Method for synthesizing anticancer compound Na4Bi2Mn2W20C6H84N4O105

A technology of na4bi2mn2w20c6h84n4o105 and a synthesis method is applied in the field of synthesis of anticancer compounds to achieve the effect of strong proliferation inhibition and good inhibition rate

Inactive Publication Date: 2012-02-15
HARBIN NORMAL UNIVERSITY
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

These studies only include inhibition of proliferation, observation of cell morphology, detection of cell cycle, etc.

Method used

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  • Method for synthesizing anticancer compound Na4Bi2Mn2W20C6H84N4O105
  • Method for synthesizing anticancer compound Na4Bi2Mn2W20C6H84N4O105
  • Method for synthesizing anticancer compound Na4Bi2Mn2W20C6H84N4O105

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specific Embodiment approach 1

[0008] Specific embodiment one: the anticancer compound Na of this embodiment 4 Bi 2 mn 2 W 20 C 6 h 84 N 4 o 105 The synthetic method of is realized according to the following steps: one, under magnetic stirring, the Na of 4~5mmol 2 WO 4 Dissolve in 80-120ml of deionized water, and heat to 80-120°C, then add 6mol / L HCl dropwise to adjust the pH to 5.0-7.0 to obtain solution A; 2. Mix 0.5-1mmol of MnCl 2 , 0.8-1.2 mmol of solid imidazole and 0.3-0.8 mmol of Bi(NO) dissolved in 6 mol / L HCl 3 ) 3 At the same time, add it to solution A, mix it and heat it to 80-120°C for 1-2 hours, then cool it to room temperature, filter it and let it rest for 5-10 days to complete the anticancer compound Na 4 Bi 2 mn 2 W 20 C 6 h 84 N 4 o 105 Synthesis; wherein the amount of HCl in step 2 is 10mL.

[0009] The obtained anticancer compound Na in the present embodiment 4 Bi 2 mn 2 W 20 C 6 h 84 N 4 o 105 It is yellow blocky crystal.

[0010] The cooling in the second st...

specific Embodiment approach 2

[0011] Specific implementation mode 2: The difference between this implementation mode and specific implementation mode 1 is that in step 1, 4~? mmol Na 2 WO 4 Dissolve in 80ml of deionized water and heat to 80°C. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0012] Specific embodiment three: the difference between this embodiment and specific embodiment one is that in step one, 5 mmol of Na 2 WO 4 Dissolve in 120ml of deionized water and heat to 120°C. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The invention provides a method for synthesizing an anticancer compound Na4Bi2Mn2W20C6H84N4O105, which relates to a method for synthesizing an anticancer compound. The method comprises the following steps: 1, dissolving Na2WO4 under magnetic stirring in deionized water and heating, then regulating pH to obtain a solution A; 2, simultaneously adding MnCl2, solid imidazole and Bi(NO3)3 dissolved inHCl, uniformly mixing and heating to react, then cooling to the room temperature, filtering and standing. The synthesized Na4Bi2Mn2W20C6H84N4O105 is a polyoxometallate modified by active imidazole, has strong inhibition effect on tumor cells of human stomach, and has good inhibition rate on tumor cells of liver cancer and colorectal carcinoma.

Description

technical field [0001] The invention relates to a synthesis method of an anticancer compound. Background technique [0002] At present, domestic and foreign studies on the biological activity of polyoxometalates are mostly focused on antiviral research, and there are few reports on anticancer research. In 1973, Jasmin et al. [NH 4 ] 17 Na[NaSb 9 W 21 o 86 ]14H 2 O(HPA-23) has been studied to inhibit tumors induced by viruses. In 1980, Jozsef et al. first used isopolyoxometalates (NH 4 ) 6 [Mo 7 o 24 ]·6H 2 O; In 1988, Yamase et al found (NH 3 Pri) 6 [Mo 7 o 24 ]·3H 2 O(PM-8) has antitumor activity; In 1992, Na[IMo 7 o 24 ] As an anti-colon cancer drug, it was used clinically in Japan. In 2004, Wang Enbo's research group reported the in vitro anti-tumor activity of heteropolytungstate and organic amine-modified polyvanadate. These studies only included inhibition of proliferation, observation of cell morphology, detection of cell cycle, etc. Therefore, the d...

Claims

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Application Information

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IPC IPC(8): C07F19/00A61K31/555A61P35/00
Inventor 周百斌王璐王春晓初丽丽吴江苏占华于凯
Owner HARBIN NORMAL UNIVERSITY
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