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Novel medicine composition for treating hepatic diseases

A technology for liver disease and composition, applied in the field of medicine, to achieve good antiviral effect, improve liver function, and have remarkable curative effect.

Inactive Publication Date: 2011-08-10
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, using the interaction of matrine, reduced glutathione and tiopronin, the compatibility of prescriptions for the preparation of drugs for the treatment of liver diseases has not been reported

Method used

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  • Novel medicine composition for treating hepatic diseases
  • Novel medicine composition for treating hepatic diseases
  • Novel medicine composition for treating hepatic diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] The preparation of embodiment 1 KHL composition aqueous injection

[0105] prescription:

[0106]

[0107] Preparation Process:

[0108] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0109] 2) Add reduced glutathione into water for injection with a dosing volume of 30%, heat and stir to dissolve completely. Add tiopronin and matrine into a small amount of water for injection, add the prescribed amount of polysorbate 80, heat and stir to dissolve.

[0110] 3) Combine the above solutions and add water for injection to the full amount.

[0111] 4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0112] 5) Decarburization by sand filter stick filtration. Measure and adjust the pH of the solution.

[0113] 6) Fine filtration through a 0.45um microporous membrane.

[0114] 7) Check the clarity of the solution and test t...

Embodiment 2

[0119] The preparation of embodiment 2 KHL composition powder injection

[0120] prescription:

[0121]

[0122] Preparation Process:

[0123] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0124] 2) Weigh the raw materials and auxiliary materials according to the prescription quantity.

[0125] 3) Add reduced glutathione into water for injection with a dosing volume of 30%, heat and stir to dissolve completely. Add tiopronin and matrine into a small amount of water for injection, add the prescribed amount of polysorbate 80, heat and stir to dissolve. Combine the above solutions and add sterile water for injection to the full amount.

[0126] 4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0127] 5) Decarburization by sand filter stick filtration. Measure and adjust the pH of the solution.

[0128] 6) Fine filtration through a 0.22um micropor...

Embodiment 3

[0133] Preparation of Example 3 KHL Composition Sodium Chloride Infusion

[0134] prescription:

[0135]

[0136] Preparation Process:

[0137] 1) Dispose of the pipes and containers used for liquid preparation the day before, and rinse them with fresh water for injection before use.

[0138] 2) Add reduced glutathione into water for injection with a dosing volume of 30%, heat and stir to dissolve completely. Add tiopronin and matrine into a small amount of water for injection, add the prescribed amount of polysorbate 80, heat and stir to dissolve. Dissolve sodium chloride completely with an appropriate amount of water for injection, combine the above solutions, and add water for injection to the full amount.

[0139] 3) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0140] 4) Decarburization by sand filter rod filtration. Measure and adjust the pH of the solution.

[0141] 5) Fine filtration through a 0.45um microporo...

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Abstract

The present invention belongs to the field of medicine technology, and is especially a kind of medicine composition and its preparation process. The medicine composition is prepared with kurarinone 4-400 weight portions, glutathione 3-300 weight portions, and tiopronin 1-100 weight portions. The medicine composition may be prepared into different pharmaceutically acceptable forms, preferably injection and oral preparation. It has the pharmacological activities of antagonizing virus, improving liver cell function, antagonizing liver fibrosis, regulating immunity, diminishing inflammation, etc.and may be used in treating various hepatic diseases, viral hepatosis, medicinal hepatosis, alcoholic hepatosis, etc.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition mainly composed of matrine, reduced glutathione and tiopronin, a preparation method and application thereof. 2. Background technology [0002] Viral hepatitis caused by hepatitis virus has always been one of the serious infectious diseases in the world, and it is a common and frequently-occurring disease in my country. About 80% of adults in my country have been infected with hepatitis A virus, 50% have been infected with hepatitis B virus, and 3% have been infected with hepatitis C virus. If known and unknown hepatitis virus infections such as D and E are added, the overall The rate of infection and the number of infected people are astonishing. Such a high infection rate not only causes hundreds of thousands of new cases of acute hepatitis, chronic hepatitis, severe hepatitis, liver cirrhosis, and liver cancer every year, but also forms a huge num...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/06A61P1/16A61P31/14A61P31/20A61K31/4375A61K31/197
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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