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Nutmeg extract with antitumor effect and medicinal preparation thereof

A technology for anti-tumor effects and pharmaceutical preparations, applied in anti-tumor drugs, medical preparations containing active ingredients, drug combinations, etc.

Inactive Publication Date: 2011-07-06
林秀坤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Before the present invention, there is no report that the nutmeg extract is used as a raw material to prepare pharmaceutical dosage forms and be used for the prevention and treatment of tumor diseases

Method used

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  • Nutmeg extract with antitumor effect and medicinal preparation thereof
  • Nutmeg extract with antitumor effect and medicinal preparation thereof
  • Nutmeg extract with antitumor effect and medicinal preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, the preparation of nutmeg extract

[0049] Take 500g of nutmeg (Qingdao Beijing Tongrentang Pharmacy, item number 100715), mix it with 95% ethanol (ethanol: water = 95:5, volume ratio) at a ratio of 1:3 (nutmeg: 95% ethanol) , reflux at 60°C for 3 hours, filter with suction, and collect the extract; add the same amount of 95% ethanol as the first time to the filter residue, reflux and extract at 60°C for 3 hours, collect the extract, and combine it with the first time; add the filter residue and the second An equal amount of 95% ethanol was extracted once again at 60°C for 3 hours, suction filtered, the third reflux extract was collected, combined with the previous two reflux extracts, the obtained extract was concentrated under reduced pressure and vacuum dried ( removal of ethanol and water) to constant weight to obtain 4.6 g of nutmeg extract.

Embodiment 2

[0050] Example 2 Preparation of Nutmeg Extract Pharmaceutical Preparations

[0051] (1) Preparation of tablets

[0052] 100g of nutmeg extract, 100g of medicinal starch, mixed evenly, granulated with appropriate amount of ethanol as a binder, dried, granulated by a granulator, compressed into tablets, 0.30g per tablet, orally, 1-2 tablets each time, twice daily.

[0053] (2) Preparation of capsules

[0054] Nutmeg extract 100g, medicinal starch 100g, mix evenly, granulate with appropriate amount of ethanol as a binder, dry, pass through a 120 mesh sieve for granulation, pack 0# capsules, 0.300g per capsule, take 1-2 capsules each time , twice a day.

[0055] (3) Preparation of dropping pills

[0056] polyethylene glycol 4000 1200g, melted on a water bath, added 750g of nutmeg extract raw material, stirred evenly, poured into the insulation tube, adjusted the constant temperature device, so that the liquid medicine was dropped into the cooled liquid paraffin at 80-90°C (t...

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Abstract

The invention discloses novel medicinal application of a nutmeg extract in resisting tumor, a method for preparing the nutmeg extract by taking nutmeg as a raw material and extracting by using water and / or an organic solvent, and a clinically acceptable medicinal preparation which is prepared into formulations such as tablets, capsules, pills, injections and the like by taking the nutmeg extract as a raw material. The medicinal preparation contains 1 to 99 weight percent of nutmeg extract and 99 to 1 weight percent of pharmaceutical excipients (comprising other medicines for compatibility). The nutmeg extract and the medicinal preparation thereof have good antitumor effect due to apparent inhibitory activity for five tumor cells of in-vitro human ovarian cancer, human cervical carcinoma, human liver cancer, human colorectal carcinoma and human breast cancer, and remarkable antitumor activity on nude mice transplanted tumor of the five tumor cells. In addition, a main active ingredient of the medicinal preparation is a Chinese medicinal extract, so the medicinal preparation has the advantage of small toxic or side effect compared with chemotherapeutic medicines.

Description

technical field [0001] The invention relates to the application of nutmeg extract in the preparation of antitumor drugs and its pharmaceutical preparations, belonging to the field of traditional Chinese medicine. Background technique [0002] Nutmeg is the dried and mature seed kernel of Myristica fragrans Houtt., which can cure diarrhea, cold dysentery, cold abdominal pain, vomiting, etc. It can be used externally as a parasite repellent, and can treat rheumatic pain, etc. Nutmeg contains volatile oil, fatty acid, starch, protein and a small amount of sucrose, pentosan, pigment, etc. Among them, volatile oil has strong pharmacological activity, and has analgesic, antidiarrheal, antiviral and other effects. [0003] Malignant tumors are common and frequently-occurring diseases that seriously threaten human health. The development of anticancer drugs has become a major topic of new drug research in this century. At present, looking for antitumor drugs with high efficiency an...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P35/00A61K131/00
Inventor 林秀坤刘海洲廖德忠
Owner 林秀坤
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