Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of high soluble crystal calcium citrate

A technology of calcium citrate and citric acid, which is applied in the field of biochemical medicine and food, and can solve the problems of difficult absorption and restricted use of humans and animals

Inactive Publication Date: 2012-02-15
SHANDONG HENGTONG BIOTECH
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In today's biochemical, pharmaceutical and food markets at home and abroad, the commonly used medicinal ingredients for calcium supplementation, osteoporosis and rickets are mostly calcium citrate tetrahydrate. English name: Calcium citrate tetrahydrate, molecular formula: C12H10Ca3O14 4H2O molecular weight: 570.52, calcium content 21.08%, because it is difficult to dissolve in water, only 0.095g / 100ml dissolved at 25 ℃ , people and animals are not easy to absorb, use is restricted

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of high soluble crystal calcium citrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0013] Will Mix citric acid, calcium carbonate and water according to the ratio of 3.84:3:1; after mixing, put it into a reaction kettle with a temperature of 30 degrees, start the chemical reaction for 55 minutes; stop for 30 minutes, the chemical reaction is mature; start for 30 minutes, Release the highly soluble crystalline calcium citrate at the crystallization temperature; filter, dry and pack the finished product.

[0014] Its chemical reaction formula: 3CaCO 3 +2C 6 h 8 o 7 → Ca 3 h 3 (C 6 h 5 o 7 ) 2 (HCO 3 ) 3

[0015] Combined with national standards and enterprise standards, the test results of the company's testing department are:

[0016]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of high soluble crystal calcium citrate in the fields of biochemical engineering, medicine and food. The technical scheme of the method comprises the following steps: (1) mixing citric acid, calcium carbonate and water, serving as raw materials, in a ratio of 3.84:3:1; (2) placing the mixture in a reaction tank at 20-50 DEG C after mixing, starting a machine to perform a chemical reaction for 50-60 minutes; (3) stopping the machine for 25-35 minutes to perform a chemical reaction for maturing; (4) starting the machine for 25-35 minutes to discharge high soluble crystal calcium citrate under the crystallization temperature; and (5) filtering, drying and packaging to obtain the finished product. The invention has the following beneficial effects: the molecular formula of the synthesized high soluble crystal calcium citrate is Ca3H3 (C6H5O7)2(HCO3)3, the solubility is 98%, the high solution type calcium citrate is soluble calcium and can be used to supplement calcium and cure osteoporosis and osteomalacia, human and animals can absorb the high soluble crystal calcium citrate easily; and the calcium citrate injection and calcium citrate oral liquid can also be used, and the use of the high soluble crystal calcium citrate is not limited by insoluble calcium citrate.

Description

technical field [0001] The invention relates to a preparation method of highly soluble crystal calcium citrate in the field of biochemical industry, medicine and food. Background technique [0002] In today's biochemical, pharmaceutical and food markets at home and abroad, the commonly used medicinal ingredients for calcium supplementation, osteoporosis and rickets are mostly calcium citrate tetrahydrate, English name: Calcium citrate tetrahydrate, molecular formula: C12H10Ca3O14 4H 2 O Molecular weight: 570.52, calcium content 21.08%, because it is difficult to dissolve in water, only 0.095g / 100ml dissolved at 25°C, it is not easily absorbed by humans and animals, and its use is limited. Contents of the invention [0003] The object of the present invention is to provide a method for preparing highly soluble crystalline calcium citrate that has high solubility and is easily absorbed by humans and animals. [0004] Technical solution: consists of the following steps: [...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/265C07C51/41
Inventor 王元达
Owner SHANDONG HENGTONG BIOTECH