Method for predicating novel curative effects of medicament based on biological process and application of method
A biological process and drug technology, which is applied in the discovery of new drug efficacy and the field of drug efficacy, can solve problems such as inapplicable diseases, weak quantitative ranking, and inability to make strong correlations between drugs and therapeutic functions.
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[0061] example 1:
[0062] Etanercept (trade name Enbrel) is a recombinant protein drug that combines TNF developed by Amgenc and Pfizer in the United States. Its approved indication is rheumatoid arthritis. The DrugBank database contains 14 targets for its action.
[0063] Construct a biological process data set; use the pathway information in KEGG as the biological process data set, a total of 183 biological processes.
[0064] Construct a data set of disease and disease-related proteins; (CTD (http: / / ctd.mdibl.org / ) the disease and disease-related proteins marked as "curated" in the database, and the DDPA database (http: / / lifecenter.sgst.cn / ddpa / ), including a total of 1101 diseases and 5898 disease-related proteins).
[0065] Construction of the biological process spectrum of diseases
[0066] Based on the collected disease and disease-related protein data, the Fisher’s exact test statistical model was used to calculate the degree of influence of the 183 biological processes coll...
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[0088] Example 2:
[0089] Aripiprazole (trade name Abilify) is a third-generation atypical antipsychotic approved by the US FDA on November 15, 2002. It is a Dopamine receptor D2 activator of quinolinone derivatives. Used to treat schizophrenia. A total of 25 targets are included in the DrugBank database.
[0090] Construct a biological process data set; use the pathway information except disease types in KEGG (http: / / www.genome.jp / kegg / ) as the biological process data set, a total of 183 biological processes.
[0091] Construct a data set of disease and disease-related proteins; (CTD (http: / / ctd.mdibl.org / ) the disease and disease-related proteins marked as "curated" in the database, and the DDPA database (http: / / lifecenter.sgst.cn / ddpa / ), including a total of 1101 diseases and 5898 disease-related proteins).
[0092] Construction of the biological process spectrum of diseases
[0093] Based on the collected disease and disease-related protein data, the Fisher’s exact test statist...
Example
[0111] Example 3:
[0112] Herceptin (Trastuzumab, trade name Herceptin) is a breast cancer monoclonal antibody drug that is positive for HER-2 developed by Roche Pharmaceuticals. The main therapeutic target HER-2 and 12 targets with unknown functions are collected in the DrugBank database.
[0113] Construct a biological process data set; use the pathway information except disease types in KEGG (http: / / www.genome.jp / kegg / ) as the biological process data set, a total of 183 biological processes.
[0114] Construct a data set of disease and disease-related proteins; (CTD (http: / / ctd.mdibl.org / ) the disease and disease-related proteins marked as "curated" in the database, and the DDPA database (http: / / lifecenter.sgst.cn / ddpa / ), including a total of 1101 diseases and 5898 disease-related proteins).
[0115] Construction of the biological process spectrum of diseases
[0116] Based on the collected disease and disease-related protein data, the Fisher’s exact test statistical model was us...
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