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MiRNA expression model for diagnosing hepatic diseases independently

A technology of liver disease and expression level, which is applied in the field of medical diagnosis and can solve problems such as no functional research reports.

Inactive Publication Date: 2010-12-22
GENERAL HOSPITAL OF PLA
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Problems solved by technology

[0007] The miR-885-5p gene is located on p25.3 of chromosome 3, which was discovered by Berezikov E et al.'s cloning and sequencing, but there is no report on its function

Method used

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  • MiRNA expression model for diagnosing hepatic diseases independently
  • MiRNA expression model for diagnosing hepatic diseases independently
  • MiRNA expression model for diagnosing hepatic diseases independently

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Embodiment Construction

[0020] In order to understand the present invention, the present invention is further illustrated below with examples, but the present invention is not limited. research object

[0021] Serum samples included 24 healthy controls (NC), 23 CHB, 26 cirrhosis (LC) and 46 hepatocellular carcinoma (HCC) patients. In addition, 17 gastric cancer (GC) serum samples were included as disease controls. Among them, the inclusion criteria of healthy controls, liver cirrhosis, and hepatocellular carcinoma are the same as those mentioned above. All CHB cases were positive for HBsAg. All patients with gastric cancer were admitted to the hospital for treatment for the first time. They had not received any drug or surgical treatment before admission, and all liver-related diseases were excluded. All patients were confirmed by pathological examination after operation. Among them, the serum of the healthy control came from the staff of our hospital. Except for some individuals suffering from di...

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Abstract

The invention relates to a miRNA expression model for diagnosing hepatic diseases independently. In the invention, an expression model of a miR-885-5p which is one of the circulating miRNAs associated with hepatic diseases is built by analyzing the types and relative expression levels of potential circulating miRNAs in a serum sample of a patient with cirrhosis or hepatocellular carcinoma and comparing the expression levels of the potential circulating miRNAs with the expression abundance of the circulating miRNAs in healthy reference serum. The model is formed by the expression indexes of the miR-885-5p, wherein the expression level of the miR-885-5p is higher than that of a healthy reference and is less tan 0.0001. ROC curve analysis shows that the hepatic disease HCC, LC and CHB identification efficacy AUC of the miR-885-5p and the healthy reference is 0.904, and the sensitivity and specificity of the miR-885-5p and the healthy reference are 90.5 percent and 79.2 percent respectively.

Description

technical field [0001] The invention belongs to the technical field of medical diagnosis, and in particular relates to a miRNA expression model for independently diagnosing liver diseases. Background technique [0002] Liver-related diseases such as chronic hepatitis B, hepatitis C (referred to as hepatitis C), liver fibrosis, liver cirrhosis, and hepatocellular carcinoma are still major diseases that seriously endanger people's health. Studies have shown that under normal physiological conditions, miRNAs are closely related to basic life activities such as liver development, hepatocyte phenotypic differentiation, liver metabolism and stress, while the abnormal expression regulation of miRNAs is related to liver virus infection and replication, HCC (hepatocellular carcinoma ), the occurrence and development of which are closely related. For example, miR-122, which is specifically expressed in the liver, may affect the growth and development of liver cells, cholesterol and l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 田亚平桂俊豪张朋军
Owner GENERAL HOSPITAL OF PLA
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