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Method for synthesizing anticancer compound Na4Bi2Mn2W20C6H84N4O105

A na4bi2mn2w20c6h84n4o105, synthetic method technology, applied in the field of synthesis of anticancer compounds, to achieve good inhibition rate, strong proliferation inhibition effect

Inactive Publication Date: 2013-09-18
HARBIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These studies only include inhibition of proliferation, observation of cell morphology, detection of cell cycle, etc.

Method used

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  • Method for synthesizing anticancer compound Na4Bi2Mn2W20C6H84N4O105
  • Method for synthesizing anticancer compound Na4Bi2Mn2W20C6H84N4O105
  • Method for synthesizing anticancer compound Na4Bi2Mn2W20C6H84N4O105

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specific Embodiment approach 1

[0008] Embodiment 1: The anticancer compound Na of this embodiment 4 Bi 2 Mn 2 W 20 C 6 H 84 N 4 O 105 The synthesis method of the compound is realized according to the following steps: 1. Under magnetic stirring, 4-5 mmol of Na 2 WO 4 Dissolve in 80~120ml deionized water, heat to 80~120℃, then add 6mol / L HCl dropwise to adjust pH to 5.0~7.0 to obtain solution A; 2. Put 0.5~1mmol MnCl 2 , 0.8-1.2 mmol of solid imidazole and 0.3-0.8 mmol of Bi(NO) dissolved in 6 mol / L HCl 3 ) 3 At the same time, it was added to solution A, mixed and heated to 80-120 °C for 1-2 hours, then cooled to room temperature, filtered and left to stand for 5-10 days to complete the anticancer compound Na. 4 Bi 2 Mn 2 W 20 C 6 H 84 N 4 O 105 The synthesis of ; wherein the consumption of HCl in step 2 is 10mL.

[0009] The anticancer compound Na obtained in this embodiment 4 Bi 2 Mn 2 W 20 C 6 H 84 N 4 O 105 For the yellow bulk crystals.

[0010] The cooling in step 2 of this emb...

specific Embodiment approach 2

[0011] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in step 1, 4 mmol of Na 2 WO 4 Dissolve in 80 ml of deionized water and heat to 80°C. Other steps and parameters are the same as in the first embodiment.

specific Embodiment approach 3

[0012] Embodiment 3: The difference between this embodiment and Embodiment 1 is that in step 1, 5 mmol of Na 2 WO 4 Dissolve in 120 ml of deionized water and heat to 120°C. Other steps and parameters are the same as in the first embodiment.

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Abstract

The invention provides a method for synthesizing an anticancer compound Na4Bi2Mn2W20C6H84N4O105, which relates to a method for synthesizing an anticancer compound. The method comprises the following steps: 1, dissolving Na2WO4 under magnetic stirring in deionized water and heating, then regulating pH to obtain a solution A; 2, simultaneously adding MnCl2, solid imidazole and Bi(NO3)3 dissolved in HCl, uniformly mixing and heating to react, then cooling to the room temperature, filtering and standing. The synthesized Na4Bi2Mn2W20C6H84N4O105 is a polyoxometallate modified by active imidazole, has strong inhibition effect on tumor cells of human stomach, and has good inhibition rate on tumor cells of liver cancer and colorectal carcinoma.

Description

technical field [0001] The present invention relates to a method for synthesizing anticancer compounds. Background technique [0002] At present, the biological activities of polyoxometalates at home and abroad are mostly concentrated on antiviral research, and there are few reports on anticancer research. In 1973, Jasmin et al. [NH 4 ] 17 Na[NaSb 9 W 21 O 86 ]14H 2 O(HPA-23) inhibition of virus-induced tumors was studied. In 1980, Jozsef et al. first used homopolyoxometalates (NH 4 ) 6 [Mo 7 O 24 ]·6H 2 O; In 1988, Yamase et al. found (NH 3 Pri) 6 [Mo 7 O 24 ]·3H 2 O(PM-8) has antitumor activity; in 1992, Na[IMo 7 O 24 ] As an anti-colon cancer drug in Japan, in 2004, Wang Enbo's research group reported the in vitro anti-tumor activity of heteropolytungstate and organic amine modified polyvanadate. These studies only include inhibition of proliferation, observation of cell morphology, detection of cell cycle, etc. Therefore, the development of polyoxometal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F19/00A61K31/555A61P35/00
Inventor 周百斌王璐王春晓初丽丽吴江苏占华于凯
Owner HARBIN NORMAL UNIVERSITY