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New use of asiatic pennywort herb extract in treatment of hyperlipidaemia and related medicines

A technology of centella asiatica extract and hyperlipidemia, which is applied in the field of medicine, can solve the problems of imperfect quality standards, prevention, and in-depth research, etc., and achieves the effects of low comprehensive cost, simple process and remarkable curative effect.

Active Publication Date: 2014-01-08
韩嘉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are dozens of Chinese herbal medicines with lipid-lowering effects, but so far, the research on them is not very in-depth. The active ingredients of blood-lipid regulation are not clear, and the quality standards are not perfect, which prevents them from going international and benefiting all mankind. the process

Method used

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  • New use of asiatic pennywort herb extract in treatment of hyperlipidaemia and related medicines
  • New use of asiatic pennywort herb extract in treatment of hyperlipidaemia and related medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Separation and extraction of centella asiatica ethanol extracts with different concentrations and water extracts

[0027] Take 5 parts of Centella asiatica (purchased from Xiamen Yanlaifu Pharmaceutical Co., Ltd.), 1kg per part, crush Centella asiatica, and add 8 times the amount of water, 30% ethanol, 50% ethanol, and 70% ethanol to each part and 95% ethanol (volume fraction) soaked at room temperature for 1 day, condensed and refluxed for heating and reflux extraction, extraction temperature 60-80 ° C, extraction time 2 hours, filtered, and the filtrate was stored; take the dregs and add water or ethanol solution of the same concentration Under the same conditions, extract once again, filter, put the filtrate into the concentration tank, combine with the first extract and concentrate in vacuum, recover ethanol and concentrate to the crude drug, that is, centella asiatica water extract, 30% ethanol extract, 50% ethanol extract , 70% ethanol extract, and 95% e...

Embodiment 2

[0028] Example 2 The effect of Centella asiatica ethanol extract on blood lipid levels in acute hyperlipidemia

[0029] 1. Experimental method

[0030] 1) Experimental animals and reagents

[0031] Sixty-four Kunming mice, male, with an average weight of 25 grams, were purchased from Shanghai Slack Experimental Animal Co., Ltd.; license number: SCXK (Shanghai) 2007-0005.

[0032] Triton T0307, ​​purchased from SIGMA company

[0033] Fenofibrate, purchased from SIGMA company

[0034] Centella asiatica extract: Centella asiatica aqueous extract, 30% ethanol extract, 70% ethanol extract, and 95% ethanol extract prepared in Example 1.

[0035] 2) Animal handling methods

[0036] Kunming mice, normal light, temperature: 18-25°C, humidity: 40-60%, given normal feed, free drinking water after adaptive feeding for 7 days, were randomly divided into 8 groups, 8 mice in each group, respectively as the normal control group , acute hyperlipidemia model group, fenofibrate group, cente...

Embodiment 3

[0047] Embodiment 3 Centella asiatica ethanol extract is on the influence of dietary hyperlipidemia blood lipid level

[0048] In this example, the golden hamster hyperlipidemia model fed with high-fat feed was used to observe the effect of Centella asiatica extract on the serum total cholesterol (TC) and triglyceride (TG) of the hyperlipidemia model golden hamster , the specific method is as follows:

[0049] 1. Experimental method

[0050] 1) Experimental animals and reagents

[0051] Sixty-four golden hamsters, male, with an average weight of 90 grams, were purchased from Songlian Experimental Animal Farm, Songjiang District, Shanghai; license number: SCXK (Shanghai) 2007-0011.

[0052] Xuezhikang, purchased from Beijing Beida Weixin Biotechnology Co., Ltd., product batch number: 20111007

[0053] Centella asiatica extract: Centella asiatica aqueous extract, 30% ethanol extract, 50% ethanol extract, 70% ethanol extract, and 95% ethanol extract prepared in Example 1.

[...

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Abstract

The invention relates to the field of medicines, and in particular relates to a new use of an asiatic pennywort herb extract in treatment of hyperlipidaemia and related medicines. The invention discloses the use of the asiatic pennywort herb extract in the preparation of a medicine for treating and preventing hyperlipidaemia, and particularly, the asiatic pennywort herb extract is 30-95 v / v% ethanol solution extract of the asiatic pennywort herb. The experiment proves that the medicine containing the asiatic pennywort herb extract has obvious antihyperlipidemic effects, and can be used for preventing and treating the hyperlipidaemia caused by multiple reasons.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the new application of centella asiatica extract for treating hyperlipidemia and related medicines. Background technique [0002] Hyperlipidemia is the main cause of various cardiovascular diseases, and the damage of the disease to the body is hidden, gradual, progressive and systemic. With the increase of blood lipids and the prolongation of abnormal blood lipids, it will cause atherosclerosis, coronary heart disease, hypertension, diabetes, stroke, fatty liver and other diseases. The incidence of these cardiovascular and cerebrovascular diseases is high, the harm is great, and the progress of the disease is dangerous. The mortality rate accounts for about half of the total human mortality. According to epidemiological statistics, the possibility of suffering from the onset of hyperlipidemia is higher than that of the normal population of the same age group, and the incidence rate is 4...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P3/06
Inventor 韩嘉金鑫
Owner 韩嘉
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