Ginkgo flavone capsule and preparation method thereof

Abstract

The invention discloses a ginkgo flavone capsule and a preparation method thereof. The capsule is characterized by comprising a ginkgo flavone extract and an auxiliary material, wherein the ginkgo flavone extract is a product extracted from ginkgo leaves by the method. The method comprises the following steps of: (1) pulverizing ginkgo leaves, adding water, heating and extracting; (2) cooling extract liquid in the step (1) below 15 DEG C for standing and filtering; (3) drying filter liquid in the step (2) and collecting a dried product; (4) dissolving the dried product by an ethanol solution, standing and concentrating supernatant to obtain concentrated liquid; and (5) dissolving the concentrated liquid by ethanol and adsorbing and purifying by macroporous resin; and washing by water till the color of effluent liquid is light and eluting by the ethanol solution to obtain the ginkgo flavone extract. The ginkgo flavone capsule basically does not contain fat-soluble lactone components and has the advantages of high adsorbing effect, fast effect taking and high bioavailability.

Description

technical field [0001] The invention relates to a ginkgo flavone capsule and a preparation method thereof. Background technique [0002] Ginkgo tree has magical vitality and is known as "living fossil" and "longevity king". my country is the main producing area of ​​ginkgo trees, accounting for about 70% of the world's total. Ginkgo biloba is the leaf of Ginkgo biloba plant of Ginkgo family. According to the analysis and determination, Ginkgo biloba contains more than 160 kinds of components, among which there are more than 30 effective flavonoids active substances, and the content of flavonoids and terpene lactones in Ginkgo biloba is relatively high. In addition, Ginkgo biloba also contains essential amino acids and beneficial trace elements. Different collection seasons have an impact on the content of flavonoids. In summer and autumn, the content of flavonoids in ginkgo leaves has little change, while the content of flavonoids in young leaves in spring is the highest....

AI Technical Summary

Problems solved by technology

The current pharmacokinetic studies of the total flavonoids of Ginkgo biloba have shown that due to the difference in the ester-water partition coefficient between ginkgo flavonoids and ginkgolides, the absorption and release rates of hydrophilic flavonoids and lipophilic lactones are not synchronized in the body, and the lactones Class ingredients can affect the absorption process of aglycones

[0007] Due to the current various preparations containing ginkgo flavonoids, limited by the ginkgo extraction process used, the ginkgo extracts used contain both ginkgo flavonoids and ginkgolides. Due to the influence of lactones on the absorption of flavonoids, ginkgo flavonoids Slow absorption and release in the body, and also prolong the onset time of ginkgo flavonoids