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Application of panaxadiol saponin in preparing medicines combined with glucocorticoid receptor

A technology of ginseng diol saponins and glucocorticoids, which is applied in the field of medicine and can solve problems such as the death of critically ill patients

Inactive Publication Date: 2011-04-13
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, acute stress bleeding caused by glucocorticoids can cause death in critically ill patients and become an invisible killer

Method used

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  • Application of panaxadiol saponin in preparing medicines combined with glucocorticoid receptor
  • Application of panaxadiol saponin in preparing medicines combined with glucocorticoid receptor
  • Application of panaxadiol saponin in preparing medicines combined with glucocorticoid receptor

Examples

Experimental program
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Effect test

experiment example

[0014] Experimental example: the effect of different doses of PDS on the transcriptional activity of glucocorticoid receptor.

[0015] The reporter gene (GRE-Luciferase) activated by the glucocorticoid receptor response element (GRE-Luciferase) and the glucocorticoid receptor (Glucocorticoid Receptor) were co-transfected into 293 cells. Observe the effect of adding dexamethasone on the transcriptional activity of glucocorticoid receptor; then replace dexamethasone with PDS, observe whether different doses of PDS have an effect on the transcriptional activity of glucocorticoid receptor, and conduct a comprehensive evaluation of whether it is dose-dependent .

[0016] Materials and Methods:

[0017] 1.293 cell line, purchased from ATCC, USA. Place in RPMI 1640 (GIBCO BRL Company) culture medium containing 5% (V / V) calf serum and antibiotics, at 37°C, 5% CO 2 cultured in an incubator.

[0018] 2. The drug ginseng stem and leaf diol group saponin (PDS) is provided by the Natur...

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Abstract

The invention relates to application of panaxadiol saponin (PDS) in preparing medicines combined with a glucocorticoid receptor, and belongs to the field of medicines. The panaxadiol saponin is applied to preparing the medicines combined with the glucocorticoid receptor, and the panaxadiol saponin and cis-platinum are jointly applied to resisting tumors; and in the study that the PDS and the cis-platinum are combined to resist prostatic cancer transplanting tumors, the PDS has antiallergic and attenuation effects like Dexa, but the PDS group has the survival time, spleen index, fur brightness degree and the like superior to those of the Dexa group. Mice in a Dexa and cis-platinum combined administration group all die before the 13th days in the course of treatment particularly. Therefore, the PDS has the same molecular mechanism as the Dexa, and has important significance for developing new medicines in which the PDS replaces the Dexa.

Description

technical field [0001] The invention belongs to the field of medicine. Background technique [0002] The actions and side effects of glucocorticoids such as Dexamethasone (Dexa) are recorded in pharmacology textbooks: (1) The pharmacological effects are that Dexa has anti-inflammatory, anti-endotoxin, immune suppression, anti-shock and enhanced stress responses, etc. Because of its pharmacological effects, it is widely used in various departments to treat various diseases, such as autoimmune diseases, allergies, inflammation, asthma, dermatology, eye diseases, etc. In recent years, the clinical dosage of dexamethasone has increased year by year, and my country has become the largest market for dexamethasone in the world. (2) The summary of side effects is as follows: ①Long-term or large-scale use of Dexa may cause iatrogenic Cushing’s syndrome, facial appearance and posture, hypokalemia syndrome, and bleeding tendency; ②Poor wound healing and osteoporosis may cause femoral ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K33/24A61P35/00
Inventor 赵雪俭张灵程金科赵丹李扬刘艳波赵丽娟孟艳李璐梁作文
Owner JILIN UNIV
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