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Application of affine cudweed extractive in preparing medicaments for preventing and curing chronic infectious arthritis

A rheumatoid, sagebrush technology, applied to the application of sagebrush extract in the preparation of drugs for the prevention and treatment of rheumatoid arthritis, the application field of plant extracts, to achieve the effect of great practical application value and simple preparation method

Inactive Publication Date: 2011-07-27
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no report about the use of sage extracts in the treatment of rheumatoid arthritis

Method used

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  • Application of affine cudweed extractive in preparing medicaments for preventing and curing chronic infectious arthritis
  • Application of affine cudweed extractive in preparing medicaments for preventing and curing chronic infectious arthritis
  • Application of affine cudweed extractive in preparing medicaments for preventing and curing chronic infectious arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 sage extract

[0030] The dried whole herb of S. chinensis medicinal material (purchased from Bozhou Medicinal Materials Market, Anhui, China), after crushing 5 kg of S. sagerae herb, was extracted with 80% ethanol (70° C.) for 3 times, 40 L each time, and the extraction time was 3 times. After 2 hours, after combining the extracts, concentrate them under reduced pressure at 60°C to dryness, and then put them into an oven at 60°C and further dry them to constant weight to obtain 625.0g of S. sagebrush extract of the present invention, with a yield of 12.5% ​​in terms of crude drug amount. %.

Embodiment 2

[0031] The preparation of embodiment 2 sage extract

[0032] After crushing the whole 5kg of Sage sage, heat extraction (80°C) with 50% ethanol for 3 times, 40L each time, and the extraction time is 2 hours each time, after combining the extracts, concentrate to dryness at 60°C under reduced pressure, and then Put it into an oven at 60° C. and further dry to constant weight to obtain 780.3 g of the sage extract of the present invention, and the recall rate according to the crude drug amount is 15.6%.

Embodiment 3

[0033] The preparation of embodiment 3 sage extract

[0034] After crushing 5kg of the whole sage grass, heat extraction (90°C) with 20% ethanol for 3 times, 40L each time, and the extraction time is 2 hours each time, after combining the extracts, concentrate to dryness at 60°C under reduced pressure, and then Put it into an oven at 60° C. and further dry to constant weight to obtain 665.8 g of the sage extract of the present invention, and the recall rate according to the crude drug amount is 13.3%.

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Abstract

The invention discloses application of an affine cudweed extractive in preparing medicaments for preventing and curing chronic infectious arthritis. By experiments, the affine cudweed extractive has the applications that (1) an in-vitro anticomplement activation classic approach cell hemolysis test confirms that the affine cudweed extractive has a stronger anticomplement activity and can be used for autoimmunity inflammation diseases caused by abnormal anticomplement activation; (2) in a model experiment that foot sole acute inflammation of a mouse is caused by carrageenin, a result shows that the affine cudweed extractive has an obvious action on inhibiting the foot tumescence of the mouse; and (3) in an experiment that the affine cudweed extractive has the action on preventing and curing II type collagen chronic infectious arthritis of a rat, a result indicates that the affine cudweed extractive has an extremely obvious action on inhibiting the foot sole tumescence of a rat model with chronic infectious arthritis induced by II type collagen. Therefore, the invention provides a new approach for clinically curing the chronic infectious arthritis, and the preparation method of the affine cudweed extractive is simple and convenient and has a larger actual application value.

Description

technical field [0001] The invention relates to a plant extract, in particular to the application of the plant extract, in particular to the application of the sage extract in the preparation of drugs for preventing and treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is an autoimmune disease mainly characterized by chronic inflammation of the synovial membrane of the joints, which can cause joint swelling and pain, and then lead to cartilage destruction, narrowing of the joint space, late joint deformity, and eventually various degrees of disability. The prevalence rate in China is 0.3% to 0.4%, 70% of patients will become disabled after 3 years, and the average life expectancy will be shortened by 10 to 15 years, which greatly affects people's quality of life. For this reason, it is of great significance to research and develop effective anti-rheumatoid arthritis drugs. [0003] In addition, the complement system is one of the important im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P19/02A61P29/00
Inventor 孙连娜席忠新李霞赵贵钧王燕陈万生
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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