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Application of resina draconis to preparing compound enema for treating ulcerative colitis

A technology for ulcerative colitis and enema, applied in the field of medicine, can solve the problems of patients losing work and learning ability, unable to maintain, and increasing the incidence rate

Inactive Publication Date: 2011-02-02
王雪明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

6-mercaptopurine (6-MP) or azathioprine, etc. for those who cannot maintain the above drugs or who are dependent on steroid hormones
However, all such treatment methods cannot be cured and the side effects of drugs are relatively large, and many patients cannot adhere to the treatment for a long time
However, with the rapid westernization of Chinese people's life and eating habits, the incidence of the disease has increased rapidly, and the proportion of severe and total colonic types has also increased significantly. In addition, the age of onset is mostly among young and middle-aged people, making quite a lot of patients lose their jobs. learning ability, the burden of disease on society is increasing year by year

Method used

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  • Application of resina draconis to preparing compound enema for treating ulcerative colitis
  • Application of resina draconis to preparing compound enema for treating ulcerative colitis
  • Application of resina draconis to preparing compound enema for treating ulcerative colitis

Examples

Experimental program
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Effect test

experiment example 1

[0019] Experimental Example 1 Regulatory Effect of Compound Xuejie Enema on Cytokines in Animal Models of Ulcerative Colitis

[0020] 1 Materials and methods

[0021] 1.1 As experimental animals, 40 male Wistar rats (body weight 100±10 g) were selected and provided by the Experimental Animal Center of the Second Affiliated Hospital of the PLA General Hospital.

[0022] 1.2 Main reagents and instruments 2,4-Dinitrochlorobenzene (DNCB), provided by Beijing Biochemical Reagent Store Company; Acetone: Analytical grade, product of Beijing Chemical Factory; IL-1β, IL-4, IL-6, IL-10 . RIA kit: provided by Beijing Bonding Tech Biotechnology Co., Ltd. Domestic FJ-630 automatic r counter.

[0023] 1.3 Experimental grouping and administration 40 rats were randomly divided into 4 groups, 10 in each group, that is, the normal control group (normal rats were treated with normal saline 1ml / kg), and the model control group (the ulcer model animals were treated with normal saline 1ml / kg). ...

experiment example 2

[0039] Experimental Example 2 Effect of Compound Xuejie Enema on Hemorheology in Patients with Chronic Nonspecific Ulcerative Colitis

[0040] From April 2003 to November 2005, in the Gastroenterology Department of our hospital, the retention enema of compound Xuejie enema solution was used to treat chronic non-specific ulcerative colitis (UC), and achieved remarkable curative effect.

[0041] 1 Materials and methods

[0042] 1.1 General information Eighty-three UC patients met the diagnostic criteria established by the 1999 National Symposium on Chronic Noninfectious Intestinal Diseases, and were randomly divided into a treatment group (47 cases) and a control group (35 cases). There was no significant difference between the two groups in age, sex, course of disease and extent of disease (P>0.05), see Table 3.

[0043] Table 3 The general situation of the patients in the treatment group and the control group

[0044]

[0045] Note: * for x 2 value, and the rest are t-v...

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Abstract

The invention relates to the technical field of medicines, in particular to clinical application of a compound enema consisting of resina draconis and common bletilla tuber to treating ulcerative colitis. Experiments of a DNCB (dinitrochlorobenzene) induced rat ulcerative colitis animal model and pathology observation, and the like find that the compound resina draconis enema can effectively improve rat diarrhea, hematochezia, weight reduction and colon tissue pathomorphology change and regulate phlogistic or phlogistic-inhibiting immunological factors, and facilitates to inflammation elimination and tissue recovery. 83 chronic nonspecific ulcerative colitis (UC) patients are treated by adopting the compound enema, which finds that the compound resina draconis enema can improve various hemarheology indexes of blood plasma viscosity, hematocrit, fibrinogen, and the like of the UC patient, and shows that the compound resina draconis enema has satisfied treatment effect on the UC, does not contain hormone and sulfanilamides, has no remarkable bad effects and is worthy of being clinically popularized and applied.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new application of a compound recipe composed of dragon's blood jellyfish and bletilla striata for preparing an enema medicine for treating ulcerative colitis. technical background [0002] Ulcerative colitis is a chronic, inflammatory and ulcerative disease that occurs in the colonic mucosa and is most typically characterized by bloody diarrhea. The etiology of ulcerative colitis is unknown, but there is evidence that genetic predisposition leads to an unregulated intestinal immune response to the environment, diet, or infectious agents. However, the eliciting antigen has not been identified. At present, there is still no effective radical cure at home and abroad, and comprehensive medical treatment is mainly used to control acute attacks, reduce recurrence, and prevent complications. Sulfasalazine (SASP) preparations can be used, 3 to 4 g per day, orally in divided doses; ...

Claims

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Application Information

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IPC IPC(8): A61P1/04A61K36/898
Inventor 王雪明李楠张林王艳梅翟俊山
Owner 王雪明
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