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Traditional Chinese medicine composition, preparation method and application thereof in preparation of medicine for treating liver injury

A technology of composition and traditional Chinese medicine, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of poor effect and patient discomfort, and achieve the effect of treating liver injury, micro fatty degeneration, inflammatory cell infiltration and activity reduction

Active Publication Date: 2022-01-21
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Endoscopy, radiological intervention and surgery are currently effective methods for the treatment of extrahepatic cholestasis, but the treatment process will make patients feel uncomfortable; there are currently a few drugs that are related to the treatment of extrahepatic cholestasis, but other methods are needed to cooperate with the treatment. and less effective

Method used

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  • Traditional Chinese medicine composition, preparation method and application thereof in preparation of medicine for treating liver injury
  • Traditional Chinese medicine composition, preparation method and application thereof in preparation of medicine for treating liver injury
  • Traditional Chinese medicine composition, preparation method and application thereof in preparation of medicine for treating liver injury

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preparation example Construction

[0029] The raw materials for the preparation of the traditional Chinese medicine composition provided by the present invention include 12-16 parts of the turtle shell, preferably 13.5-15.5 parts, more preferably 14.5-15 parts.

[0030] The preparation raw material of the traditional Chinese medicine composition provided by the invention comprises 8-12 parts of bergamot, preferably 8.5-11.5 parts, more preferably 9.5-10.5 parts.

[0031] The preparation raw material of the traditional Chinese medicine composition provided by the present invention comprises 13-16 parts of mulberries, preferably 13.5-15.5 parts, more preferably 14.5-15 parts.

[0032] The preparation raw material of the traditional Chinese medicine composition provided by the present invention comprises 4-6 parts of Panax notoginseng, preferably 4.5-5.5 parts, more preferably 4.8-5.2 parts.

[0033] The preparation raw material of the traditional Chinese medicine composition provided by the present invention comp...

Embodiment 1

[0059] Take vinegar turtle 15g, bergamot 10g, mulberry 15g, Panax notoginseng 5g, Coptis 6g, Scutellaria baicalensis 10g, Polygonum cuspidatum 10g, Hedyotis diffusa 15g, Dendrobium 5g, Rhubarb 5g, decoct in 10 times the volume of water for 1 hour, filter out Clear, repeat decoction and filter 3 times. Combine the medicinal juices obtained three times, concentrate to 1g / mL with low heat, add absolute ethanol to make it reach 75% of the total volume after cooling, stir overnight with magnetic force, centrifuge at 25000g for 20 minutes, take the supernatant, evaporate the ethanol at constant temperature, and use distilled water Adjust the concentration of the drug solution to 1g / mL, and store in a -20°C refrigerator after autoclaving.

Embodiment 2

[0061] Take vinegar turtle 12g, bergamot 11g, mulberry 14g, Panax notoginseng 4.5g, Coptidis 6.5g, Scutellaria baicalensis 9g, Polygonum cuspidatum 11g, Hedyotis diffusa 14g, Dendrobium 4.5g, Rhubarb 5g, decoct in 9 times the volume of water for 1.2 hours, Filter the supernatant, repeat decoction and filter 3 times. Merge the medicinal juices obtained three times, concentrate on low heat to 1.2g / mL, add absolute ethanol after cooling to make it reach 80% of the total volume, stir overnight, centrifuge at 22000g for 15 minutes, take the supernatant, evaporate the ethanol at a constant temperature, and use Adjust the concentration of the solution to 0.7g / mL with distilled water, and store in a -20°C refrigerator after autoclaving.

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Abstract

The invention provides a traditional Chinese medicine composition, a preparation method and application thereof in preparation of a medicine for treating liver injury, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw materials: 12-16 parts of vinegar turtle shell, 8-12 parts of bergamot, 13-16 parts of mulberry, 4-6 parts of pseudo-ginseng, 5-7 parts of coptis chinensis, 8-12 parts of scutellaria baicalensis, 8-12 parts of polygonum cuspidatum, 13-18 parts of oldenlandia diffusa, 4-6 parts of dendrobe and 4-6 parts of rheum officinale. The traditional Chinese medicine composition overcomes the problems of poor patient feeling, poor oral preparation effect and the like of a treatment method in the prior art. Through reasonable compatibility of the medicine components in a specific proportion, the liver injury can be effectively treated, a protective effect on liver functions is achieved, treatment on the liver injury is achieved through ABC transporter protein, primary bile acid biosynthesis and other pathways, and the protective effect on cholestatic liver injury is related to oxidation resistance.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a preparation method and its application in the preparation of medicines for treating liver damage. Background technique [0002] Cholestatic liver disease is a disorder of bile production, secretion, and excretion caused by various reasons. It cannot be actively discharged to the intestinal cavity through the bile canaliculus, and it accumulates in the liver and flows back into the blood, resulting in a series of organic damage and metabolic disorders. Dysregulated and dysfunctional diseases of the hepatobiliary system. Cholestasis includes disturbances in the secretion and excretion of bilirubin, bile salts, and other components. The etiology mainly includes heredity, immunity, degeneration, infection, calculus and tumor. The disease can involve any part of the entire biliary system from the bile canaliculus fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P1/16A61K35/586
CPCA61K35/586A61K36/752A61K36/605A61K36/258A61K36/718A61K36/539A61K36/704A61K36/748A61K36/8984A61K36/708A61P1/16A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00Y02A50/30
Inventor 徐华明刘延鑫张丽红周茜如杨念冯龙梁冰卢昱含乔新柳
Owner HENAN UNIV OF CHINESE MEDICINE
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