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Analgesic and anti-inflammatory medicament and preparation method thereof

A drug and composition technology, applied in the field of traditional Chinese medicine and the preparation of the drug, can solve the problems of damage to the hematopoietic system and gastric mucosa, side effects cannot be underestimated, renal insufficiency, etc., to reduce the number of writhing reactions, clear prescriptions, increase pain threshold effect

Active Publication Date: 2011-01-05
于明希
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the western medicines for this kind of diseases are effective quickly, the side effects should not be underestimated.
Long-term use will cause harm to the body, can cause allergic reactions, damage the hematopoietic system and gastric mucosa, and lead to serious consequences such as renal insufficiency

Method used

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  • Analgesic and anti-inflammatory medicament and preparation method thereof
  • Analgesic and anti-inflammatory medicament and preparation method thereof
  • Analgesic and anti-inflammatory medicament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Preparation of tablets of two-flavor Chinese medicine composition

[0032] Take 100g rhubarb and 100g gardenia two medicinal materials, clean them into slices or sections, and extract the above-mentioned medicinal materials with a volume percentage of 85% ethanol aqueous solution refluxing for 3 times. The quality of the first extraction solvent is 6 of the quality of the medicinal materials. The quality of the solvent for the second extraction is 6 times the quality of the medicinal material, and the quality of the solvent for the third extraction is 5 times the quality of the medicinal material for 2 hours. The extraction is completed for 1 hour. After filtering, collect the filtrate, combine the three filtrates, and recover ethanol. The filtrate is concentrated at 70°C into a thick paste with a relative density of 1.20-1.30, dried and crushed to obtain the powder of the pharmaceutical composition (passed through a 100-mesh sieve). Appropriate amount of starch...

Embodiment 2

[0033] Example 2. Preparation of capsules of two-flavor Chinese medicine composition

[0034] Take 20g rhubarb and 100g gardenia two medicinal materials, clean them into slices or sections, and extract the above medicinal materials once with water reflux. The quality of the extraction solvent is 8 times the quality of the medicinal materials. Extract for 3.5 hours. After the extraction is completed, filter it. Collect the filtrate, concentrate the filtrate at 70°C into a thick paste with a relative density of 1.20-1.30, dry and pulverize to obtain the powder of the pharmaceutical composition (pass a 100-mesh sieve), add appropriate amount of starch and other auxiliary materials, mix, granulate, and pack In the capsule shell, make a capsule.

Embodiment 3

[0035] Example 3. Preparation of capsules of two-flavor Chinese medicine composition

[0036] Take 100g rhubarb and 60g gardenia two medicinal materials, clean slices or sections, extract the above medicinal materials with water 3 times, the first extraction solvent quality is 8 times the quality of the medicinal materials, extraction for 2 hours, the second extraction solvent The quality of the extract is 5 times the quality of the medicinal material. Extract for 1 hour. The quality of the third extraction solvent is 5 times the quality of the medicinal material. Extract for 1 hour. After each extraction, filter, collect the filtrate, and combine the three filtrates , Concentrate the filtrate into an extract with a relative density of 1.10 to 1.20, then add ethanol to the extract to make the alcohol content in the mixed system 50%, put it in a closed container, stand still for 24 hours, filter the filtrate, and recover the ethanol. Concentrate the filtrate at 70°C into a thick p...

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Abstract

The invention discloses a medicinal composition with effects of relieving pain, resisting inflammation, activating blood and dissolving stasis and a preparation method and application thereof. The medicinal composition is prepared from the following raw materials in part by weight: 20 to 100 parts of rhubarb and 20 to 100 parts of gardenia. In order to better perfect the compatibility of medicaments, the medicinal composition also can comprise the following raw materials in part by mass: 20 to 100 parts of rhubarb, 20 to 100 parts of gardenia, 10 to 30 parts of common monkshood mother root, 10 to 30 parts of kusnezoff monkshood root, 20 to 80 parts of divaricate saposhnikovia root, 20 to 80 parts of incised notopterygium rhizome, 30 to 70 parts of Chinese angelica and 30 to 70 parts of szechuan lovage rhizome. Animal experiments prove that the medicinal composition can obviously reduce various hemorheological indexes of a qi-stagnation blood-stasis model rat, has the effects of promoting qi and blood circulation, can increase pain threshold of the rat and reduce the writhing response times of the rat, has obvious analgesic effect, can inhibit ear swelling of the rat caused by dimethyl benzene and has obvious anti-inflammatory and anti-swelling effects.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine and a preparation method of the medicine, in particular to a medicine with analgesic, anti-inflammatory and blood stasis activities and a preparation method thereof. Background technique [0002] Bone hyperplasia, rheumatism, neck, shoulder, waist and leg joint pain, neuropathic pain, bruises, etc. are common and frequently-occurring diseases, which seriously affect people's work, study and daily life. Although western medicine for treating such diseases has a quick effect, the side effects should not be underestimated. Long-term application is harmful to the body, can cause allergic reactions, damage the hematopoietic system and gastric mucosa, and cause serious consequences such as renal insufficiency. [0003] TCM treatment of diseases is generally based on the principle of seeking the root of the disease, with clear curative effects and few side effects. Therefore, it is of great significance to dev...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P29/00
Inventor 于春江
Owner 于明希
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