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Antibacterial composite medicine containing sulbenicillin sodium and clavulanic acid compound

A technology of sulfobenicillin sodium and clavulanate potassium, which is applied in the field of antibacterial combination drugs, can solve the problems of increasing the dosage, increasing the economic burden, and being difficult to achieve bactericidal effect, and reducing the dosage of the drug and reducing the economic burden. Effect

Inactive Publication Date: 2011-10-12
HUNAN ERKANG XIANGYAO PHARMA
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  • Abstract
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Problems solved by technology

However, with the widespread application, the resistance of bacteria to sulbenicillin sodium has increased, and it is difficult to achieve the previous bactericidal effect when the dosage is increased.
The use of large doses of sulbenicillin sodium not only increases the economic burden of patients, but also further enhances the resistance of bacteria

Method used

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  • Antibacterial composite medicine containing sulbenicillin sodium and clavulanic acid compound
  • Antibacterial composite medicine containing sulbenicillin sodium and clavulanic acid compound

Examples

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Effect test

Embodiment 1-6

[0015] The drugs and bacterial strains used in the following examples and comparative examples are all commercially available.

[0016] In each of the following examples and comparative examples, each material is mixed by weight ratio.

[0017] MIC refers to the minimum concentration of antibacterial combination drugs that can inhibit the growth of bacteria in the medium in vitro tests; MIC 50 (50% minimum inhibitory concentration), is the minimum inhibitory concentration of 50%, under the same experimental conditions, MIC 50 The smaller the value, the better the antibacterial effect of the drug, and the MIC unit is ug / g.

[0018] Embodiment 1-6 and comparative example 1-2 all operate and record MIC according to the experiment of measuring minimum inhibitory concentration of medicine (abbreviation MIC) in common microorganism test 50 Listed in Table 1.

[0019] Table 1 lists the comparative examples and the MICs of different antimicrobial drug combinations 50 ; The MIC of ...

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Abstract

The invention provides an antibacterial composite medicine containing sulbenicillin sodium and a clavulanic acid compound, a freeze-dried powder injection containing the antibacterial medicinal composition. The medicine consists of sulbenicillin sodium and a clavulanic acid compound, which are in a weight ratio of (2-7):1. Under the same antibacterial condition, the antibacterial composite medicine provided by the invention reduces medicine dose, economic load of patients and production cost.

Description

technical field [0001] The invention relates to an antibacterial combination drug, in particular to an antibacterial combination drug containing sulbenicillin sodium and its freeze-dried powder injection. Background technique [0002] In recent years, sulbenicillin sodium has been widely used as an antibiotic in clinic. However, with the wide application, the resistance of bacteria to sulbenicillin sodium has increased, and it is difficult to achieve the previous bactericidal effect by increasing the dosage. The use of large doses of sulbenicillin sodium not only increases the economic burden of patients, but also further enhances the drug resistance of bacteria. In order to address the increasing drug resistance, there is an urgent need to develop a new combination of antibacterial drugs. Contents of the invention [0003] The object of the present invention is to provide an antibacterial combination drug containing sulbenicillin sodium and clavulanic acid compounds. Th...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K31/424A61K9/19A61P31/04
Inventor 帅放文王向峰章家伟
Owner HUNAN ERKANG XIANGYAO PHARMA
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