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Laser system for blood cell analysis, flow cell analysis and body fluid analysis

A technology of flow cytometry and blood cell analysis, applied in the field of laser systems, can solve problems such as limited cell information, accuracy to be improved, missed or wrong detection, etc., to reduce interference, improve detection accuracy, and reduce false detection Effect

Inactive Publication Date: 2011-09-07
SHENZHEN MAXCOM ELECTRONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the laser system with a single light source in the current cell analyzer can only use one beam of laser light to irradiate the cell sample from one direction to obtain a set of analysis results, and the obtained internal information of the cell is limited; the existence of the cell membrane will affect the scattering of the nucleus, and the This effect cannot be eliminated in the current laser system; in addition, because of the irregularity of the number and shape of the nucleus in the white blood cell, the analysis of the cell by the cell analyzer of the single-energy system may be missed or wrongly detected. , the accuracy of the detection results of cell counting and classification needs to be improved

Method used

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  • Laser system for blood cell analysis, flow cell analysis and body fluid analysis
  • Laser system for blood cell analysis, flow cell analysis and body fluid analysis
  • Laser system for blood cell analysis, flow cell analysis and body fluid analysis

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Example 1. Dual energy laser system.

[0053] Such as figure 1 As shown, the present invention provides a laser system for blood cell analysis, flow cytometry analysis, and body fluid analysis, including: a first laser source 1; a second laser source 2; a first focusing device, a first focusing The device includes a first collimating mirror 32, a first focusing lens 31; a second light collecting device, and the second light collecting device includes a second collimating mirror 42, a second focusing lens 41, and a first dichroic film 8; Receiving device, forward receiving device comprises forward concentrating device and the first forward receiving device 62, forward shading sheet 63, the second dichroic sheet 64, the second forward receiving device 65, forward concentrating device is Forward focus lens 61; Side receiving device, side receiving device comprises side light concentrating device and first side receiving device 72, the 3rd dichroic sheet 74, the second sid...

Embodiment 2

[0061] Example 2. Dual energy laser system.

[0062] Such as figure 2 As shown, the present invention provides a laser system for blood cell analysis, flow cytometry analysis, and body fluid analysis, including: a first laser source 1; a second laser source 2; a first focusing device, a first focusing The device comprises the first collimating mirror 32, the first focusing lens 31, the full reflection sheet 9; the second light collecting device, the second light collecting device comprises the second collimating mirror 42, the second focusing lens 41, the first dichroic Sheet 8; Forward receiving device, forward receiving device comprises forward concentrating device and first forward receiving device 62, forward shading sheet 63, second dichroic sheet 64, second forward receiving device 65, front The light concentrating device is a forward focusing lens 61; the side receiving device, the side receiving device comprises a side light concentrating device and a first side rece...

Embodiment 3

[0065] Example 3. Dual energy laser system.

[0066] Such as image 3 As shown, the present invention provides a laser system for blood cell analysis, flow cytometry analysis, and body fluid analysis, including: a first laser source 1; a second laser source 2; a first focusing device, a first focusing The device comprises a first collimating mirror 32, a first focusing lens 31; a second light collecting device, the second light collecting device includes a second collimating mirror 42, and a second focusing lens 41; forward receiving device, the forward receiving device includes Forward concentrating device and first forward receiving device 62, forward shading sheet 63, second dichroic sheet 64, second forward receiving device 65, forward concentrating device is forward focusing lens 61; Receiving device, side receiving device comprises side light concentrating device and first side receiving device 72, side light shielding sheet 73, the third dichroic sheet 74, the second s...

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Abstract

The invention relates to a laser system for blood cell analysis, flow cell analysis and body fluid analysis, which comprises a first laser source, a second laser source, a first condensation device, a second condensation device and a front receiving device and a lateral receiving device, wherein the first laser source transmits laser with first wavelength; the second laser source transmits laser with second wavelength; the first condensation device makes the laser transmitted by the first laser source condense and enter a sample room; the second condensation device makes the laser transmitted by the second laser source condense and enter the sample room; and the front receiving device and the lateral receiving device are used for collecting emergent light signals of the sample room. The laser system can reduce the interference of cell membranes on cell nucleus scattering in the process of detecting a cell sample, acquire more information of a detected object, reduce error detection and omission detection of the detected objects, and improve the detection accuracy of a detector.

Description

technical field [0001] The invention relates to a laser system, in particular to a laser system for blood cell analysis, flow cytometry analysis and body fluid analysis. Background technique [0002] The existing cell analysis methods mainly include impedance method, laser method, laser fluorescence method and radio frequency method. Among them, the impedance method is widely used because of its simple principle, stability and low price. However, the impedance method can only obtain the cell volume, which is mainly used in the three classifications of red blood cells, platelets, and white blood cells. White blood cells are generally divided into five categories: lymphocytes, monocytes, neutrophils, eosinophils, and basophils. These cells cannot be classified simply by the resistance method. In the field of white blood cell classification, laser has become an important tool. Due to the structure, chemical composition, shape, and size of cells, the scattered light has diffe...

Claims

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Application Information

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IPC IPC(8): G01N15/10
Inventor 党福喜
Owner SHENZHEN MAXCOM ELECTRONICS
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