Usage of yeast in preparation of anticoccidial drugs
An anti-coccidiosis and yeast technology, applied in anti-infective drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as prevention and treatment of unseen parasitic diseases
Active Publication Date: 2013-02-06
JILIN UNIV
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Problems solved by technology
However, yeast has not been reported as an adjuvant for vaccines, nor has it been used in the prevention and treatment of parasitic diseases.
Method used
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Embodiment 1
[0075] Yeast can be inoculated in 300ml YPD medium. After the bacterial solution is saturated, the yeast cells are collected by centrifugation at 1000 × g at room temperature, and 200 μL of cell lysate is added to resuspend the yeast cells. The yeast is broken with acid-washed glass beads, and then Ultrasound was used to sonicate for 20 minutes, the protein concentration was measured, and a protein solution of 1 μg / μL was prepared, and stored at -20°C for later use. When used, it can be used as an adjuvant and mixed with the vaccine in equal amounts.
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The invention discloses an application of yeast in preparing anticoccidial drugs. Specifically, with an ability to improve the nonspecific immunity of organisms, yeast is applied to the parasitic disease field. By taking protein obtained from disrupted yeast cells as the adjuvant of coccidiosis vaccines, the immune protection effect of vaccines can be remarkably enhanced, so that yeast can be used for the prevention and treatment of coccidiosis.
Description
technical field [0001] The invention discloses the application of yeast in the preparation of anti-coccidiosis drugs, which can be used as an adjuvant for coccidiosis vaccines to prevent and treat coccidiosis, and belongs to the technical field of medical pharmacy. Background technique [0002] Coccidia is a single-celled parasitic protozoan, which widely parasitizes in the intestinal epithelial cells of poultry, and can cause severe diarrhea, intestinal bleeding, and even death of the host, resulting in serious economic losses. Eimeria tenella is a more serious disease among coccidia, and it has always been paid attention to in chicken production. However, due to the emergence of drug resistance, some anticoccidial drugs cannot produce a good effect on the prevention and treatment of coccidiosis, and problems such as drug residues also affect the progress of anticoccidial drug research. The study of immune protective vaccine is an ideal means to prevent coccidiosis, but th...
Claims
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Login to View More IPC IPC(8): A61K39/39A61K39/012A61P33/02
Inventor 张西臣郑君李建华宫鹏涛张楠杨举张国才李赫陈玉江任文陟李淑红
Owner JILIN UNIV