecithin to mPEG2000-DSPE (amphipathic polyethylene glycol 2000-distearoylphosphatidylethanolamine) is 10:1, and The mass ratio of cholesterol is 10:1, and the mass ratio of the active ingredient compound drug of traditional Chinese medicine is 30:1;

[0027] (2) The preparation method of the compound liposome active ingredient of traditional Chinese medicine is as follows: prepare by ethanol injection method, accurately measure 90 mL of PBS buffer solution with pH 7.4 in an eggplant-shaped bottle, preheat in a constant temperature water bath at 50 ° C for...

Embodiment 2

[0031] Example 2: A compound preparation of active ingredients of traditional Chinese medicine, made of 2 parts (20 mg) of paclitaxel, 2 parts (20 mg) of cinobufaction base and 2 parts (20 mg) of triptolide, wherein the preparation method of liposome is as follows:

[0032] (1) The preparation materials and ratio of the active ingredient compound liposome of traditional Chinese medicine are: lecithin and mPEG2000-DSPE respectively

[0033] (Amphiphilic polyethylene glycol 2000-distearoyl phosphatidylethanolamine) mass ratio is 10: 1, the mass ratio to cholesterol is 10: 1, and the mass ratio to traditional Chinese medicine active ingredient compound drug is 30: 1;

[0034] (2) The preparation method of the compound liposome active ingredient of traditional Chinese medicine is as follows: prepare by ethanol injection method, accurately measure 180mL of PBS buffer solution with pH 7.4 in an eggplant-shaped bottle, preheat in a constant temperature water bath at 50°C for 30min; le...

Embodiment 3

[0038] Example 3: Compound preparation of active ingredients of traditional Chinese medicine, made of 3 parts (30 mg) of paclitaxel, 3 parts (30 mg) of cinobufaction base and 3 parts (30 mg) of triptolide, wherein the preparation method of liposome is as follows:

[0039] (1) The preparation materials and proportions of the active ingredient compound liposome of traditional Chinese medicine are as follows: the mass ratio of lecithin to mPEG2000-DSPE (amphipathic polyethylene glycol 2000-distearoylphosphatidylethanolamine) is 10: 1.2, and The mass ratio of cholesterol is 10:1.2, and the mass ratio of the active ingredient compound drug of traditional Chinese medicine is 30:0.8;

[0040] (2) The preparation method of the compound liposome of the active ingredient of traditional Chinese medicine is as follows: prepare by ethanol injection method, accurately measure 270mL of PBS buffer solution with pH 7.4 in an eggplant-shaped bottle, preheat in a constant temperature water bath a...

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Abstract

The invention discloses a Chinese medicinal active ingredient compound preparation for treating a breast cancer and a lung cancer and a preparation method thereof. The Chinese medicinal active ingredient compound preparation is a Chinese medicinal active ingredient compound prepared from taxol, cinobufagin and triptolide according to a certain weight proportion. In the preparation method, a liposome is prepared by adopting an ethanol inpouring method, or polyethylene glycol is taken as a substrate for preparing a dropping pill, so that the Chinese medicinal active ingredient compound preparation is obtained. The compound preparation is of the dosage form of a compound liposome and a compound dropping pills. As proved by an animal in-vivo anti-cancer pharmacological experiment, the Chinesemedicinal active ingredient compound preparation has remarkable restraining action on the growth of the breast cancer and the lung cancer, and the anti-cancer activity of the compound preparation is remarkably higher than that of a chemotherapeutic medicament, i.e., 5-fluorouracil.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound preparation of active ingredients of traditional Chinese medicines for treating breast cancer and lung cancer and a preparation method thereof. Background technique [0002] Cancer is a formidable enemy that endangers human health. There are about 1.6 million new cancer cases in my country every year, and about 1.3 million people die from cancer every year. The number of deaths due to cancer in the country is increasing year by year. my country is a high-incidence area for lung cancer, breast cancer, liver cancer and other cancers. Cancer mortality stay high. [0003] There are currently no effective drugs that cure most cancer patients. Although chemotherapeutic drugs have certain curative effects on cancer, they have severe side effects, and Chinese patent medicines generally have low curative effects on cancer, and the curative effects are not...

Claims

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Application Information

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IPC IPC(8): A61K31/585A61K31/337A61P35/00A61P15/14A61P11/00
Inventor章永红章迅
OwnerNANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE