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The use of the yellow thorn fruit to improve lipid metabolism disorder

A lipid metabolism disorder and application technology, which is applied in the field of preparation of drugs for improving lipid metabolism disorder in the fruit of C. japonica, and achieves the effects of wide application range, reduced activity, and improvement of lipid metabolism disorder

Active Publication Date: 2018-12-28
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the improvement of lipid abnormalities in the fruit of Huangci

Method used

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  • The use of the yellow thorn fruit to improve lipid metabolism disorder
  • The use of the yellow thorn fruit to improve lipid metabolism disorder
  • The use of the yellow thorn fruit to improve lipid metabolism disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Pharmacodynamic study of the fruit of the present invention

[0016] 1) Experimental drug: take the fruit of C. japonica, dry it and pulverize it to obtain fruit powder for later use. The dosage is calculated on the basis of rat body weight, and the low dose and high dose are respectively 0.4g / kg and 1.6g / kg (in the amount of japonica fruit powder) by intragastric administration.

[0017] 2) Animals: four-week-old Kunming rats, male, normal grade, 135 g, provided by Gansu College of Traditional Chinese Medicine. The experiments were carried out after being placed in mouse cages for one week in the laboratory (8 mice per cage, temperature 22±1° C., humidity 42%±2%). Divided into five groups: blank group (intravenous injection of citric acid buffer without modeling, ultrapure water gavage), model group (tail vein injection of STZ for modeling, ultrapure water gavage), positive drug group (tail vein injection Injection of STZ for modeling, glibenclamide 20mg / kg...

Embodiment 4

[0042] Example 4 The experiment of improving lipid metabolism disorder by polysaccharides from the fruit of C. japonica

[0043] 1) Experimental drug: polysaccharide from the fruit of C. japonica, prepared by the following method:

[0044] A, degreasing of the fruit of the yellow thorn: take 400g of the ripe fruit of the yellow thorn (i.e. barberry straight ear) and dry it, crush it and sieve it; get the fruit of the yellow thorn and mix it with petroleum ether, extract it by ultrasonic after mixing, and centrifuge to remove the extract and the residue Filter, evaporate the petroleum ether to obtain the degreased thorn fruit residue;

[0045] B. Monosaccharide removal from the thorn fruit: the residue of the defatted thorn fruit is mixed with ethanol; Residue of removing monosugar thorn fruit;

[0046] C. Extraction of the crude polysaccharides of C. japonica: mix the residue obtained in step B with pure water from the fruit of C. japonica from which monosaccharides have bee...

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PUM

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Abstract

The invention provides application of yellow thorn fruits or extracts of the fruits to preparing medicines or health care products or food for treating dyslipidemia. The research shows that the yellow thorn fruits have the effect of treating the dyslipidemia, and cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and rising high-density lipoprotein (HDL) can be reduced; the enzymatic activity relevant to lipid metabolism can be improved, that is, the activity of the lipoprotein lipase and hepatic lipase can be improved; meanwhile, the activity of glutamic oxalacetic transaminase and glutamic-pyruvic transaminase can be reduced, no hurt to the liver tissue exists, and the fruits can be used as the good-safety medicines or the health care products or the food for treating the dyslipidemia.

Description

technical field [0001] The invention belongs to the field of health care products, and in particular relates to the use of japonica fruit in the preparation of medicines for improving lipid metabolism disorders. technical background [0002] Lipid metabolism includes lipid digestion and absorption in the small intestine, entering the blood circulation from the lymphatic system (transported by lipoproteins), being transformed by the liver, stored in adipose tissue, and utilized by the tissue when needed. The main function of lipids in the body is to oxidize and supply energy. Adipose tissue is the energy storehouse of the body. Fat can also cooperate with the skin, bones, and muscles to protect internal organs, prevent body temperature from escaping, and help absorb fat-soluble vitamins in food. Phospholipids are an important structural component of all cell membranes, and cholesterol is a precursor to bile acids and steroid hormones (corticoids and gonadal hormones). Lipid ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/29A23L19/00A23L33/105A23L33/10A61P3/06A61P9/10
Inventor 索有瑞韩丽娟叶英胡娜
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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