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Medicament for preventing and treating small intestine transplantation chronic rejection and application thereof

A chronic rejection and drug technology, which is applied in the field of medicine to achieve the effects of reducing vascular lumen occlusion, reducing inflammatory cell infiltration, and strongly resisting chronic rejection of small intestine transplantation

Inactive Publication Date: 2010-12-29
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about the use of n-3 polyunsaturated fatty acid substances in the prevention and treatment of chronic rejection of small bowel transplantation at home and abroad

Method used

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  • Medicament for preventing and treating small intestine transplantation chronic rejection and application thereof
  • Medicament for preventing and treating small intestine transplantation chronic rejection and application thereof
  • Medicament for preventing and treating small intestine transplantation chronic rejection and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Materials and Methods:

[0024] (1) Experimental animals

[0025] Male Fisher344 (F344) rats and Lewis rats were purchased from Beijing Weitong Lihua Company, weighing 200-300 grams; they were raised in the Animal Center of Comparative Medicine Department of Nanjing General Hospital of Nanjing Military Region, and all rats were fed in single cages, and light and dark were alternated for 12 hours , sufficient food and water.

[0026] (2) Animal grouping

[0027] The donors and recipients in the syngeneic transplantation group were both Lewis rats, as a control; the donors in the allogeneic transplantation group were F344 rats, and the recipients were Lewis rats. The allogeneic transplantation group was randomly divided into PBS group and fish oil group: the PBS group was intragastrically administered with phosphate buffer solution (PBS, 0.1M, pH7.4) every day after operation; the fish oil group was intragastrically administered with fish oil (manufactured by Sigma) eve...

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PUM

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Abstract

The invention belongs to the field of medicaments, and discloses a medicament for preventing and treating small intestine transplantation chronic rejection and application thereof. The medicament comprises an n-3 polyunsaturated fatty acid substance, preferably fish oil; and long-term researches prove that the n-3 polyunsaturated fatty acid substance, particularly n-3 polyunsaturated fatty acid-rich fish oil can effectively relieve vascular lumen occlusion caused by the small intestine transplantation chronic rejection, reduce inflammatory cell infiltration, and reduce interstitial fibrosis of mesenteric vessels, namely relieve small intestine transplantation vascular atherosclerosis, and has good effect of resisting the small intestine transplantation chronic rejection. The invention provides an effective medicament for preventing and treating the small intestine transplantation chronic rejection.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to medicine for preventing and treating chronic rejection of small intestine transplantation and its application. Background technique [0002] Small bowel transplantation is an ideal treatment option for severe intestinal dysfunction that develops into intestinal failure. Because the small intestine and mesentery contain a large amount of lymphoid tissue, the incidence of rejection after transplantation is high, which directly affects the success rate of small bowel transplantation. With the development of immunosuppressive drugs, the acute rejection of small bowel transplantation has been effectively controlled, but there is still no effective treatment for chronic rejection after transplantation at home and abroad, which restricts the long-term survival of patients with small bowel transplantation. Finding effective drugs to prevent and treat chronic rejection of small bowel transplantation...

Claims

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Application Information

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IPC IPC(8): A61K35/60A61K36/55A61K36/52A61K36/48A61K36/31A61K36/02A61P37/06
Inventor 黎介寿李秋荣王晨阳
Owner NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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