Pharmaceutical composition and medicine for treating hepatic injury, and preparation method thereof

Abstract

The invention relates to a pharmaceutical composition and medicine for treating hepatic injury, and a preparation method thereof. The composition is prepared from the following active pharmaceutical ingredients in parts by weight: 5-10 parts of picrorhiza rhizome, 5-10 parts of safflower, 1-5 parts of Tibetan capillaris, 1-5 parts of sophora moorcroftiana seed and 1-5 parts of myrobalam. The extracts of the active pharmaceutical ingredients and pharmaceutically acceptable assistant ingredients can form a corresponding oral preparation. The pharmaceutical composition is used for treating chemical hepatic injury, pathological hepatic injury and hepatic injury caused by many other reasons, and can have an ideal effect.

Description

technical field

[0001] The invention relates to a pharmaceutical composition for treating liver damage, a corresponding medicine and a preparation method thereof. Background technique

[0002] The liver is an important metabolic and secretory organ of the human body. While it is powerful, it is also a fragile organ that can easily cause liver damage. The causes of liver injury mainly include violent liver injury, pathological liver injury, and chemical liver injury. Among them, violent liver injury usually manifests rapidly and is severe, while pathological liver injury and chemical liver injury are the most common. At present, both the overall environment and people's lifestyle are extremely unfavorable to the health of the liver. Factors that cause liver damage exist widely, which is an important reason for the rapid expansion of the number of people with liver damage. If staying up late and working too hard will cause relatively insufficient liver blood flow, affect th...

Examples

Embodiment 1

[0024] Take 600g of Huhuanglian, 450g of Tibetan Yinchen, 150g of Sophora japonica, and 300g of Myrobalan, crush them into coarse powder, add 70% ethanol to reflux and extract twice, add 10 times the amount for the first time, add 8 times the amount for the second time, and add 8 times the amount each time. Flow for 1 to 2 hours, filter, combine the filtrates, recover ethanol under reduced pressure, concentrate, and extract for later use. Take another 600g of safflower, add water and heat it to about 60°C, soak and extract twice, add water 15 times for the first time, add water 12 times for the second time, extract with dynamic stirring for 0.5-1 hour each time, filter, combine the filtrates, and recover under reduced pressure Concentrate, add the above extract, continue to concentrate until the relative density is about 1.25-1.35, dry under reduced pressure, crush through a 60-mesh sieve, add appropriate amount of auxiliary materials, mix evenly, process according to conventio...

Embodiment 2

[0026] Take 1000g of Coptis chinensis, 400g of Capsicum chinensis, 300g of Sophora japonica, and 500g of myrobalan, crush them, add 500g of safflower, add 60% ethanol to reflux extraction twice, add 12 times the amount for the first time, and add 10 times the amount for the second time, Reflux for 1 to 2 hours each time, filter, combine filtrates, recover ethanol under reduced pressure, concentrate to a thick paste, dry under reduced pressure in microwave ovens, pulverize, add appropriate amount of excipients, mix evenly, process according to conventional methods, compress tablets, and coat have to.

Embodiment 3

[0028] Take 1000g of Huhuanglian, 500g of Tibetan Yinchen, 500g of Sophora japonica, and 500g of Myrobalan, crush them, add 1000g of safflower, add water to decoct and extract twice, add 14 times of water for the first time, and 12 times of water for the second time, and decoct each time After 1-2 hours, filter, combine filtrates, concentrate under reduced pressure, dry, pulverize, add appropriate amount of auxiliary materials, mix well, process according to conventional methods, and pack into capsules.

technical field

[0001] The invention relates to a pharmaceutical composition for treating liver damage, a corresponding medicine and a preparation method thereof. Background technique

[0002] The liver is an important metabolic and secretory organ of the human body. While it is powerful, it is also a fragile organ that can easily cause liver damage. The causes of liver injury mainly include violent liver injury, pathological liver injury, and chemical liver injury. Among them, violent liver injury usually manifests rapidly and is severe, while pathological liver injury and chemical liver injury are the most common. At present, both the overall environment and people's lifestyle are extremely unfavorable to the health of the liver. Factors that cause liver damage exist widely, which is an important reason for the rapid expansion of the number of people with liver damage. If staying up late and working too hard will cause relatively insufficient liver blood flow, affect th...

Examples

Embodiment 1

[0024] Take 600g of Huhuanglian, 450g of Tibetan Yinchen, 150g of Sophora japonica, and 300g of Myrobalan, crush them into coarse powder, add 70% ethanol to reflux and extract twice, add 10 times the amount for the first time, add 8 times the amount for the second time, and add 8 times the amount each time. Flow for 1 to 2 hours, filter, combine the filtrates, recover ethanol under reduced pressure, concentrate, and extract for later use. Take another 600g of safflower, add water and heat it to about 60°C, soak and extract twice, add water 15 times for the first time, add water 12 times for the second time, extract with dynamic stirring for 0.5-1 hour each time, filter, combine the filtrates, and recover under reduced pressure Concentrate, add the above extract, continue to concentrate until the relative density is about 1.25-1.35, dry under reduced pressure, crush through a 60-mesh sieve, add appropriate amount of auxiliary materials, mix evenly, process according to conventio...

Embodiment 2

[0026] Take 1000g of Coptis chinensis, 400g of Capsicum chinensis, 300g of Sophora japonica, and 500g of myrobalan, crush them, add 500g of safflower, add 60% ethanol to reflux extraction twice, add 12 times the amount for the first time, and add 10 times the amount for the second time, Reflux for 1 to 2 hours each time, filter, combine filtrates, recover ethanol under reduced pressure, concentrate to a thick paste, dry under reduced pressure in microwave ovens, pulverize, add appropriate amount of excipients, mix evenly, process according to conventional methods, compress tablets, and coat have to.

Embodiment 3

[0028] Take 1000g of Huhuanglian, 500g of Tibetan Yinchen, 500g of Sophora japonica, and 500g of Myrobalan, crush them, add 1000g of safflower, add water to decoct and extract twice, add 14 times of water for the first time, and 12 times of water for the second time, and decoct each time After 1-2 hours, filter, combine filtrates, concentrate under reduced pressure, dry, pulverize, add appropriate amount of auxiliary materials, mix well, process according to conventional methods, and pack into capsules.