A kind of sweet potato extract and its preparation method and application

A technology of extract and sweet potato, applied in the field of sweet potato extract and its preparation, to achieve high commercial application development value, low production cost, and strong proliferation inhibitory effect

Active Publication Date: 2019-05-21
INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the anticancer active substances of sweet potato has not been reported yet.

Method used

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  • A kind of sweet potato extract and its preparation method and application
  • A kind of sweet potato extract and its preparation method and application
  • A kind of sweet potato extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1: the preparation of sweet potato powder

[0060] Wash, drain, and slice 1000g of fresh sweet potatoes, put them in a tray and pre-freeze them in a refrigerator at -40°C for 24 hours, then take them out and put them in a vacuum freeze dryer, and dry them at -66°C for 48 hours at a vacuum of 50Pa Finally, adopt universal pulverizer to pulverize, make the sweet potato flour of 80-100 purpose.

Embodiment 2

[0061] Embodiment 2: the preparation of sweet potato powder

[0062] Wash, drain, and slice 1500g fresh sweet potatoes, put them in a tray and pre-freeze them in a refrigerator at -20°C for 36 hours, take them out and put them in a vacuum freeze dryer, and dry them at -70°C for 48 hours at a vacuum of 100Pa , using a universal pulverizer to pulverize to obtain 80-100 mesh sweet potato flour.

Embodiment 3

[0063] Embodiment 3: the preparation of sweet potato crude extract

[0064] Get 100 g of sweet potato powder obtained in Example 1, add 3 times the volume (300 mL) of chloroform and methanol mixture (2:1, v / v), extract at -4 ° C for 24 hours, filter after extraction, and collect Add 3 times the volume (300mL) of the mixture of chloroform and methanol to the supernatant and residue, extract at -4°C for 2 hours, repeat the extraction twice, combine the supernatants, and store them at a temperature of 35°C and a vacuum of Under the condition of 0.09MPa, the organic reagent (chloroform and methanol) was removed by rotary evaporation at 70rpm to obtain 2g crude sweet potato extract.

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Abstract

The invention discloses sweet potato extract and a preparation method and application thereof. The preparation method includes: 1), cleaning, draining, slicing, drying and then smashing sweet potato to obtain sweet potato powder; 2), taking a mixed solution of chloroform and methanol as extractant to leach the sweet potato powder to obtain crude sweet potato extract; 3), dissolving the crude sweet potato extract in the mixed solution of chloroform and methanol, taking chloroform and acetone as eluent to perform solid-phase extraction separation on obtained crude sweet potato extract solution, and collecting acetone elution components; 4), using a chromatographic column taking macroporous adsorption resin as adsorbent to perform adsorption chromatography on the acetone elution components, sequentially adopting water and alcohol solutions of 20-40% and 50-60% in volume percentage for elution, and collecting elution components of the alcohol solution of 50-60% in volume percentage to obtain the sweet potato extract. Pharmacodynamic experiments show that the sweet potato extract has high proliferation inhibiting ability to colon cancer cells and breast cancer cells.

Description

technical field [0001] The invention relates to a sweet potato extract and its preparation method and application. Background technique [0002] At present, cancer is one of the main diseases that cause human death. According to the latest data released by the World Health Organization, the global cancer incidence is expected to rise sharply from 14 million in 2012 to 22 million in 2032. During the same period, the number of cancer deaths will rise from 8.2 million per year to 13 million per year. In 2012, the incidence of cancer in my country accounted for almost half of the world, ranking first. Traditional cancer treatments such as radiotherapy and chemotherapy are effective in killing cancer cells to a certain extent, but they can also damage and destroy normal cells. Compared with traditional cancer treatments, the advantages of natural anticancer active ingredients are high activity and no or low adverse reactions. [0003] Sweet potato (Ipomoea batatas) is an impor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/39A61P35/00
Inventor 木泰华赵仕婷张苗孙红男陈井旺
Owner INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
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