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Application of 2,3,5,4'-tetrahydroxy diphenyl ethylene-2-1-beta-D-glucoside for preparation of drug reducing blood fat

A technology of tetrahydroxystilbene and blood lipid-lowering drugs, applied in the field of natural compounds

Inactive Publication Date: 2006-05-24
广州中医药大学热带医学研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are no public reports of pharmacological experiments and clinical applications related to the treatment of hyperlipidemia for this component monomer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: Effect on serum lipids of hypercholesterolemia experimental animals [1]

[0010] Male SD rats were randomly divided into normal group, model group, positive drug (fenofibrate) control group, test drug (2,3,5,4′-tetrahydroxystilbene-2-O-β- D-glucoside) low-dose group, test drug (2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside) high-dose group (the same below). Except the normal group, the other 4 groups were administered with fat emulsion for 3 consecutive weeks. From the second week onwards, different treatments were given to each group: the normal group and the model group were given intragastric administration of normal saline (2ml / day), the control group was given intragastric administration of fenofibrate (100mg / kg·day), and the low-dose drug group was given intragastric administration. Oral administration of 80 mg / kg·day, and 160 mg / kg·day of the test drug group were administered by intragastric administration for 2 consecutive weeks.

[0011] Seru...

Embodiment 2

[0016] Embodiment 2: The influence of test drug on liver lipase activity

[0017] The liver tissue of rats with hypertriglyceridemia was collected to prepare liver tissue homogenate, and the operation was performed according to the instructions of the liver lipase (HL) activity assay kit (product of Nanjing Jiancheng Bioengineering Institute). The results are shown in Table 2.

[0018] Group

HL

normal group

model group

positive drug control group

The low dose group of the test drug

test drug high dose group

0.166±0.034

0.086±0.019 Δ

0.110±0.017 Δ

0.130±0.036 *

0.109±0.019 Δ

[0019] Δ P* P<0.01.

[0020] As can be seen from Table 2, the average hepatic lipase activity of the animals in the low-dose test drug group was significantly higher than that in the model group (P<0.05), and compared with the normal group, there was no significant difference.

[0021] In summary, the tested drug 2,3,5,4′-tetrahydrox...

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Abstract

The present invention relates to a kind of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside for reducing blood lipid, which is characterized in that it has the function of inhibiting the increase of serum total cholesterol, reducing serum low The functions such as density lipoprotein cholesterol and improving the activity of liver lipase can be made into medicine with this active monomer.

Description

Technical field [0001] The present invention relates to a natural compound with medicinal value, especially a stilbene glycoside compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucose with hypolipidemic effect Glycosides. Background technique [0002] A large number of epidemiological surveys and research data show that hyperlipidemia is an important risk factor for many diseases such as atherosclerosis, coronary heart disease, hypertension, diabetes, and cholelithiasis. The prevention and treatment of hyperlipidemia is the focus of current medical research. The current blood lipid-lowering drugs mainly include phenoxyacetic acid represented by fenofibrate, statin synthetic drugs represented by simvastatin, and traditional Chinese medicine preparations such as evening primrose and special red yeast rice (Xuezhikang). The Chinese Pharmacopoeia has recorded blood lipid-lowering traditional Chinese medicine prescriptions such as Xuezhining containing Polygonum multiflorum. P...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/20A61K31/7034A61K9/20A61K9/08A61K9/16A61K9/48A61P3/06
Inventor 胡英杰符林春高瑄卢元嫒
Owner 广州中医药大学热带医学研究所
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