New application of sodium ferrous chlorophyll to promotion of erythropoiesis

A kind of technology of sodium iron chlorophyllin and erythropoietin, which is applied in the field of medicine

Inactive Publication Date: 2011-08-03
武汉联合药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in the prior art, sodium iron chlorophyllin has been simply used as an iron supplement, and it has not been found to have other effects

Method used

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  • New application of sodium ferrous chlorophyll to promotion of erythropoiesis
  • New application of sodium ferrous chlorophyll to promotion of erythropoiesis
  • New application of sodium ferrous chlorophyll to promotion of erythropoiesis

Examples

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Effect test

Embodiment 1

[0011] Example 1: Application of sodium iron chlorophyllin in the treatment of renal anemia caused by renal failure

[0012] Renal anemia is one of the important complications of chronic renal failure. Patients with renal failure are often accompanied by iron deficiency during hemodialysis. The conventional treatment is mainly injection of erythropoietin (EPO), supplemented by iron supplementation. Studies have shown that silkworm excrement Shengxuening Tablets (the main active ingredient is sodium iron chlorophyllin) can efficiently supplement biological iron, can promote the absorption of free iron in the body and food, and can also stimulate bone marrow cell proliferation. The purpose of this study is to compare the effect of Shengxuening Tablets and Ferrous Succinate Tablets combined with EPO in the treatment of renal anemia in maintenance hemodialysis patients with iron deficiency, and to observe the replacement effect of iron sodium chlorophyllin on EPO.

[0013] 1. Rese...

Embodiment 2

[0041] Example 2: Application of sodium iron chlorophyllin in the treatment of renal anemia in patients with chronic kidney disease stage 3-4

[0042] Renal anemia is one of the important complications of chronic kidney disease (CKD). Renal anemia in patients with CKD stage 3-4 is often accompanied by iron deficiency. The conventional treatment is mainly to inject erythropoietin (EPO) to supplement iron. The purpose of this study is to compare iron sodium chlorophyllin and ferrous succinate tablets, and if necessary, combine them with EPO to treat renal anemia in patients with CKD stage 3-4, and observe the substitution effect of iron sodium chlorophyllin on EPO.

[0043] 1. Research Methods

[0044] 1. Case selection This study was completed collaboratively by seven hospitals in Shanghai. Patients with CKD stage 3-4 renal anemia [eGFR 15-59ml / (min·1.73m 2 ), GFR=186×serum creatinine-1.154×age-0.203×0.742 (female)×1.233 (Chinese)], were randomly divided into test group (Shen...

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Abstract

The invention discloses new application of sodium ferrous chlorophyll to the promotion of erythropoiesis, and belongs to the field of medicines. Sodium ferrous chlorophyll has the effect of erythropoietin, and can be prepared into medicaments for treating anemia such as 'anemia of chronic disease' or 'renal anemia' which are caused by hyposecretion in erythropoietin.

Description

technical field [0001] The invention provides a new application of sodium iron chlorophyllin in the field of blood disease treatment, especially the effect of promoting red blood cell production and treating anemia of chronic disease or renal anemia, which belongs to the field of medicine. Background technique [0002] Erythropoietin (also known as: erythropoietin, Erythropoietin, EPO), is a glycoprotein cytokine with a molecular mass of 46kDa produced in the kidney and liver of mammals. It is a hormone-like substance that can stimulate Proliferation, hemoglobinization, and maturation of immature erythrocytes. When there is a lack of EPO in the body due to various reasons, especially when the secretion of EPO by the kidneys is insufficient, the number of red blood cells will decrease, which will cause anemia. At present, the most common anemias with EPO deficiency as the main direct cause include "anemia of chronic disease" and "renal anemia". [0003] The so-called "anemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/409A61P7/06A61P13/12
Inventor 刘朝胜
Owner 武汉联合药业有限责任公司
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