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Ginkgo flavone tablet and preparation method thereof

A technology of ginkgo flavonoid tablets and ginkgo flavonoids is applied in the directions of medical raw materials derived from Ginkgo biloba, pill delivery, metabolic diseases, etc., which can solve the problem of the asynchronous absorption and in vivo release speed of hydrophilic flavonoids and lipophilic lactones, and the absorption and loss of ginkgo flavonoids. Slow release in the body, prolong the onset time of ginkgo flavonoids, etc., to achieve the effects of fast onset, fast absorption and in vivo release, and low tablet cost

Active Publication Date: 2011-04-06
陕西利君现代中药有限公司
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Problems solved by technology

The current pharmacokinetic studies of the total flavonoids of Ginkgo biloba have shown that due to the difference in the ester-water partition coefficient between ginkgo flavonoids and ginkgolides, the absorption and release rates of hydrophilic flavonoids and lipophilic lactones are not synchronized in the body, and the lactones Class ingredients can affect the absorption process of aglycones
[0007] Due to the current various preparations containing ginkgo flavonoids, limited by the ginkgo extraction process used, the ginkgo extracts used contain both ginkgo flavonoids and ginkgolides. Due to the influence of lactones on the absorption of flavonoids, ginkgo flavonoids Slow absorption and release in the body, and also prolong the onset time of ginkgo flavonoids

Method used

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Embodiment Construction

[0028] The present invention will be described in further detail below through specific examples to help understand the content of the present utility model.

[0029] Ginkgo flavonoid tablet prescription:

[0030] Ginkgo Flavonoid Extract 250.0g

[0031] Pregelatinized starch 85-105g

[0032] Hypromellose 1.2-1.5g

[0033] Magnesium stearate 1.5-1.9g

[0034] Silica 25-40 grams

[0035]

[0036] Makes 1000 pieces

[0037] The preparation process is as follows:

[0038] 1. Extraction of ginkgo flavonoids:

[0039] (1) Take 100kg of ginkgo leaves and coarsely crush them to 8 meshes, put them in a dynamic extraction tank, add ten times the amount of purified water and heat to 50±5°C, perform dynamic extraction three times, and combine the extracts;

[0040] (2) Cool the extract to below 15°C, let it stand for 12 hours, filter the extract, and separate impurities and the like;

[0041] (3) Then the filtrate is spray-dried, and the...

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Abstract

The invention discloses a ginkgo flavone tablet comprising a ginkgo flavone extract and an assistant, wherein the ginkgo flavone extract is a product obtained by extracting ginkgo leaves by using the method: crushing the ginkgo leaves, adding water, heating and extracting; cooling an extraction solution in the step (1) to below 15 DEG C and standing and filtering; drying filtrate in the step (2) and collecting a dried substance; dissolving the dried substance with an ethanol solution and standing; condensing supernate to obtain a concentrated solution; dissolving the concentrated solution with ethanol and adsorbing and purifying with macroporous resin; and washing until the color of effluent fluid becomes light and eluting with the ethanol solution to obtain the ginkgo flavone extract. The tablet can be quickly absorbed and released in body and has high bioavailability.

Description

technical field [0001] The invention relates to a ginkgo flavone tablet and a preparation method thereof. Background technique [0002] Ginkgo tree has magical vitality and is known as "living fossil" and "longevity king". my country is the main producing area of ​​ginkgo trees, accounting for about 70% of the world's total. Ginkgo biloba is the leaf of Ginkgo biloba plant of Ginkgo family. According to analysis and determination, ginkgo leaves contain more than 160 kinds of ingredients, among which there are more than 30 kinds of flavonoid active substances with medicinal effects, and the content of flavonoids and terpene lactones in ginkgo leaves is relatively high. In addition, Ginkgo biloba also contains essential amino acids and beneficial trace elements. Different collection seasons have an impact on the content of flavonoids. In summer and autumn, the content of flavonoids in ginkgo leaves has little change, while the content of flavonoids in young leaves in spring...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K9/20A61P3/06A61P7/02A61P9/10A61K127/00
Inventor 江振鸣
Owner 陕西利君现代中药有限公司
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