Andrographolide derivative and preparation method and application thereof

Abstract

The invention discloses an andrographolide derivative and a preparation method and application thereof. The derivative has a structure expressed by the formula (1), wherein R1 is C1 to C11 chain hydrocarbon or C1 to C11 chain hydrocarbon with terminals substituted by ternary to heptabasic ring groups; and R2 and R3 are hydrogen, organic acid radical, inorganic acid radical, alkyl or acryl. The andrographolide derivative can be made into tablets, capsules, granules, fine granules, powder, pills, patches, oral liquid or injection.

Description

technical field The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an andrographolide derivative and a preparation method and application thereof. Background technique Andrographolide (Andro) is one of the main active ingredients in Andrographis paniculata of the Acanthaceae plant, which has antipyretic and anti-inflammatory effects, including rheumatoid arthritis, pharyngitis, diarrhea, bacterial and viral infections. Recently, studies have shown that andrographolide has broad-spectrum anticancer effects, and the therapeutic effect is good. In India and Malaysia, andrographolide is widely used in the treatment of diabetes. In the past 30 years, andrographolide has been widely used clinically in China. A study of the antibacterial activity of andrographolide. Andrographis paniculata extract was used to treat acute upper respiratory tract infection combined with sinusitis. The results showed that Andrographis pani...

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Problems solved by technology

Andrographolide also increases the production of TNF-α and the expression of CD4 markers leading to the toxicity of lymphocytes to tumor cells, which may be the indirect cause of its antitumor activity

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