Medicament for treating tristimania and preparation method thereof
A technology for depression and medicine is applied in the field of Hypericum perforatum extract for treating depression and its preparation field, and can solve the problems of low affinity, large side effects, influence on popularization and use, and the like
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Embodiment 1
[0153] Take Hypericum perforatum medicinal material 100kg and cut it into 2-3cm sections, and reflux extraction with 55% ethanol for 3 times: add 10 times the weight of solvent for the first time, extract after soaking for 8 hours, and reflux for 2 hours; add 6 weight for the second time double the solvent, reflux for 1 hour; add 6 times the weight of solvent for the third time, reflux for 1 hour, combine the three extracts and concentrate, recover ethanol, concentrate to a relative density of 1.004 at 30°C; add water and ethanol to dilute to 5 times the weight of the medicinal material, And adjusted to alcohol content of 15%, mixed, centrifuged; supernatant processed D-101 type macroporous adsorption resin column, stop loading after resin adsorption saturation; water elution, eluent volume is 5 times the volume of the column, discard the washing solution; then elute with 70% ethanol, collect the eluate, reclaim the ethanol, and concentrate the eluate to a relative density of 1...
Embodiment 2
[0157] 100 kg of Hypericum perforatum medicinal material is cut into small sections of 2-3 cm, extracted 3 times with 55% ethanol under reflux: first time add 10 times of solvent by weight, soak for 8 hours and then extract, reflux for 2 hours; second time add 6 times of weight Solvent, reflux for 1 hour; add 6 times the weight of solvent for the third time, reflux for 1 hour, concentrate the extract in stages, combine the three concentrates until the volume of the concentrate is 305L, and the relative density is 1.006 (30°C); add water and ethanol to dilute to the medicinal material 5 times the weight, and adjust to 15% alcohol content, mix well, and centrifuge; the supernatant is passed through the D-101 macroporous adsorption resin column that has been treated, and the sample loading is stopped after the resin is saturated; eluted with water, The volume of the eluent is 3 times the volume of the column, discard the water washing solution; then elute with 70% ethanol, collect...
Embodiment 3
[0161] 100 kg of Hypericum perforatum medicinal material is cut into 2-3cm segments, and refluxed extraction with 70% ethanol twice: add 12 times of solvent by weight for the first time to extract directly, and the reflux time is 2 hours; add 8 times of solvent by weight for the second time, and reflux for 1 Hours; the extract was concentrated in stages, and the two concentrated solutions were combined to a relative density of 1.021 (30°C); diluted with water and ethanol to 4.5 times the weight of the medicinal material, and adjusted to an alcohol content of 10%, mixed and centrifuged; the supernatant AB-8 type macroporous adsorption resin column that has been treated with liquid, stop loading the sample after the resin is saturated; elute with water, the volume of the eluent is 3 times the volume of the column, discard the washing liquid; then wash with 70% ethanol Remove, collect the eluent, recover ethanol, and concentrate to a relative density of 1.036 (30°C), spray-dry to ...
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