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Gel paste preparation and preparation method thereof

A technology of ointment and gel, which is applied in ointment delivery, pharmaceutical formula, aerosol delivery, etc. It can solve the problems of poor water absorption and inability to use the lesion with exudate, and achieve stable properties, excellent effects and high safety. Effect

Inactive Publication Date: 2010-12-15
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional ointment preparations with oily bases cannot be applied to wounds with exudate. For drugs that are unstable in contact with water, the defects of oily bases are more obvious. Traditional oily bases mainly include hydrocarbons, such as vaseline, paraffin, liquid paraffin , lanolin, beeswax and spermaceti have the disadvantage of poor water absorption and cannot be used on the affected area with exudate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: glycerol, sodium alginate, chitosan, distilled water, Tween system

[0013] Glycerol is selected as the moisturizing agent, and the addition amount does not exceed 20% of the total system mass. Sodium alginate and chitosan are added in a certain proportion, wherein the addition amount of sodium alginate does not exceed 5% of the total system mass, and the addition amount of chitosan No more than 3% of the total system mass, the molecular weight of chitosan ranges from 30 million to 1 million, distilled water is used as the water phase, 1% of the total system mass is added as an emulsifier Tween, and the rest is an aqueous base that can be used for drugs, proteins aqueous solution, etc. The weight percentage of auxiliary material and drug is 100%, and the gel ointment preparation is prepared by stirring at a speed of not less than 500 rpm for more than 30 minutes, and the ointment preparation is a uniform translucent gel-like system. Among them, the cross-...

Embodiment 2

[0014] Embodiment 2: triglyceride, potassium alginate powder, chitosan distilled water, Span system

[0015] The humectant is selected from triglycerides, the amount added does not exceed 20% of the total system mass, and potassium alginate and chitosan are added in a certain proportion, wherein the amount of potassium alginate added does not exceed 5% of the total system mass, and chitosan is added The amount does not exceed 3% of the total system mass. The molecular weight of chitosan ranges from 30 million to 1 million. Distilled water is used as the aqueous phase, and 1% of the total system mass is added with emulsifier Span, and the rest is medicine, protein aqueous solution, and auxiliary materials. The sum of the percentages by weight of the drug and the drug is 100%, and the gel ointment preparation is prepared by stirring for more than 30 minutes at a speed of not less than 500 rev / s. Among them, the cross-linking of sodium alginate and chitosan increases the stabilit...

Embodiment 3

[0016] Embodiment 3: honey, potassium alginate powder, carboxymethyl chitosan distilled water, AOT (sodium diisooctyl sulfosuccinate)

[0017] Honey is selected as the humectant, and the amount added does not exceed 20% of the total system mass. Potassium alginate and hydroxy chitosan are added in a certain proportion, wherein the amount of potassium alginate added does not exceed 5% of the total system mass, and the amount of hydroxy chitosan added No more than 3% of the total system mass, the molecular weight range of hydroxychitosan is 30 million to 1 million, distilled water is used as the water phase, and 1% of the total system mass is added with emulsifier Span, and the rest is drug, protein aqueous solution, and auxiliary materials The sum of the percentages by weight of the drug and the drug is 100%, and the gel ointment preparation is prepared by stirring for more than 30 minutes at a speed of not less than 500 rev / s. Among them, the cross-linking of sodium alginate a...

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Abstract

The invention relates to a gel paste preparation. The preparation comprises a water-soluble base, an emulsifier and a humectant, wherein a preparation method of the gel paste comprises the following steps of: adding the humectant of which the amount does not surpass 20 percent of the weight of a finished product into alginate of which the amount does not surpass 5 percent of the weight of the finished product and chitosan of which the amount does not surpass 3 percent of the weight of the finished product serving as main auxiliary materials; and adding the emulsifier of which the amount does not surpass 20 percent of the weight of the finished product into a mixed system to obtain the gel paste. The gel paste preparation prepared by the method has the advantages of simple formula, small dosage, little effect on medicaments and high safety.

Description

1. Technical field [0001] The invention belongs to the technical field of pharmaceutical dosage form preparation, and in particular relates to a water-based gel pharmaceutical dosage form and a preparation process thereof. 2. Background technology [0002] Gel for external use refers to a homogeneous or suspended translucent semi-solid thick preparation made of drugs and suitable auxiliary materials, mainly for external use. Gels can be divided into single-phase dispersion system and two-phase dispersion system. Gels belonging to two-phase dispersion system are small-molecule inorganic drug colloid particles that exist in the liquid in a network structure and are thixotropic, also known as suspension coagulation. Glue, such as aluminum hydroxide gel. The gel agent for local application is a single dispersion system, which is divided into water-based gel agent and oil-based gel agent. The multi-purpose hydrogel hydrogel matrix includes carbomer, cellulose derivatives, glyce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61P17/02
Inventor 王婷何农跃
Owner SOUTHEAST UNIV
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