Traditional Chinese medicine composite capable of reducing blood fat and preparation method thereof
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A composition and blood lipid-lowering technology, which can be used in drug combinations, pharmaceutical formulas, drug delivery, etc., can solve problems such as hidden safety hazards, and achieve the effects of high safety, broad market prospects, and wide sources
Inactive Publication Date: 2009-08-19
ANJI GREEN LIFE BIOTECH
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It can be seen from the above literature that although simvastatin has been domestically produced, its use cost still causes a great economic burden for patients who need to take it for a long time. Although the incidence of various adverse reactions is low, long-term and large-scale use is still expensive Has a certain security risk
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Embodiment 1
[0014] Therapeutic effect of different proportions of blood lipid-lowering traditional Chinese medicine composition on acute hyperlipidemia model mice induced by intraperitoneal injection of egg yolk emulsion
[0015] Take 80 male ICR mice of 20g~22g, and group them after adaptive feeding for 5 days;
[0016] Blank group: normal saline;
[0017] Model group: normal saline;
[0018] Positive drug control group: Xuezhikang, 1000mg·kg -1 ;
[0019] Artesunate group: artesunate, 2mg per piece -1 ;
[0027] Dosing volume: 0.2ml, 1 time -1 , continuous administration for 14 days, fasting and water after the 14th day of administration, 2 hours after the last administration, intraperitoneal injection of 0.5ml...
Embodiment 2
[0036] Preparation method of traditional Chinese medicine composition tablet for reducing blood fat
[0037] Take 200g of artesunate and 200g of ursolic acid, mix, grind finely, pass through a 120 mesh sieve, mix with 40g of hydroxypropyl methylcellulose, 100g of microcrystalline cellulose, and 15g of croscarmellose sodium , adding an appropriate amount of 60% (v / v) ethanol solution to make a soft material, the appropriate amount means that the amount of ethanol added reaches the standard of the soft material; pass through a 24-mesh sieve to granulate, dry at 50°C for 2 hours, and pass the dried granules through a 30-mesh sieve for granulation , add 2.5g of magnesium stearate, mix well, and press into tablets.
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Abstract
The invention discloses a Chinese medicine composition for reducing blood fat in the technical field of medicine and a preparation method thereof. The composition comprises an artesunate bulk drug and an ursolic acid bulk drug, wherein the weight proportion of the artesunate bulk drug to the ursolic acid bulk drug is 1: 25-25: 1. The preparation method for the composition comprises the following steps that: the artesunate bulk drug and the ursolic acid bulk drug are mixed according to the weight percentage, the mixture is porphyrized and passes through a 120-mesh sieve, thus the composition can be obtained; or the artesunate bulk drug and the ursolic acid bulk drug are taken according to the weight proportion, and are porphyrized and pass through the 120-mesh sieve respectively, then fine powders are mixed to sieve for 3 times, thus the composition can be obtained. An active ingredient of the composition has remarkable cooperative synergism; and the composition can be prepared into injection drug delivery and oral drug delivery dosage forms when matched with pharmaceutically acceptable excipient carriers, has low cost, and can be used for preparing medicines for reducing blood fat.
Description
technical field [0001] The invention relates to a traditional Chinese medicine composition in the technical field of medicine and a preparation method thereof, in particular to a blood lipid-lowering traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] At present, the number of middle-aged and elderly people with hyperlipidemia is increasing day by day. Since hyperlipidemia is likely to cause serious health hazards such as myocardial infarction and cerebral thrombosis, improving hyperlipidemia is one of the focuses of medical researchers. The use of lipid-lowering drugs Research and development has become a hot field in the development of the pharmaceutical industry. At present, the lipid-lowering drugs that are more clinically used mainly include the following categories: (1) statins: lovastatin, simvastatin, etc.; (2) acyl-CoA cholesterol acyltransferase inhibitors: avastatin; ( 3) Fibrates: fenofibrate, gemfibrozil; (4)...
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