Method for treating articular cartilage defect and magnetic focusing instrument used in method

A technology of articular cartilage and magnetic focusing, applied in treatment, magnetic therapy, electrotherapy, etc., can solve problems such as synovial hyperplasia, and achieve the effect of easy control, simple operation, and simple structure

Inactive Publication Date: 2012-01-04
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Problems solved by technology

However, because exogenous BMSCs cannot specifically gather in the cartilage defect area, they are easily diluted by joint fluid and attached to the synovial tissue, causing synovial hyperplasia, free body formation and other complications, which makes cell therapy urgently needed. One of the problems addressed is: optimal stem cell delivery strategy (i.e. spatially targeted transplantation)

Method used

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  • Method for treating articular cartilage defect and magnetic focusing instrument used in method
  • Method for treating articular cartilage defect and magnetic focusing instrument used in method

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Embodiment Construction

[0020] A kind of method for the treatment of articular cartilage defect of the present embodiment, comprises the following steps:

[0021] a, Prepopulated stem cells were labeled with superparamagnetic iron oxide (SPIO) to make them magnetic;

[0022] b, using a magnetic resonance scanner to scan the joint to determine the cartilage defect site, this embodiment uses a 1.5T MRI scanner for joint scanning;

[0023] c, The SPIO-labeled stem cells were injected into the joint cavity with cartilage defect; the SPIO-labeled stem cells were driven from different directions by external magnetic force, so that they could reach the articular cartilage defect accurately.

[0024] The invention utilizes the magnetic properties of the SPIO-labeled stem cells, so that the magnetic force in different directions interacts with the SPIO to control the transfer route of the stem cells, so that they can be accurately transplanted to the cartilage defect position to achieve the purpose of treatme...

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Abstract

The invention discloses a method for treating an articular cartilage defect and a magnetically marked cell targeted transplantation controlled magnetic focusing instrument special for the method. The characteristic that superparamagnetic iron oxide (SPIO) marked stem cells have magnetic property is utilized, and the transmission path of the stem cells is controlled under the action of magnetic forces in different directions and SPIO, so that the stem cells are accurately transplanted to a position with a cartilage cell defect, and the aim of treatment is fulfilled; meanwhile, after the special magnetic focusing instrument is adopted, the motion path of the SPIO marked stem cells can be conveniently and accurately controlled by controlling the power-on condition, current size (magnetic force size) and magnetic force direction of each magnetic coil, and interlink among the cells in the vertical direction can be promoted under the action of the magnetic forces and the SPIO, so that a bracket-free three-dimensional stem cell lamellar tissue engineering structure is constructed. The instrument has a simple structure and is convenient to control and easy and convenient to operate.

Description

technical field [0001] The invention relates to a treatment method for articular cartilage defect and a controllable magnetic focuser specially used in the method for targeted implantation of magnetically labeled cells. Background technique [0002] Articular cartilage defects are common in clinic, but there is no "gold standard" treatment path at present. The discovery of the pluripotency of bone marrow mesenchymal stem cells (BMSCs) has initiated the exploration of tissue regenerative medicine and provided new ideas for clinical medicine. Intra-articular injection of mesenchymal stem cells is currently one of the most minimally invasive treatment approaches. However, because exogenous BMSCs cannot specifically gather in the cartilage defect area, they are easily diluted by joint fluid and attached to the synovial tissue, causing synovial hyperplasia, free body formation and other complications, which makes cell therapy urgently needed. One of the problems addressed is: o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N2/04
Inventor 陈加荣杨柳冯勇王凤玲张一闫飞林肖
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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