Method for online detecting near infrared spectrum of active ingredients of compound eucommia bark capsules

A compound Eucommia capsule, near-infrared spectroscopy technology, applied in color/spectral property measurement, measurement device, analysis material and other directions, can solve the problems of complex sample processing process and operation, difficult to achieve online detection and so on

Inactive Publication Date: 2010-07-28
FUREN PHARMA GROUP
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Problems solved by technology

At present, the traditional determination methods such as HPLC, the sample processing process and operation are complicated, and it is difficult to realize online detection

Method used

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Embodiment Construction

[0015] The near-infrared spectroscopy online detection method of active ingredients in the production process of compound eucommia capsules, the detection steps are as follows:

[0016] 1. Determine the content of active ingredients pinoresinol diglucoside, baicalin, rhynchophylline and isorhynchophylline in the compound eucommia capsule sample with high performance liquid chromatography (HPLC), and use this content as a reference value. The specific method is as follows:

[0017] (1) Determination of content of pinoresinol diglucoside:

[0018] Chromatographic conditions and system suitability test: use octadecylsilane bonded silica gel as filler; methanol-water (25:75) as mobile phase; detection wavelength is 277nm. The number of theoretical plates should not be less than 1000 based on the peak of pinoresinol diglucoside.

[0019] Preparation of reference substance solution: Accurately weigh an appropriate amount of pinoresinol diglucoside reference substance, add methanol...

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Abstract

The invention discloses a method for online detecting the near infrared spectrum of active ingredients of compound eucommia bark capsules. The active ingredients of the compound eucommia bark capsules mainly comprise pinoresinol diglucoside, baicalin, rhynchophylline, isorhynchophylline, and the like. The method comprises the steps of collecting the near infrared absorption spectrum of the compound eucommia bark capsules, associating active ingredients content data obtained by an HPLC (High Performance Liquid Chromatography) method with the near infrared spectrum of a sample, establishing a correction model by a partial least squares cofinal method and realizing quick online detection of the active ingredients of the capsules. Research results show that the near infrared spectrum analysis method can effectively detect the active ingredients of the compound eucommia bark capsules, has simple sample, quick detection and multiple components detection at the same time, can be used for real-time analysis and online quality control during pharmaceutical processing of the traditional Chinese medicine for controlling the quality of medicines in all dimensions, enhances production automation and informatization level of traditional Chinese medicine and promotes the development of the pharmaceutical industry.

Description

technical field [0001] The invention relates to an online detection method using near-infrared spectrum in the production process of traditional Chinese medicines, in particular to a near-infrared online detection method for active ingredients in the production process of compound eucommia capsules. Background technique [0002] Compound Eucommia Capsule is a traditional Chinese medicine compound preparation extracted and refined from Eucommia ulmoides, Motherwort, Prunella vulgaris, Uncaria, and Scutellaria baicalensis. At the same time of stable and continuous blood pressure reduction, high compliance, small adverse reactions, and can reduce the incidence of hypertension complications and mortality, it has broad market prospects. [0003] Eucommia ulmoides in compound eucommia capsules contains pinoresinol diglucoside, Scutellaria baicalensis contains baicalin, and Uncaria contains rhynchophylline and isorhynchophylline and other active ingredients. These active ingredien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/35G01N21/3563G01N21/359
Inventor 王青博
Owner FUREN PHARMA GROUP
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