Preparation method of high soluble crystal calcium citrate

Abstract

The invention relates to a preparation method of high soluble crystal calcium citrate in the fields of biochemical engineering, medicine and food. The technical scheme of the method comprises the following steps: (1) mixing citric acid, calcium carbonate and water, serving as raw materials, in a ratio of 3.84:3:1; (2) placing the mixture in a reaction tank at 20-50 DEG C after mixing, starting a machine to perform a chemical reaction for 50-60 minutes; (3) stopping the machine for 25-35 minutes to perform a chemical reaction for maturing; (4) starting the machine for 25-35 minutes to discharge high soluble crystal calcium citrate under the crystallization temperature; and (5) filtering, drying and packaging to obtain the finished product. The invention has the following beneficial effects: the molecular formula of the synthesized high soluble crystal calcium citrate is Ca3H3 (C6H5O7)2(HCO3)3, the solubility is 98%, the high solution type calcium citrate is soluble calcium and can be used to supplement calcium and cure osteoporosis and osteomalacia, human and animals can absorb the high soluble crystal calcium citrate easily; and the calcium citrate injection and calcium citrate oral liquid can also be used, and the use of the high soluble crystal calcium citrate is not limited by insoluble calcium citrate.

Description

technical field [0001] The invention relates to a preparation method of highly soluble crystal calcium citrate in the field of biochemical industry, medicine and food. Background technique [0002] In today's biochemical, pharmaceutical and food markets at home and abroad, the commonly used medicinal ingredients for calcium supplementation, osteoporosis and rickets are mostly calcium citrate tetrahydrate, English name: Calcium citrate tetrahydrate, molecular formula: C12H10Ca3O14 4H 2 O Molecular weight: 570.52, calcium content 21.08%, because it is difficult to dissolve in water, only 0.095g / 100ml dissolved at 25°C, it is not easily absorbed by humans and animals, and its use is limited. Contents of the invention [0003] The object of the present invention is to provide a method for preparing highly soluble crystalline calcium citrate that has high solubility and is easily absorbed by humans and animals. [0004] Technical solution: consists of the following steps: [...

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Problems solved by technology

[0002] In today's biochemical, pharmaceutical and food markets at home and abroad, the commonly used medicinal ingredients for calcium supplementation, osteoporosis and rickets are mostly calcium citrate tetrahydrate. English name: Calcium citrate tetrahydrate, molecular formula: C12H10Ca3O14 4H2O molecular weight: 570.52, calcium content 21.08%, because it is difficult to dissolve in water, only 0.095g / 100ml dissolved at 25 ℃ , people and animals are not easy to absorb, use is restricted

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