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Medicament for treating tristimania and preparation method thereof

A technology for depression and medicine is applied in the field of Hypericum perforatum extract for treating depression and its preparation field, and can solve the problems of low affinity, large side effects, influence on popularization and use, and the like

Active Publication Date: 2011-02-09
BEIJING WBL PEKING UNIV BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

① Drugs, because of many side effects and high toxicity, have been eliminated
In order to reduce side effects and reduce toxicity, some non-tricyclic antidepressants appeared in the 1970s, such as maprotiline, etc., but the side effects have not been completely overcome
③ Drugs, whose pharmacological feature is to specifically block the reuptake of serotonin, have a very low affinity for other neurotransmitter receptors in the brain, and have less toxic side effects than tricyclic drugs, but still have certain side effects
In a word, existing medicines all have some disadvantages: large side effects, high incidence rate, single mechanism of action, high price, easy recurrence, etc., which have seriously affected their popularization and use.
Existing products cannot meet the demand, therefore, the development of new, high-efficiency, broad-spectrum, low-toxic antidepressants has become one of the research and development directions of pharmaceutical companies in various countries

Method used

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  • Medicament for treating tristimania and preparation method thereof
  • Medicament for treating tristimania and preparation method thereof
  • Medicament for treating tristimania and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0153] Take Hypericum perforatum medicinal material 100kg and cut it into 2-3cm sections, and reflux extraction with 55% ethanol for 3 times: add 10 times the weight of solvent for the first time, extract after soaking for 8 hours, and reflux for 2 hours; add 6 weight for the second time double the solvent, reflux for 1 hour; add 6 times the weight of solvent for the third time, reflux for 1 hour, combine the three extracts and concentrate, recover ethanol, concentrate to a relative density of 1.004 at 30°C; add water and ethanol to dilute to 5 times the weight of the medicinal material, And adjusted to alcohol content of 15%, mixed, centrifuged; supernatant processed D-101 type macroporous adsorption resin column, stop loading after resin adsorption saturation; water elution, eluent volume is 5 times the volume of the column, discard the washing solution; then elute with 70% ethanol, collect the eluate, reclaim the ethanol, and concentrate the eluate to a relative density of 1...

Embodiment 2

[0157] 100 kg of Hypericum perforatum medicinal material is cut into small sections of 2-3 cm, extracted 3 times with 55% ethanol under reflux: first time add 10 times of solvent by weight, soak for 8 hours and then extract, reflux for 2 hours; second time add 6 times of weight Solvent, reflux for 1 hour; add 6 times the weight of solvent for the third time, reflux for 1 hour, concentrate the extract in stages, combine the three concentrates until the volume of the concentrate is 305L, and the relative density is 1.006 (30°C); add water and ethanol to dilute to the medicinal material 5 times the weight, and adjust to 15% alcohol content, mix well, and centrifuge; the supernatant is passed through the D-101 macroporous adsorption resin column that has been treated, and the sample loading is stopped after the resin is saturated; eluted with water, The volume of the eluent is 3 times the volume of the column, discard the water washing solution; then elute with 70% ethanol, collect...

Embodiment 3

[0161] 100 kg of Hypericum perforatum medicinal material is cut into 2-3cm segments, and refluxed extraction with 70% ethanol twice: add 12 times of solvent by weight for the first time to extract directly, and the reflux time is 2 hours; add 8 times of solvent by weight for the second time, and reflux for 1 Hours; the extract was concentrated in stages, and the two concentrated solutions were combined to a relative density of 1.021 (30°C); diluted with water and ethanol to 4.5 times the weight of the medicinal material, and adjusted to an alcohol content of 10%, mixed and centrifuged; the supernatant AB-8 type macroporous adsorption resin column that has been treated with liquid, stop loading the sample after the resin is saturated; elute with water, the volume of the eluent is 3 times the volume of the column, discard the washing liquid; then wash with 70% ethanol Remove, collect the eluent, recover ethanol, and concentrate to a relative density of 1.036 (30°C), spray-dry to ...

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Abstract

The invention discloses a medicament for treating tristimania and a preparation method thereof. The method comprises the following steps of: cutting a medicinal material, namely hypericum perforatum, performing refluxing extraction on the cut hypericum perforatum for three times by using 30 to 80 percent ethanol or 30 to 100 percent methanol, reclaiming a solvent, and concentrating; adding water and ethanol into the extract to dilute the extract until the weight of the extract is 3 to 7 times that of the medicinal material, adjusting until the alcohol content is 0 to 20 percent, uniformly mixing and centrifuging; making the supernatant pass through a treated macroporous adsorption resin column, and stopping sampling after resin adsorption is saturated; eluting with water until the eluate is clear and removing the washing liquor; eluting with 50 to 90 percent ethanol, collecting the eluate, reclaiming the ethanol, concentrating the product, and performing spray drying to obtain a hypericum perforatum extract; and adding conventional auxiliary materials into the hypericum perforatum extract and preparing clinically acceptable formulations, such as tablets, capsules, pills, particlesand the like by the conventional process.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a hypericum perforatum extract for treating depression and a preparation method thereof. Background technique [0002] Depression is a human emotional disease, which is chronic and recurrent, with diverse symptoms, such as depression, appetite and sleep disorders, world-weariness and suicidal tendencies. As people's pace of life accelerates, social competition intensifies, and population aging accelerates, depression has become an important disease that endangers public health. According to WHO statistics, patients with depression in the world account for 3% of the total population. The incidence of depression in my country has grown from 3.6‰ in the 1970s to 7.6‰ today, and about 30-70% are misdiagnosed as neurasthenia. In big cities such as Beijing and Shanghai, the incidence rate is as high as 3.43%, and the incidence rate is increasing year by year. People with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61P25/24A61K36/185
Inventor 段震文郭树仁樊利青
Owner BEIJING WBL PEKING UNIV BIOTECH
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