Decomposable biocompatible hydrogels and system and method for using same

A biocompatible, hydrogel technology for use in the field of biocompatible polymerizable hydrogels

Inactive Publication Date: 2011-08-24
恩伟绅技术公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Broadly speaking, several irrigation/drug/material approaches have bee

Method used

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Examples

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Embodiment Construction

[0061] Non-limiting examples of biocompatible and functional monomers and polymers suitable for use in the practice of the invention include N-vinylamides, such as N-methylvinylacetamide. These structures provide useful complements to structurally isomeric substituted acrylamides, such as N,N-dimethylacrylamide. Similarly, N-acryloylmorpholine and N-hydroxyethylacrylamide provide examples of less widely used members of the acrylamide family, which in turn effectively complement the range of hydrogel polymer precursors. Other examples are ionic and zwitterionic monomers, 2-acrylamido-2-methylpropanesulfonic acid (AMPS) and its sodium salt (sodium 2-acrylamido-2-methylpropanesulfonate (NaAMPS) ). Other sulfonate monomers provide valuable structural additions. These include sulfopropyl acrylate (SPA), sulfopropyl itaconate (SPI) and sulfopropyl methacrylate (SPM). Zwitterionic monomer, N,N-Dimethyl-N-(2-acryloylethyl)-N-(3-sulfopropyl)betaine ammonium salt (SPDA) [Raschig, GMB...

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Abstract

Biocompatible, triggerable degradation, polymerizable hydrogels, uses and delivery devices are disclosed. These hydrogels are at least substantially water soluble macromers, having a variety of uses especially for ocular therapy. The macromers include at least one water soluble region, at least one region which is degradable via a triggering event, usually by hydrolysis, and at least two free radical-polymerizable regions. The regions can, in some embodiments, be both water soluble and trigger able degradable. The macromers are polymerized by exposure of the polymerizable regions to free radicals generated by photosensitive chemicals and dyes. An advantage of these polymer hydrogels is that they can be polymerized rapidly in an aqueous surrounding. Precisely conforming, semi-permeable, biodegradable films or membranes can thus be formed on tissue in situ to serve as biodegradable barriers, as carriers for living cells or other biologically active materials, and as surgical adhesives for the eye.

Description

technical field [0001] The present invention relates to biocompatible hydrogels, and more particularly to biocompatible polymerizable hydrogels and to systems and methods of using the same. The invention has particular utility in relation to biocompatible hydrogels and their use as biodegradable barriers, for example for the treatment of the eye, and will be described in connection with this utility, although other utilities are contemplated. Background technique [0002] Existing polymeric biomaterials, including ophthalmic materials, while often suited for specific functions, are subject to limitations. Existing ophthalmic biomaterials such as intraocular lenses, artificial corneas and contact lenses show satisfactory ocular biocompatibility, but they must be removable for long-term use. As with many existing biodegradable products, they degrade relatively slowly over time and can be affected by uncontrolled environmental factors. Therefore, a polymer that degrades rapid...

Claims

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Application Information

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IPC IPC(8): A61K9/10
CPCA61K9/0048A61K9/06A61P27/02A61P29/00A61P31/00A61P35/00
Inventor 路易斯·布雷特杰弗里·卡茨马克·巴尼斯特
Owner 恩伟绅技术公司
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